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Cited by 328Neuroendocrine regulation and behaviorNeuropeptides and Animal PhysiologyCardiovascular, Neuropeptides, and Oxidative Stress Research

The DOI matches its Crossref record.

Central Nervous System Effects of the Neurohypophyseal Hormones and Related Peptides

de Wied, David, Diamant, Michaela, Fodor, Mariann·1993·Frontiers in Neuroendocrinology
DOI 10.1006/frne.1993.1009
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Abstract

This review of the CNS effects of the neurohypophyseal hormones and related neuropeptides discusses recent data illustrating the significance of these principles in brain function, synthesis, distribution, in particular in extrahypothalamic brain structures, binding sites, and signal transduction. Binding sites for vasopressin of the vascular V1a type have been found in the CNS and there is evidence for the existence of a subtype of the antidiuretic V2 receptor in the brain. Also two types of oxytocin binding sites have been detected. One widely distributed throughout the CNS is comparable to the uterine type receptor and a sexually dimorphic slightly different type is found in the ventromedial nucleus. Vasopressin and oxytocin can be converted to highly selective C-terminal fragments as AVP-(4-9) and OXT-(4-9) and shorter fragments. Conversely they can be acetylated. This almost completely blocks intrinsic activity in bioassays for central and peripheral effects. Such modifications are a good example of the plasticity of a neuropeptide system. For a number of CNS effects of the neurohypophyseal hormones, the whole molecule is required, as it is for their endocrine effects. This is the case for the influence of vasopressin on social communication, temperature regulation, epilepsy, and barrel rotation which may be an animal model of febrile convulsions, and some aspects of the central regulation of the cardiovascular system and for oxytocin on sexual behavior, social communica…

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Metadata

Authors
de Wied, D., Diamant, M., & Fodor, M.
Affiliations
Utrecht University (NL)
ORCID
Fodor, Mariann
Venue
Frontiers in Neuroendocrinology
Publisher
Elsevier BV
Published
1993-10
Volume
14
Issue
4
Pages
251-302
ISSN
0091-3022 (ISSN-L)
DOI
10.1006/frne.1993.1009
OpenAlex
W1972977442
Cited by
327
References
0
Citations by year
2026: 4 · 2025: 6 · 2024: 6 · 2023: 2 · 2022: 7 · 2021: 6 · 2020: 7 · 2019: 6 · 2018: 9 · 2017: 8 · 2016: 6 · 2015: 6 · 2014: 14 · 2013: 9 · 2012: 17
FWCI
17.77
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Frontiers in Neuroendocrinology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
  • Health Sciences › Medicine › Surgery › Cardiovascular, Neuropeptides, and Oxidative Stress Research
Keywords
neurohypophyseal hormones, vasopressin, oxytocin, neuropeptides, vasopressin V1a receptor, V2 receptor, oxytocin receptor, C-terminal fragment, signal transduction, social communication, temperature regulation, epilepsy, febrile seizures, cardiovascular regulation, sexual behavior, social recognition, learning and memory, neurotransmitters, norepinephrine, dopamine, serotonin, glutamate
MeSH terms
Amino Acid Sequence, Animals, Arginine Vasopressin, Brain, Cardiovascular Physiological Phenomena, Central Nervous System, Epilepsy, Feeding Behavior, Female, Humans, Maternal Behavior, Molecular Sequence Data, Neurons, Neuropeptides, Oxytocin, Pituitary Hormones, Posterior, Social Behavior, Vasopressins, Receptors, Vasopressin

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