Cited by 328Neuroendocrine regulation and behaviorNeuropeptides and Animal PhysiologyCardiovascular, Neuropeptides, and Oxidative Stress Research

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Central Nervous System Effects of the Neurohypophyseal Hormones and Related Peptides

de Wied, David, Diamant, Michaela, Fodor, Mariann·1993·Frontiers in Neuroendocrinology

DOI 10.1006/frne.1993.1009

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Abstract

This review of the CNS effects of the neurohypophyseal hormones and related neuropeptides discusses recent data illustrating the significance of these principles in brain function, synthesis, distribution, in particular in extrahypothalamic brain structures, binding sites, and signal transduction. Binding sites for vasopressin of the vascular V1a type have been found in the CNS and there is evidence for the existence of a subtype of the antidiuretic V2 receptor in the brain. Also two types of oxytocin binding sites have been detected. One widely distributed throughout the CNS is comparable to the uterine type receptor and a sexually dimorphic slightly different type is found in the ventromedial nucleus. Vasopressin and oxytocin can be converted to highly selective C-terminal fragments as AVP-(4-9) and OXT-(4-9) and shorter fragments. Conversely they can be acetylated. This almost completely blocks intrinsic activity in bioassays for central and peripheral effects. Such modifications are a good example of the plasticity of a neuropeptide system. For a number of CNS effects of the neurohypophyseal hormones, the whole molecule is required, as it is for their endocrine effects. This is the case for the influence of vasopressin on social communication, temperature regulation, epilepsy, and barrel rotation which may be an animal model of febrile convulsions, and some aspects of the central regulation of the cardiovascular system and for oxytocin on sexual behavior, social communica…

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Authors: de Wied, D., Diamant, M., & Fodor, M.
Affiliations: Utrecht University (NL)
ORCID: Fodor, Mariann
Venue: Frontiers in Neuroendocrinology
Publisher: Elsevier BV
Published: 1993-10
Volume: 14
Issue: 4
Pages: 251-302
ISSN: 0091-3022 (ISSN-L)
DOI: 10.1006/frne.1993.1009
OpenAlex: W1972977442
Cited by: 327
References: 0
Citations by year: 2026: 4 · 2025: 6 · 2024: 6 · 2023: 2 · 2022: 7 · 2021: 6 · 2020: 7 · 2019: 6 · 2018: 9 · 2017: 8 · 2016: 6 · 2015: 6 · 2014: 14 · 2013: 9 · 2012: 17
FWCI: 17.77
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Frontiers in Neuroendocrinology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Health Sciences › Medicine › Surgery › Cardiovascular, Neuropeptides, and Oxidative Stress Research
Keywords: neurohypophyseal hormones, vasopressin, oxytocin, neuropeptides, vasopressin V1a receptor, V2 receptor, oxytocin receptor, C-terminal fragment, signal transduction, social communication, temperature regulation, epilepsy, febrile seizures, cardiovascular regulation, sexual behavior, social recognition, learning and memory, neurotransmitters, norepinephrine, dopamine, serotonin, glutamate
MeSH terms: Amino Acid Sequence, Animals, Arginine Vasopressin, Brain, Cardiovascular Physiological Phenomena, Central Nervous System, Epilepsy, Feeding Behavior, Female, Humans, Maternal Behavior, Molecular Sequence Data, Neurons, Neuropeptides, Oxytocin, Pituitary Hormones, Posterior, Social Behavior, Vasopressins, Receptors, Vasopressin

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Central Nervous System Effects of the Neurohypophyseal Hormones and Related Peptides

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