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Genomic Structure and Assignment of theRhoH/TTFSmall GTPase Gene (ARHH) to 4p13 byin SituHybridization
Abstract
The RhoH/TTF (ARHH) gene encodes a new member of the Ras superfamily of small GTPases. The gene was identified by fusion to the BCL6/LAZ3 oncogene in an initially described t(3;4)(q27;p11) translocation in a non-Hodgkin's lymphoma cell line. The predicted amino acid sequence of the RhoH/TTF gene product includes Rho-like GTPase structural motifs. The RhoH/TTF gene is restrictively expressed in hematopoietic cells and tissues. Mutations in the human RAS genes have been shown previously to be tumorigenic; in the search for a potential implication of the RhoH/TTF gene in hemopoietic malignancies, we established its genomic structure. The RhoH/TTF gene spans 35 kb and contains two exons, with the second bearing the entire amino-acid-coding region. Chromosomal mapping, by FISH experiments, places the RhoH/TTF gene on the short arm of chromosome 4, band p13.
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In the citing paper
“RhoH is a hematopoietic-specific, GTPase-deficient member of the Rho GTPase family that was first identified as a hypermutable gene in human B lineage lymphomas.”
From A Unique Carboxyl-terminal Insert Domain in the Hematopoietic-specific, GTPase-deficient Rho GTPase RhoH Regulates Post-translational Processing (2013) · cites this paper as [4]
In the citing paper
“RhoH remains in a constitutively active state and thus its effects are regulated by expression levels or post-translational modifications.”
From A Unique Carboxyl-terminal Insert Domain in the Hematopoietic-specific, GTPase-deficient Rho GTPase RhoH Regulates Post-translational Processing (2013) · cites this paper as [4]
In the citing paper
“RhoH was initially defined as a fusion partner and subject to somatic hypermutation in B cell lymphomas, although the biological relevance of RhoH mutations, which are mainly found in non-coding regions in these diseases, has never been defined (4 -6, 14, 15, 52).”
From A Unique Carboxyl-terminal Insert Domain in the Hematopoietic-specific, GTPase-deficient Rho GTPase RhoH Regulates Post-translational Processing (2013) · cites this paper as [4]
In the citing paper
“RhoH, a hematopoietic-specific member of the RhoE/Rnd3 subfamily of GTPases was initially identified as hypermutable gene and translocation partner in human B-cell lymphomas suggesting its involvement in the pathogenesis of B-cell malignancies.12–15”
From RhoH is critical for cell-microenvironment interactions in chronic lymphocytic leukemia in mice and humans (2012) · cites this paper as [12]
In the citing paper
“RhoH has no intrinsic GTPase activity and remains in a GTP-bound and constitutively active state. Therefore it is regulated by expression levels and posttranslational modifications.12”
From RhoH is critical for cell-microenvironment interactions in chronic lymphocytic leukemia in mice and humans (2012) · cites this paper as [12]
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Research works printed but not linked: 15
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Cited by
Li, X., Bu, X., Lu, B., Avraham, H., Flavell, R. A., & Lim, B. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.4.1158-1171.2002 · Cited by 153
Gu, Y., Jasti, A. C., Jansen, M., & Siefring, J. E. (2005) · Blood · doi:10.1182/blood-2004-04-1604 · Cited by 106
Hematopoietic-specific Rho GTPases Rac2 and RhoH and human blood disorders
Troeger, A., & Williams, D. A. (2013) · Experimental Cell Research · doi:10.1016/j.yexcr.2013.07.002 · Cited by 73
Troeger, A., Johnson, A. J., Wood, J., Blum, W. G., Andritsos, L. A., Byrd, J. C., & Williams, D. A. (2012) · Blood · doi:10.1182/blood-2011-12-395939 · Cited by 55
The small GTPase RhoH is an atypical regulator of haematopoietic cells
Fueller, F., & Kubatzky, K. F. (2008) · Cell Communication and Signaling · doi:10.1186/1478-811x-6-6 · Cited by 40
Underexpression of RhoH in Hairy Cell Leukemia
Galiègue-Zouitina, S., Delestré, L., Dupont, C., Troussard, X., & Shelley, C. S. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-5661 · Cited by 34
RhoH GTPase: A Key Regulator of Hematopoietic Cell Proliferation and Apoptosis?
Gu, Y., Zheng, Y., & Williams, D. A. (2005) · Cell Cycle · doi:10.4161/cc.4.2.1395 · Cited by 20
Troeger, A., Chae, H.-D., Senturk, M., Wood, J., & Williams, D. A. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.505727 · Cited by 15
Metadata
- Authors
- Dallery-Prudhomme, E., Roumier, C., Denis, C., Preudhomme, C., Kerckaert, J.-P., & Galiegue-Zouitina, S.
- Venue
- Genomics
- Publisher
- Elsevier BV
- Published
- 1997-07
- Volume
- 43
- Issue
- 1
- Pages
- 89-94
- ISSN
- 0888-7543
- Cited by
- 39
- References
- 0
- Language
- en
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