The DOI matches its Crossref record; 35 of the 36 references it cites were found in a registry or an index.
Characterization of MAD2B and Other Mitotic Spindle Checkpoint Genes
Open accessAbstract
Aneuploidy is a characteristic of the majority of human cancers, and recent work has suggested that mitotic checkpoint defects play a role in its development. To further explore this issue, we isolated a novel human gene, MAD2B (MAD2L2), which is homologous to the spindle checkpoint gene MAD2 (MAD2L1). We determined the chromosomal localization of it and other spindle checkpoint genes, including MAD1L1, MAD2, BUB3, TTK (MPS1L1), and CDC20. In addition, we resolved the genomic intron-exon structure of the human BUB1 gene. We then searched for mutations in these genes in a panel of 19 aneuploid colorectal tumors. No new mutations were identified, suggesting that genes yet to be discovered are responsible for most of the checkpoint defects observed in aneuploid cancers.
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“Hence, our results provide one explanation for why loss-of-function mutations in spindle checkpoint genes are uncommon in human cancers 11,12 .”
From Rb inactivation promotes genomic instability by uncoupling cell cycle progression from mitotic control (2004) · cites this paper as [11]
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“loss-of-function mutations in spindle checkpoint genes are rarely observed in human tumours 11,12 .”
From Rb inactivation promotes genomic instability by uncoupling cell cycle progression from mitotic control (2004) · cites this paper as [11]
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Lengauer, C., Kinzler, K. W., & Vogelstein, B. (1998) · Nature · doi:10.1038/25292 · Cited by 4,168
Self-citationGenetic instability in colorectal cancers
Lengauer, C., Kinzler, K. W., & Vogelstein, B. (1997) · Nature · doi:10.1038/386623a0 · Cited by 1,995
Self-citationMutations of mitotic checkpoint genes in human cancers
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Zur Frage der Entstehung maligner Tumoren
Boveri, T. (1914) · Cited by 801
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Chen, R., Waters, J. C., Salmon, E. D., & Murray, A. W. (1996) · Science · doi:10.1126/science.274.5285.242 · Cited by 783
Defects in a cell cycle checkpoint may be responsible for the genomic instability of cancer cells
Hartwell, L. H. (1992) · Cell · doi:10.1016/0092-8674(92)90586-2 · Cited by 770
Identification of a Human Mitotic Checkpoint Gene: hsMAD2
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The use of microarray data integration to improve cancer prognosis
Zhang, Z. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/69df-7r22
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Schomburg, D., Schomburg, I., & Chang, A. (2009) · Springer eBooks · doi:10.1007/978-3-540-85699-3_1
Asghar, A., & Elowe, S. (2016) · Springer eBooks · doi:10.1007/978-1-4614-6438-9_101546-1
Asghar, A., & Elowe, S. (2017) · Springer eBooks · doi:10.1007/978-3-319-67199-4_101546
Chu, M. L.-H., & Eyers, P. A. (2010) · AfCS-Nature Molecule Pages · doi:10.1038/mp.a000882.01
Genomic Instability, DNA Repair Pathways, and Cancer
Capellá, G., & Peinado, M. A. (2004) · Humana Press eBooks · doi:10.1007/978-1-59259-664-5_15
Significance of REV7 Expression in p16‐Negative Oropharyngeal Squamous Cell Carcinoma
Momiyama, K., Tsutsumi, S., Sakurai, Y., Mogi, S., Miyamoto, S., Murakumo, Y., & Yamashita, T. (2024) · Head & Neck · doi:10.1002/hed.28015
Influence of centrosome amplification on the response to chemotherapy in epithelial ovarian cancer
Fantozzi, G. (2023) · theses.fr (ABES) · doi:10.70675/9023fab1z003az407bz9b02z2054939e787d
DNA Polymerase Gamma Mutations in Male Infertility and Ageing
Rovio, A. T. (2006) · Tampere University Institutional Repository (Tampere University)
Metadata
- Authors
- Cahill, D. P., da Costa, L. T., Carson-Walter, E. B., Kinzler, K. W., Vogelstein, B., & Lengauer, C.
- Affiliations
- Johns Hopkins University (US)
- Howard Hughes Medical Institute (US)
- Venue
- Genomics
- Publisher
- Elsevier BV
- Published
- 1999-06
- Volume
- 58
- Issue
- 2
- Pages
- 181-187
- ISSN
- 0888-7543 (ISSN-L)
- OpenAlex
- W1970916591
- Cited by
- 212
- References
- 36
- Citations by year
- 2025: 2 · 2024: 2 · 2023: 7 · 2021: 4 · 2020: 3 · 2019: 4 · 2018: 5 · 2017: 4 · 2016: 5 · 2015: 11 · 2014: 1 · 2013: 6 · 2012: 6
- FWCI
- 7.21
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Genomics (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (CA62924, CA43460)
- National Cancer Institute (CA43460, P50CA062924, CA 62924)
- National Institute of General Medical Sciences (T32GM007184, GM07184)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Keywords
- MAD2L2, mitotic spindle checkpoint, aneuploidy, colorectal cancer, chromosomal localization, gene structure, BUB1, Bub3, TTK, CDC20, MAD1L1, Mad2
- MeSH terms
- Amino Acid Sequence, Colonic Neoplasms, DNA Mutational Analysis, Exons, Humans, Introns, Spindle Apparatus, Molecular Sequence Data, Polymorphism, Genetic, Proteins, Tumor Cells, Cultured, Databases, Factual, Sequence Homology, Amino Acid, DNA Primers, Physical Chromosome Mapping, Mad2 Proteins
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