The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
The hemochromatosis protein HFE competes with transferrin for binding to the transferrin receptor 1 1Edited by I. A. Wilson
Abstract
HFE is a class I major histocompatibility complex (MHC)-related protein that is mutated in patients with the iron overload disease hereditary hemochromatosis. HFE binds to transferrin receptor (TfR), the receptor used by cells to obtain iron in the form of diferric transferrin (Fe-Tf). Previous studies demonstrated that HFE and Fe-Tf can bind simultaneously to TfR to form a ternary complex, and that membrane-bound or soluble HFE binding to cell surface TfR results in a reduction in the affinity of TfR for Fe-Tf. We studied the inhibition by soluble HFE of the interaction between soluble TfR and Fe-Tf using radioactivity-based and biosensor-based assays. The results demonstrate that HFE inhibits the TfR:Fe-Tf interaction by binding at or near the Fe-Tf binding site on TfR, and that the Fe-Tf:TfR:HFE ternary complex consists of one Fe-Tf and one HFE bound to a TfR homodimer.
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“mitochondrial ferritin genes do not have IRE in both the human and the mouse (74, 182).”
From Intracellular iron transport and storage: from molecular mechanisms to health implications (2008) · cites this paper as [182]
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Research works printed but not linked: 1
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Metadata
- Authors
- Lebrón, J. A., West, A. P., & Bjorkman, P. J.
- Affiliations
- California Institute of Technology (US)
- Venue
- Journal of Molecular Biology
- Publisher
- Elsevier BV
- Published
- 1999-11
- Volume
- 294
- Issue
- 1
- Pages
- 239-245
- ISSN
- 0022-2836 (ISSN-L)
- OpenAlex
- W2061390170
- Cited by
- 182
- References
- 22
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 1 · 2022: 3 · 2021: 2 · 2020: 3 · 2018: 2 · 2017: 4 · 2016: 5 · 2015: 2 · 2014: 4 · 2013: 10 · 2012: 5
- Type
- book review
- Language
- en
- Open access
- closed
- Locations
- Journal of Molecular Biology (publishedVersion)
- PubMed (publishedVersion)
- CaltechAUTHORS (California Institute of Technology) (submittedVersion)
- Funders
- National Institute of General Medical Sciences (T32GM007616, GM07616)
- Topics
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Hemoglobin structure and function
- Keywords
- HFE gene, transferrin receptor 1, hereditary hemochromatosis, iron overload, transferrin, ternary complex, ligand-receptor interactions, iron absorption
- MeSH terms
- Hemochromatosis Protein, Binding, Competitive, Ferric Compounds, Hemochromatosis, HLA Antigens, Humans, Membrane Proteins, Protein Binding, Receptors, Transferrin, Recombinant Proteins, Transferrin, Biosensing Techniques, Histocompatibility Antigens Class I
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