Cited by 296Abdominal vascular conditions and treatmentsBlood properties and coagulationGastrointestinal motility and disorders

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Regulation of Intestinal Blood Flow

Matheson, Paul J., Wilson, Mark A., Garrison, R.Neal·2000·Journal of Surgical Research

DOI 10.1006/jsre.2000.5862

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Abstract

The gastrointestinal system anatomically is positioned to perform two distinct functions: to digest and absorb ingested nutrients and to sustain barrier function to prevent transepithelial migration of bacteria and antigens. Alterations in these basic functions contribute to a variety of clinical scenarios. These primary functions intrinsically require splanchnic blood flow at both the macrovascular and microvascular levels of perfusion. Therefore, a greater understanding of the mechanisms that regulate intestinal vascular perfusion in the normal state and during pathophysiological conditions would be beneficial. The purpose of this review is to summarize the current understanding regarding the regulatory mechanisms of intestinal blood flow in fasted and fed conditions and during pathological stress.

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Authors: Matheson, P. J., Wilson, M. A., & Garrison, R. N.
Affiliations: University of Louisville (US)
Venue: Journal of Surgical Research
Publisher: Elsevier BV
Published: 2000-09
Volume: 93
Issue: 1
Pages: 182-196
ISSN: 0022-4804 (ISSN-L)
DOI: 10.1006/jsre.2000.5862
OpenAlex: W2120366658
Cited by: 296
References: 148
Citations by year: 2026: 10 · 2025: 8 · 2024: 12 · 2023: 21 · 2022: 14 · 2021: 14 · 2020: 14 · 2019: 10 · 2018: 9 · 2017: 16 · 2016: 13 · 2015: 9 · 2014: 16 · 2013: 12 · 2012: 18
FWCI: 1.01
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of Surgical Research (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Surgery › Abdominal vascular conditions and treatments
Health Sciences › Medicine › Hematology › Blood properties and coagulation
Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Keywords: intestinal blood flow, intestinal perfusion, splanchnic circulation, microvascular blood flow, gastrointestinal barrier function, nutrient absorption, fasting and fed state, pathological stress, gut ischemia
MeSH terms: Animals, Gastrointestinal Hormones, Humans, Hyperemia, Hypertension, Portal, Intestines, Nitric Oxide, Reflex, Regional Blood Flow, Shock, Hemorrhagic, Shock, Septic, Postprandial Period

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Regulation of Intestinal Blood Flow

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