The DOI matches its Crossref record; 143 of the 148 references it cites were found in a registry or an index.
Regulation of Intestinal Blood Flow
Abstract
The gastrointestinal system anatomically is positioned to perform two distinct functions: to digest and absorb ingested nutrients and to sustain barrier function to prevent transepithelial migration of bacteria and antigens. Alterations in these basic functions contribute to a variety of clinical scenarios. These primary functions intrinsically require splanchnic blood flow at both the macrovascular and microvascular levels of perfusion. Therefore, a greater understanding of the mechanisms that regulate intestinal vascular perfusion in the normal state and during pathophysiological conditions would be beneficial. The purpose of this review is to summarize the current understanding regarding the regulatory mechanisms of intestinal blood flow in fasted and fed conditions and during pathological stress.
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“it rapidly becomes clear that the ability to switch metabolism from aerobic to largely nitrate-driven anaerobic is a requirement for microbial survival[267–269].”
From Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health (2017) · cites this paper as [268]
Citations
Cites
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Simulation and prediction of in vivo drug metabolism in human populations from in vitro data
Rostami‐Hodjegan, A., & Tucker, G. T. (2007) · Nature Reviews Drug Discovery · doi:10.1038/nrd2173 · Cited by 533
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Population-Based Mechanistic Prediction of Oral Drug Absorption
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Metadata
- Authors
- Matheson, P. J., Wilson, M. A., & Garrison, R. N.
- Affiliations
- University of Louisville (US)
- Venue
- Journal of Surgical Research
- Publisher
- Elsevier BV
- Published
- 2000-09
- Volume
- 93
- Issue
- 1
- Pages
- 182-196
- ISSN
- 0022-4804 (ISSN-L)
- OpenAlex
- W2120366658
- Cited by
- 296
- References
- 148
- Citations by year
- 2026: 10 · 2025: 8 · 2024: 12 · 2023: 21 · 2022: 14 · 2021: 14 · 2020: 14 · 2019: 10 · 2018: 9 · 2017: 16 · 2016: 13 · 2015: 9 · 2014: 16 · 2013: 12 · 2012: 18
- FWCI
- 1.01
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Surgical Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Abdominal vascular conditions and treatments
- Health Sciences › Medicine › Hematology › Blood properties and coagulation
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- intestinal blood flow, intestinal perfusion, splanchnic circulation, microvascular blood flow, gastrointestinal barrier function, nutrient absorption, fasting and fed state, pathological stress, gut ischemia
- MeSH terms
- Animals, Gastrointestinal Hormones, Humans, Hyperemia, Hypertension, Portal, Intestines, Nitric Oxide, Reflex, Regional Blood Flow, Shock, Hemorrhagic, Shock, Septic, Postprandial Period
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