The DOI matches its Crossref record.
Modelling Morphogenesis: From Single Cells to Crawling Slugs
Open accessAbstract
We present a three-dimensional hybrid cellular automata (CA)/partial differential equation (PDE) model that allows for the study of morphogenesis in simple cellular systems. We apply the model to the cellular slime moldDictyostelium discoideum"from single cells to crawling slug". Using simple local interactions we can achieve the basic morphogenesis with only three processes: production of and chemotaxis to cAMP and cellular adhesion. The interplay of these processes causes the amoebae to spatially self-organize leading to the complex behaviour of stream and mound formation, cell sorting and slug migration all without any change of parameters during the complete morphogenetic process.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Vicsek, T., & Zafeiris, A. (2012) · Physics Reports · doi:10.1016/j.physrep.2012.03.004 · Cited by 2,923
Nonlinear modelling of cancer: bridging the gap between cells and tumours
Lowengrub, J. S., Frieboes, H. B., Jin, F., Chuang, Y.-L., Li, X., Macklin, P., Wise, S. M., & Cristini, V (2010) · Nonlinearity · doi:10.1088/0951-7715/23/1/r01 · Cited by 553
Multi-Scale Modeling of Tissues Using CompuCell3D
Swat, M. H., Thomas, G. L., Belmonte, J. M., Shirinifard, A., Hmeljak, D., & Glazier, J. A. (2012) · Methods in Cell Biology · doi:10.1016/b978-0-12-388403-9.00013-8 · Cited by 511
Picioreanu, C., van Loosdrecht, M. C. M., & Heijnen, J. J. (1998) · Biotechnology and Bioengineering · doi:10.1002/(sici)1097-0290(19980405)58:1<101::aid-bit11>3.0.co;2-m · Cited by 507
Trepat, X., Chen, Z., & Jacobson, K. (2012) · Comprehensive Physiology · doi:10.1002/cphy.c110012 · Cited by 406
Metadata
- Authors
- Savill, N. J., & Hogeweg, P.
- Venue
- Journal of Theoretical Biology
- Publisher
- Elsevier BV
- Published
- 1997-02
- Volume
- 184
- Issue
- 3
- Pages
- 229-235
- ISSN
- 0022-5193 (ISSN-L)
- OpenAlex
- W2041619208
- Cited by
- 276
- References
- 0
- FWCI
- 22.02
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Modelling Morphogenesis: From Single Cells to Crawling Slugs. https://app.cochat.ai/papers/10.1006/jtbi.1996.0237
- The paper
- Savill, N. J., & Hogeweg, P. (1997). Modelling Morphogenesis: From Single Cells to Crawling Slugs. Journal of Theoretical Biology. https://doi.org/10.1006/jtbi.1996.0237
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
