Incorporation and glial differentiation of mouse EGF-responsive neural progenitor cells after transplantation into the embryonic rat brain
Abstract
In vitro, epidermal growth factor (EGF)-responsive neural progenitor cells exhibit multipotent properties and can differentiate into both neurons and glia. Using an in utero xenotransplantation approach we examined the developmental potential of EGF-responsive cells derived from E14 mouse ganglionic eminences, cortical primordium, and ventral mesencephalon, after injection into the E15 rat forebrain ventricle. Cell cultures were established from control mice or from mice carrying the lacZ transgene under control of the promoters for nestin, glial fibrillary acidic protein (GFAP), or myelin basic protein (MBP). The grafted cells, visualized with mouse-specific markers or staining for the reporter gene product, displayed widespread incorporation into distinct forebrain and midbrain structures and differentiated predominantly into glial cells. The patterns of incorporation of cells from all three regions were very similar without preference for the homotopic brain areas. These results suggest that EGF-responsive progenitor cells can respond to host derived environmental cues, differentiate into cells with glial-like features, and become integrated in the developing recipient brain.
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The brain parenchyma outside these niches limits the neurogenic potential of transplanted NSCs or neuroblasts.
“The brain parenchyma outside these niches (e.g., neocortex; Figure 1A) even limits the neurogenic potential of transplanted NSCs or neuroblasts”
From Defining the Adult Neural Stem Cell Niche Proteome Identifies Key Regulators of Adult Neurogenesis (2020) · cites this paper as Winkler et al., 1998
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Self-citationDefining the Adult Neural Stem Cell Niche Proteome Identifies Key Regulators of Adult Neurogenesis
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- Authors
- Winkler, C., Fricker, R. A., Gates, M. A., Olsson, M., Hammang, J. P., Carpenter, M. K., & Björklund, A.
- Affiliations
- Lund University (SE)
- ORCID
- Venue
- Molecular and Cellular Neuroscience
- Publisher
- Elsevier BV
- Published
- 1998-06
- Volume
- 11
- Issue
- 3
- Pages
- 99-116
- ISSN
- 1044-7431 (ISSN-L)
- OpenAlex
- W2081768529
- Cited by
- 127
- References
- 77
- Citations by year
- 2020: 2 · 2019: 1 · 2016: 1 · 2014: 2 · 2013: 1 · 2012: 5
- FWCI
- 3.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular and Cellular Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust
- European Science Foundation
- Knut och Alice Wallenbergs Stiftelse
- Medical Research Council
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Health Sciences › Medicine › Genetics › Glioma Diagnosis and Treatment
- Keywords
- epidermal growth factor, neural progenitor cells, glial differentiation, xenotransplantation, in utero transplantation, ganglionic eminence, ventral mesencephalon, forebrain, midbrain, nestin, glial fibrillary acidic protein, myelin basic protein, lacZ reporter, cell incorporation
- MeSH terms
- Animals, Astrocytes, Cell Differentiation, DNA, Satellite, Myelin Basic Protein, Epidermal Growth Factor, Female, Glial Fibrillary Acidic Protein, Graft Survival, Intermediate Filament Proteins, Lac Operon, Mice, Transgenic, Nerve Tissue Proteins, Neurons, Pregnancy, Stem Cells, Transplantation, Heterologous, Vimentin, Fetal Tissue Transplantation, Brain Tissue Transplantation, In Situ Hybridization, Myelin Proteolipid Protein, Stem Cell Transplantation, Mice, Rats, Nestin
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