Localization and Phosphorylation of Abl-Interactor Proteins, Abi-1 and Abi-2, in the Developing Nervous System
Abstract
Abl-interactor (Abi) proteins are targets of Abl-family nonreceptor tyrosine kinases and are required for Rac-dependent cytoskeletal reorganization in response to growth factor stimulation. We asked if the expression, phosphorylation, and cellular localization of Abi-1 and Abi-2 supports a role for these proteins in Abl signaling in the developing and adult mouse nervous system. In mid- to late-gestation embryos, abi-2 message is elevated in the central and peripheral nervous systems (CNS and PNS). Abi-1 mRNA is present, but not enhanced, in the CNS, and is not observed in PNS structures. Abi proteins from brain lysates undergo changes in apparent molecular weight and phosphorylation with increasing age. In the postnatal brain, abi-1 and abi-2 are expressed most prominently in cortical layers populated by projection neurons. In cultured neurons, Abi-1 and Abi-2 are concentrated in puncta throughout the cell body and processes. Both Abi and Abl proteins are present in synaptosomes and growth cone particles. Therefore, the Abi adaptors exhibit proper expression patterns and subcellular localization to participate in Abl kinase signaling in the nervous system.
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Phosphorylation is key to maintaining stability and function of ABI family proteins.
“It is known that phosphorylation is key to maintaining the stability and function of ABI family of proteins [37, 80].”
From Deletion of Abi3/Gngt2 influences age-progressive amyloid β and tau pathologies in distinctive ways (2022) · cites this paper as [80]
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Grove, M., Demyanenko, G., Echarri, A., Zipfel, P. A., Quiroz, M. E., Rodriguiz, R. M., Playford, M., Martensen, S. A., Robinson, M. R., Wetsel, W. C., et al. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.24.10905-10922.2004 · Cited by 136 · see citing works
Self-citationVessey, J. P., & Karra, D. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04662.x · Cited by 44 · see citing works
Deletion of Abi3/Gngt2 influences age-progressive amyloid β and tau pathologies in distinctive ways
Ibanez, K. R., McFarland, K. N., Phillips, J., Allen, M., Lessard, C. B., Zobel, L., De La Cruz, E. G., Shah, S., Vo, Q., Wang, X., et al. (2022) · Alzheimer's Research & Therapy · doi:10.1186/s13195-022-01044-1 · Cited by 18 · see citing works
- Authors
- Courtney, K. D., Grove, M., Vandongen, H., Vandongen, A., LaMantia, A.-S., & Pendergast, A. M.
- Affiliations
- Duke University (US)
- Duke Medical Center (US)
- University of North Carolina at Chapel Hill (US)
- Corresponding author
- Pendergast, Ann Marie
- Venue
- Molecular and Cellular Neuroscience
- Publisher
- Elsevier BV
- Published
- 2000-09
- Volume
- 16
- Issue
- 3
- Pages
- 244-257
- ISSN
- 1044-7431 (ISSN-L)
- OpenAlex
- W2136718221
- Cited by
- 78
- References
- 0
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 4 · 2023: 2 · 2022: 14 · 2020: 1 · 2019: 1 · 2017: 2 · 2016: 1 · 2015: 2 · 2014: 1 · 2013: 3 · 2012: 2
- FWCI
- 0.91
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular and Cellular Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Vanderbilt University Medical Center
- National Cancer Institute (R01CA070940, CA70940)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- Abi-1, protein phosphorylation, subcellular localization, brain development, postnatal brain, cortical projection neurons, synaptosomes, growth cones, Rac signaling, cytoskeletal remodeling, embryonic nervous system, mRNA expression patterns
- MeSH terms
- Aging, Animals, Animals, Newborn, Cells, Cultured, Cytoskeletal Proteins, Embryo, Mammalian, Embryonic and Fetal Development, Mice, Inbred Strains, Nervous System, Phosphorylation, Subcellular Fractions, Tissue Distribution, Proto-Oncogene Proteins c-abl, Homeodomain Proteins, Adaptor Proteins, Signal Transducing, Mice, Rats
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