More than just synaptic building blocks: scaffolding proteins of the post‐synaptic density regulate dendritic patterning

Vessey, John P.; Karra, Daniela

doi:10.1111/j.1471-4159.2007.04662.x

Cited by 44Neuroscience and Neuropharmacology ResearchAxon Guidance and Neuronal SignalingGenetics and Neurodevelopmental Disorders

More than just synaptic building blocks: scaffolding proteins of the post‐synaptic density regulate dendritic patterning

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Vessey, John P., Karra, Daniela·2007·Journal of Neurochemistry

DOI 10.1111/j.1471-4159.2007.04662.x

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Abstract

The dendritic arbor is responsible for receiving and consolidating neuronal input. Outgrowth and morphogenesis of the arbor are complex stages of development that are poorly understood. However, recent findings have identified synaptic scaffolding proteins as novel regulators of these important events. Scaffolding proteins are enriched in the post‐synaptic density where they bind and bring into close proximity neurotransmitter receptors, signaling molecules, and regulators of the actin cytoskeleton. This property is important for dendritic spine morphogenesis and maintenance in the mature neuron. Scaffolding proteins are now being described as key regulators of neurite outgrowth, dendritic development, and pattern formation in immature neurons. These proteins, which include post‐synaptic‐95, Shank and Densin‐180, as well as many of their interacting partners, appear to regulate both the microtubule and actin cytoskeleton to influence dendrite morphology. Through a large array of protein–protein interaction domains, scaffolding proteins are able to form large macromolecular complexes that include cytoskeletal motor proteins as well as microtubule and actin regulatory molecules. Together, the new findings form a persuasive argument that scaffolding proteins deliver critical regulatory elements to sites of dendritic outgrowth and branching to modulate the formation and maintenance of the dendritic arbor.

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Authors: Vessey, J. P., & Karra, D.
Affiliations: Medical University of Vienna (AT)
Corresponding author: Vessey, John P.
Venue: Journal of Neurochemistry
Publisher: Wiley
Published: 2007-05-10
Volume: 102
Issue: 2
Pages: 324-332
ISSN: 0022-3042 (ISSN-L)
1471-4159
DOI: 10.1111/j.1471-4159.2007.04662.x
OpenAlex: W1954000145
Cited by: 44
References: 89
Citations by year: 2026: 2 · 2024: 2 · 2023: 3 · 2022: 2 · 2020: 5 · 2019: 1 · 2018: 1 · 2017: 3 · 2016: 1 · 2014: 2 · 2013: 3 · 2012: 3
FWCI: 0.31
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Journal of Neurochemistry (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Keywords: dendritic arbor development, dendritic spine morphogenesis, synaptic scaffolding proteins, postsynaptic density, shank, actin cytoskeleton, microtubule cytoskeleton, neurite outgrowth, dendritic branching, protein-protein interaction domains, macromolecular complexes, cytoskeletal motor proteins
MeSH terms: Disks Large Homolog 4 Protein, Animals, Cell Differentiation, Central Nervous System, Cytoskeleton, Dendrites, Humans, Membrane Proteins, Synaptic Membranes, Molecular Motor Proteins, Intracellular Signaling Peptides and Proteins, Cell Shape

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More than just synaptic building blocks: scaffolding proteins of the post‐synaptic density regulate dendritic patterning

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