Cited by 271Sulfur Compounds in BiologyAntioxidant Activity and Oxidative StressRedox biology and oxidative stress

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Glutamine, as a Precursor of Glutathione, and Oxidative Stress

Amores-Sánchez, Marı́a Isabel, Medina, Miguel Ángel·1999·Molecular Genetics and Metabolism

DOI 10.1006/mgme.1999.2857

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Abstract

Oxidative stress is related to several pathologies and it is also associated with surgical operations. Reactive oxygen species generated during oxidative stress can induce severe damage to biomolecules. To prevent this damage, cells are endowed with both enzymatic and nonenzymatic defenses. One of the most important antioxidant molecules is glutathione. Since glutamine is a precursor of glutathione, its supplementation in the clinical diet can be used to maintain high levels of glutathione and to avoid oxidative stress damage. Here, recent literature concerning this recurrent topic is critically reviewed.

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Additional file 17 of Sex, tissue, and mitochondrial interactions modify the transcriptional response to rapamycin in Drosophila
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Additional file 14 of Sex, tissue, and mitochondrial interactions modify the transcriptional response to rapamycin in Drosophila
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Additional file 9 of Sex, tissue, and mitochondrial interactions modify the transcriptional response to rapamycin in Drosophila
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Additional file 12 of Sex, tissue, and mitochondrial interactions modify the transcriptional response to rapamycin in Drosophila
Raynes, Y., Santiago, J. C., Lemieux, F. A., Darwin, L., & Rand, D. M. (2024) · Figshare · doi:10.6084/m9.figshare.26758354
Additional file 6 of Sex, tissue, and mitochondrial interactions modify the transcriptional response to rapamycin in Drosophila
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Additional file 3 of Sex, tissue, and mitochondrial interactions modify the transcriptional response to rapamycin in Drosophila
Raynes, Y., Santiago, J. C., Lemieux, F. A., Darwin, L., & Rand, D. M. (2024) · Figshare · doi:10.6084/m9.figshare.26758327
Additional file 8 of Sex, tissue, and mitochondrial interactions modify the transcriptional response to rapamycin in Drosophila
Raynes, Y., Santiago, J. C., Lemieux, F. A., Darwin, L., & Rand, D. M. (2024) · Figshare · doi:10.6084/m9.figshare.26758342
Additional file 5 of Sex, tissue, and mitochondrial interactions modify the transcriptional response to rapamycin in Drosophila
Raynes, Y., Santiago, J. C., Lemieux, F. A., Darwin, L., & Rand, D. M. (2024) · Figshare · doi:10.6084/m9.figshare.26758333
Additional file 4 of Sex, tissue, and mitochondrial interactions modify the transcriptional response to rapamycin in Drosophila
Raynes, Y., Santiago, J. C., Lemieux, F. A., Darwin, L., & Rand, D. M. (2024) · Figshare · doi:10.6084/m9.figshare.26758330
Additional file 10 of Sex, tissue, and mitochondrial interactions modify the transcriptional response to rapamycin in Drosophila
Raynes, Y., Santiago, J. C., Lemieux, F. A., Darwin, L., & Rand, D. M. (2024) · Figshare · doi:10.6084/m9.figshare.26758348
Additional file 13 of Sex, tissue, and mitochondrial interactions modify the transcriptional response to rapamycin in Drosophila
Raynes, Y., Santiago, J. C., Lemieux, F. A., Darwin, L., & Rand, D. M. (2024) · Figshare · doi:10.6084/m9.figshare.26758357
Additional file 16 of Sex, tissue, and mitochondrial interactions modify the transcriptional response to rapamycin in Drosophila
Raynes, Y., Santiago, J. C., Lemieux, F. A., Darwin, L., & Rand, D. M. (2024) · Figshare · doi:10.6084/m9.figshare.26758366
Additional file 18 of Sex, tissue, and mitochondrial interactions modify the transcriptional response to rapamycin in Drosophila
Raynes, Y., Santiago, J. C., Lemieux, F. A., Darwin, L., & Rand, D. M. (2024) · Figshare · doi:10.6084/m9.figshare.26758372
Additional file 2 of Sex, tissue, and mitochondrial interactions modify the transcriptional response to rapamycin in Drosophila
Raynes, Y., Santiago, J. C., Lemieux, F. A., Darwin, L., & Rand, D. M. (2024) · Figshare · doi:10.6084/m9.figshare.26507305
Additional file 15 of Sex, tissue, and mitochondrial interactions modify the transcriptional response to rapamycin in Drosophila
Raynes, Y., Santiago, J. C., Lemieux, F. A., Darwin, L., & Rand, D. M. (2024) · Figshare · doi:10.6084/m9.figshare.26758363
Additional file 7 of Sex, tissue, and mitochondrial interactions modify the transcriptional response to rapamycin in Drosophila
Raynes, Y., Santiago, J. C., Lemieux, F. A., Darwin, L., & Rand, D. M. (2024) · Figshare · doi:10.6084/m9.figshare.26758339
Additional file 11 of Sex, tissue, and mitochondrial interactions modify the transcriptional response to rapamycin in Drosophila
Raynes, Y., Santiago, J. C., Lemieux, F. A., Darwin, L., & Rand, D. M. (2024) · Figshare · doi:10.6084/m9.figshare.26758351
Additional file 1 of Sex, tissue, and mitochondrial interactions modify the transcriptional response to rapamycin in Drosophila
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Authors: Amores-Sánchez, M. I., & Medina, M. Á.
Affiliations: Universidad de Málaga (ES)
Corresponding author: Medina, Miguel Ángel
ORCID: Medina, Miguel Ángel
Venue: Molecular Genetics and Metabolism
Publisher: Elsevier BV
Published: 1999-06
Volume: 67
Issue: 2
Pages: 100-105
ISSN: 1096-7192 (ISSN-L)
DOI: 10.1006/mgme.1999.2857
OpenAlex: W2044158587
Cited by: 261
References: 48
Citations by year: 2026: 23 · 2025: 19 · 2024: 21 · 2023: 18 · 2022: 17 · 2021: 18 · 2020: 10 · 2019: 9 · 2018: 9 · 2017: 9 · 2016: 12 · 2015: 13 · 2014: 7 · 2013: 6 · 2012: 9
FWCI: 2.02
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Molecular Genetics and Metabolism (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Sulfur Compounds in Biology
Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Keywords: glutamine, glutathione, oxidative stress, reactive oxygen species, antioxidant defense, glutathione synthesis, dietary supplementation, biomolecule damage
MeSH terms: Glutamine, Glutathione, Humans, Protein Precursors, Oxidative Stress

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Glutamine, as a Precursor of Glutathione, and Oxidative Stress

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