Cited by 271Sulfur Compounds in BiologyAntioxidant Activity and Oxidative StressRedox biology and oxidative stress

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Glutamine, as a Precursor of Glutathione, and Oxidative Stress

Amores-Sánchez, Marı́a Isabel, Medina, Miguel Ángel·1999·Molecular Genetics and Metabolism

DOI 10.1006/mgme.1999.2857

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Abstract

Oxidative stress is related to several pathologies and it is also associated with surgical operations. Reactive oxygen species generated during oxidative stress can induce severe damage to biomolecules. To prevent this damage, cells are endowed with both enzymatic and nonenzymatic defenses. One of the most important antioxidant molecules is glutathione. Since glutamine is a precursor of glutathione, its supplementation in the clinical diet can be used to maintain high levels of glutathione and to avoid oxidative stress damage. Here, recent literature concerning this recurrent topic is critically reviewed.

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Incidence and recognition of malnutrition in hospital
McWhirter, J. P., & Pennington, C. R. (1994) · BMJ · doi:10.1136/bmj.308.6934.945 · Cited by 1,504
Amino Acid Metabolism in Man
Felig, P. (1975) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.44.070175.004441 · Cited by 789
Clinical and Metabolic Efficacy of Glutamine-supplemented Parenteral Nutrition after Bone Marrow Transplantation
Ziegler, T. R., Young, L. S., Benfell, K., Scheltinga, M. R., Hortos, K., BYE, R. L., Morrow, F. D., Jacobs, D. O., Smith, R. J., Antin, J. H., et al. (1992) · Annals of Internal Medicine · doi:10.7326/0003-4819-116-10-821 · Cited by 752
Glutamine and the preservation of gut integrity
van der Hulst, R. R. W. J., von Meyenfeldt, M. F., Deutz, N. E. P., Soeters, P. B., Brummer, R. J. M., von Kreel, B. K., & Arends, J. W. (1993) · The Lancet · doi:10.1016/0140-6736(93)90939-e · Cited by 657
Six-month outcome of critically ill patients given glutamine-supplemented parenteral nutrition
Griffiths, R., Jones, C., & Palmer, T. E. A. (1997) · Nutrition · doi:10.1016/s0899-9007(97)00017-8 · Cited by 538
Natural Antioxidants in Human Health and Disease
(1994) · Elsevier eBooks · doi:10.1016/c2009-0-03361-3 · Cited by 428
Antioxidants in Nutrition, Health, and Disease
Gutteridge, J. M. C., & Halliwell, B. B. (1995) · doi:10.1093/oso/9780198549024.001.0001 · Cited by 308
Free radicals : a practical approach
Punchard, N. A., & Kelly, F. J. (1996) · Oxford University Press eBooks · Cited by 285
Glutamine Preserves Liver Glutathione After Lethal Hepatic Injury
HONG, R. W., Rounds, J. D., Helton, W. S., ROBINSON, M. K., & Wilmore, D. W. (1992) · Annals of Surgery · doi:10.1097/00000658-199202000-00004 · Cited by 251
The acute respiratory distress syndrome: Definitions, severity and clinical outcome An analysis of 101 clinical investigations
Krafft, P., Fridrich, P., Pernerstorfer, T., Fitzgerald, R. D., Koç, D., Schneider, B., Hammerle, A. F., & Steltzer, H. (1996) · Intensive Care Medicine · doi:10.1007/bf01708091 · Cited by 244

Show all 48 references

Research works printed but not linked: 2

Okawa, 1996, Influence of total parenteral nutrition in immature rats: Effect of glutamine infusion on bowel integrity (in Japanese), Hokkaido Igaku Zasshi, 71, 55
Packer, 1996, Nitric oxide, Methods Enzymol, 269

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Mühling, J., Fuchs, M., Fleck, C., Sablotzki, A., Krüll, M., Dehne, M. G., Gonter, J., Weiss, S., Engel, J., & Hempelmann, G. (2002) · Amino Acids · doi:10.1007/s726-002-8200-9 · Cited by 29
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Tabuchi, H., Sugiyama, T., Tanaka, S., & Tainaka, S. (2010) · Biotechnology and Bioengineering · doi:10.1002/bit.22880 · Cited by 28
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Authors: Amores-Sánchez, M. I., & Medina, M. Á.
Affiliations: Universidad de Málaga (ES)
Corresponding author: Medina, Miguel Ángel
ORCID: Medina, Miguel Ángel
Venue: Molecular Genetics and Metabolism
Publisher: Elsevier BV
Published: 1999-06
Volume: 67
Issue: 2
Pages: 100-105
ISSN: 1096-7192 (ISSN-L)
DOI: 10.1006/mgme.1999.2857
OpenAlex: W2044158587
Cited by: 261
References: 48
Citations by year: 2026: 23 · 2025: 19 · 2024: 21 · 2023: 18 · 2022: 17 · 2021: 18 · 2020: 10 · 2019: 9 · 2018: 9 · 2017: 9 · 2016: 12 · 2015: 13 · 2014: 7 · 2013: 6 · 2012: 9
FWCI: 2.02
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Molecular Genetics and Metabolism (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Sulfur Compounds in Biology
Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Keywords: glutamine, glutathione, oxidative stress, reactive oxygen species, antioxidant defense, glutathione synthesis, dietary supplementation, biomolecule damage
MeSH terms: Glutamine, Glutathione, Humans, Protein Precursors, Oxidative Stress

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Glutamine, as a Precursor of Glutathione, and Oxidative Stress

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