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Comparison of Impaired Subcortico-Frontal Metabolic Networks in Normal Aging, Subcortico-Frontal Dementia, and Cortical Frontal Dementia
Open accessAbstract
Normal aging, progressive supranuclear palsy (PSP), and frontotemporal dementia (FTD) are characterized by different degrees of decline in frontal lobe functions. We used (18)FDG-PET and statistical parametric mapping (SPM96) to compare relative subcorticofrontal metabolic impairment at rest in 21 healthy elderly subjects (HES), 20 PSP patients, and 6 FTD patients. When HES were compared to 22 healthy young subjects, widespread decrease in metabolism was observed in bilateral medial prefrontal areas including anterior cingulate cortices, in dorsolateral prefrontal areas, in left lateral premotor area, in Broca's area, and in left insula. In PSP compared to the 43 healthy subjects (HS), we observed subcorticofrontal metabolic impairment including both motor and cognitive neural networks. Impairment of functional connections between midbrain tegmentum and cerebellar, temporal and pallidal regions was demonstrated in PSP as compared to HS. When comparing FTD to HS, glucose uptake was primarily reduced in dorsolateral and ventrolateral prefrontal cortices and in frontopolar and anterior cingulate regions. There was also bilateral anterior temporal, right inferior parietal, and bilateral striatal hypometabolism. Finally, FTD showed more severe striatofrontal metabolic impairment than PSP, while mesencephalothalamic involvement was only observed in PSP. Our data suggest that subcorticofrontal metabolic impairment is distributed in distinct subcorticocortical networks in normal aging, PSP, and FTD. Subcorticofrontal dementia in PSP is related to hypometabolism in discrete frontal areas, which are probably disconnected from certain subcortical structures. The concept of subcortical dementia is reinforced by our data, which show disrupted functional connections between mesencephalon and cerebellar cortex, inferior and medial temporal regions, and pallidum.
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Ruffman, T., Henry, J. D., Livingstone, V., & Phillips, L. H. (2008) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.01.001 · Cited by 984
“Similarly, one might posit that older adults would have difficulty recognising facial expressions of sadness given volume reductions and metabolic decline in the anterior cingulate cortex (Convit et al., 2001; Garraux et al., 1999; Ohnishi et al., 2001; Pardo et al., 2007; Petit-Taboué et al., 1998; Resnick et al., 20…”
BackgroundDiscrimination between Alzheimer dementia and controls by automated analysis of multicenter FDG PET
Herholz, K., Salmon, E., Perani, D., Baron, J.-C., Holthoff, V., Frölich, L., Schönknecht, P., Ito, K., Mielke, R., & Kalbe, E. (2002) · NeuroImage · doi:10.1006/nimg.2002.1208 · Cited by 832
“Similar effects of normal aging on CMRGlc had been described before (Kuhl et al., 1984; Petit-Taboue et al., 1998; Garraux et al., 1999), but had not yet been compared directly to AD-related changes.”
ResultSelf-citationMacPherson, S. E., Phillips, L. H., & Sala, S. D. (2002) · Psychology and Aging · doi:10.1037/0882-7974.17.4.598 · Cited by 626
“Few neuroimaging studies have distinguished between age effects on the DL and VM areas; however, those studies that do have reported that the glucose metabolism at rest in the DL region is significantly correlated with age while the glucose metabolism at rest in the VM region is not (Duara et al., 1983; Garraux et al.…”
BackgroundVoxel-based mapping of brain gray matter volume and glucose metabolism profiles in normal aging
Kalpouzos, G., Chételat, G., Baron, J.-C., Landeau, B., Mevel, K., Godeau, C., Barré, L., Constans, J.-M., Viader, F., Eustache, F., et al. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.05.019 · Cited by 392
“Resting-state SPECT and PET studies have consistently highlighted a metabolic deterioration of the frontal and anterior cingulate cortices [12,28,32,42,44, 48,49,54,58,86,87,89].”
BackgroundMethodNeurophysiological signals of working memory in normal aging
McEvoy, L. K., Pellouchoud, E., Smith, M. E., & Gevins, A. S. (2001) · Cognitive Brain Research · doi:10.1016/s0926-6410(01)00009-x · Cited by 323
Metadata
- Authors
- Garraux, G., Salmon, E., Degueldre, C., Lemaire, C., Laureys, S., & Franck, G.
- Affiliations
- University of Liège (BE)
- Venue
- NeuroImage
- Publisher
- Elsevier BV
- Published
- 1999-08
- Volume
- 10
- Issue
- 2
- Pages
- 149-162
- ISSN
- 1053-8119 (ISSN-L)
- OpenAlex
- W2149544109
- Cited by
- 109
- References
- 0
- Citations by year
- 2026: 1 · 2024: 2 · 2023: 1 · 2021: 2 · 2020: 3 · 2019: 5 · 2018: 2 · 2017: 3 · 2016: 4 · 2015: 2 · 2014: 4 · 2013: 2 · 2012: 7
- FWCI
- 4.96
- Type
- journal article
- Language
- en
- Open access
- green
- orbi.uliege.be
- Licence
- Locations
- NeuroImage (publishedVersion)
- PubMed (publishedVersion)
- ORBi (University of Liège) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
- Keywords
- subcortical dementia, progressive supranuclear palsy, frontotemporal dementia, normal aging, glucose hypometabolism, medial prefrontal cortex, anterior cingulate cortex, dorsolateral prefrontal cortex, striatum, cerebellum, globus pallidus, temporal lobe
- MeSH terms
- Adult, Aged, Blood Glucose, Brain, Brain Mapping, Cerebellum, Dementia, Dominance, Cerebral, Energy Metabolism, Female, Frontal Lobe, Globus Pallidus, Humans, Image Processing, Computer-Assisted, Male, Mesencephalon, Middle Aged, Nerve Net, Reference Values, Supranuclear Palsy, Progressive, Tegmentum Mesencephali, Temporal Lobe, Tomography, Emission-Computed
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