The DOI matches its Crossref record; 63 of the 64 references it cites were found in a registry or an index.
Role of Operculoinsular Cortices in Human Pain Processing: Converging Evidence from PET, fMRI, Dipole Modeling, and Intracerebral Recordings of Evoked Potentials
Abstract
Insular and SII cortices have been consistently shown by PET, fMRI, EPs, and MEG techniques to be activated bilaterally by a nociceptive stimulation. The aim of the present study was to refer to, and to compare within a common stereotactic space, the nociceptive responses obtained in humans by (i) PET, (ii) fMRI, (iii) dipole modeling of scalp LEPs, and (iv) intracerebral recordings of LEPs. PET, fMRI, and scalp LEPs were obtained from normal subjects during thermal pain. Operculoinsular LEPs were obtained from 13 patients using deep brain electrodes implanted for presurgical evaluation of drug-resistant epilepsy. Whatever the technique, we obtained responses which were located bilaterally in the insular and SII cortices. In electrophysiological responses (LEPs) the SII insular contribution peaked between 150 and 250 ms poststimulus and corresponded to the earliest portions of the whole cerebral response. Group analysis of PET and fMRI data showed highly consistent responses contralateral to stimulation. On single-subject analysis, LEPs and fMRI activations were concentrated in relatively restricted volumes even though spatial sampling was quite different for both techniques. Despite our multimodal approach, however, it was not possible to separate insular from SII activities. Individual variations in the anatomy and function of SII and insular cortices may explain this limitation. This multimodal study provides, however, cross-validated spatial and temporal information on the pain-related processes occurring in the operculoinsular region, which thus appears as a major site for the early cortical pain encoding in the human brain.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“In humans, intranasal oxytocin has been shown to increase rCBF, and hence neuronal activity, in cortical areas directly implicated in the processing of nociceptive input and the experience of pain, as well as in the descending modulation of nociceptive input, such as the frontoparietal opercula, the insula and the anterior cingulate cortex 58, 66, 67.”
From The Analgesic Effect of Oxytocin in Humans: A Double‐Blind, Placebo‐Controlled Cross‐Over Study Using Laser‐Evoked Potentials (2016) · cites this paper as [66]
Citations
Cites
Co-Planar Stereotaxic Atlas of the Human Brain
Talairach, J., & Tournoux, P. (1988) · Medical Entomology and Zoology · Cited by 11,798
Co-planar stereotaxic atlas of the human brain
Laitinen, L. (1989) · Clinical Neurology and Neurosurgery · doi:10.1016/0303-8467(89)90128-5 · Cited by 7,565
Spatial registration and normalization of images
Friston, K. J., Ashburner, J., Frith, C., Poline, J.-B., Heather, J. D., & Frackowiak, R. S. J. (1995) · Human Brain Mapping · doi:10.1002/hbm.460030303 · Cited by 3,744
Pain Affect Encoded in Human Anterior Cingulate But Not Somatosensory Cortex
Rainville, P., Duncan, G. H., Price, D. D., Carrier, B., & Bushnell, M. C. (1997) · Science · doi:10.1126/science.277.5328.968 · Cited by 2,629
Functional imaging of brain responses to pain. A review and meta-analysis (2000)
Peyron, R., Laurent, B., & García-Larrea, L. (2000) · Neurophysiologie Clinique/Clinical Neurophysiology · doi:10.1016/s0987-7053(00)00227-6 · Cited by 2,171
Self-citationCircuitry and functional aspects of the insular lobe in primates including humans
AUGUSTINE, J. (1996) · Brain Research Reviews · doi:10.1016/s0165-0173(96)00011-2 · Cited by 1,776
Pain intensity processing within the human brain: a bilateral, distributed mechanism
Coghill, R. C., Sang, C. N., Maisog, J. M., & Iadarola, M. J. (1999) · Journal of Neurophysiology · doi:10.1152/jn.1999.82.4.1934 · Cited by 1,077
Thermosensory activation of insular cortex
Craig, A. D., Chen, K., Bandy, D., & Reiman, E. M. (2000) · Nature Neuroscience · doi:10.1038/72131 · Cited by 1,004
Multiple Representations of Pain in Human Cerebral Cortex
Talbot, J. D., Marrett, S., Evans, A. C., Meyer, E., Bushnell, M. C., & Duncan, G. H. (1991) · Science · doi:10.1126/science.2003220 · Cited by 969
Brain blood flow measured with intravenous H2(15)O. I. Theory and error analysis.
Herscovitch, P., Markham, J., & Raichle, M. E. (1983) · PubMed · Cited by 835
Flagged first, then by citations
1 of the 64 references couldn’t be matched to a known paper.
Research works printed but not linked: 2
- Herscovitch, 1983, Brain blood flow measured with intravenous H215.O.1. Theory and error analysis, J. Nucl. Med., 24, 782
- Peyron, R, Schneider, F, Giraux, P, Costes, N, Garcı̀a-Larrea, L, Convers, P, Barral, F. G, Michel, D, and, Laurent, B. 2000b, Brain responses to thermal pain in normals: A comparison of PET and 1 Tesla fMRI results. In, Society for Neuroscience Proceedings, Vol, I, pp, 442, New Orleans.
Cited by
Sorted by citations
Items 201–209 of 209
Insular Cortex, Neurophysiology, and Functional Imaging of Nociceptive Processing
Casey, K. L., & Tran, T. D. (2013) · Springer eBooks · doi:10.1007/978-3-642-28753-4_1982
Cortical and Limbic Mechanisms Mediating Pain and Pain-Related Behavior
Casey, K. L. (2013) · Springer eBooks · doi:10.1007/978-3-642-28753-4_889
Hewitt, D., Newton‐Fenner, A., Henderson, J. R., Fallon, N. B., Brown, C. A., & Stančák, A. (2022) · Journal of Neurophysiology · doi:10.1152/jn.00511.2021 · Cited by 1
Nagasaka, K., Takashima, I., Matsuda, K., & Higo, N. (2023) · Douleur et Analgésie · doi:10.3166/dea-2022-0247
Cormie, M. A., & Moayedi, M. (2024) · Pain · doi:10.1097/j.pain.0000000000003172
El núcleo ventromedial posterior del tálamo (VMpo) y un nuevo paradigma en la fisiología del dolor
Serrano, L. E., Casnati, F., & Cremaschi, F. (2015) · NeuroTarget · doi:10.47924/neurotarget2015209
Kamping, S., & Flor, H. (2010) · Springer eBooks · doi:10.1007/978-3-642-05468-6_10
Rôle du cortex operculo-insulaire dans la somesthésie et la douleur chez l'homme
Mazzola, L. (2011) · theses.fr (ABES) · doi:10.70675/f9645b1az7f3ez481cz837cze0e7ac24a2a2
Neurobiological regret and rejoice functions for aversive outcomes
Chandrasekhar, P. V. S., Capra, C. M., Moore, S., NOUSSAIR, C. N., & Berns, G. S. (2008) · Research portal (Tilburg University)
Metadata
- Authors
- Peyron, R., Frot, M., Schneider, F., Garcia-Larrea, L., Mertens, P., Barral, F. G., Sindou, M., Laurent, B., & Mauguière, F.
- Affiliations
- Lyon 1 Université (FR)
- Corresponding author
- Peyron, R.
- Venue
- NeuroImage
- Publisher
- Elsevier BV
- Published
- 2002-11
- Volume
- 17
- Issue
- 3
- Pages
- 1336-1346
- ISSN
- 1053-8119 (ISSN-L)
- OpenAlex
- W1989396758
- Cited by
- 209
- References
- 64
- Citations by year
- 2026: 1 · 2024: 4 · 2023: 5 · 2022: 3 · 2021: 4 · 2020: 7 · 2019: 11 · 2018: 4 · 2017: 4 · 2016: 7 · 2015: 7 · 2014: 3 · 2013: 11 · 2012: 6
- FWCI
- 8.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- NeuroImage (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
- Life Sciences › Neuroscience › Cognitive Neuroscience › Pain Management and Placebo Effect
- Keywords
- pain processing, somatosensory cortex, insula, secondary somatosensory cortex, nociception, thermal pain, dipole modeling, intracerebral recordings, PET, functional MRI, multimodal neuroimaging, individual anatomical variation
- MeSH terms
- Adult, Brain Mapping, Cerebral Cortex, Dominance, Cerebral, Electrodes, Implanted, Electroencephalography, Epilepsy, Temporal Lobe, Female, Frontal Lobe, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged, Synaptic Transmission, Nociceptors, Oxygen, Pain, Tomography, Emission-Computed, Pain Threshold
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
