Cited by 1,004Tactile and Sensory InteractionsPain Mechanisms and TreatmentsIon Channels and Receptors

Thermosensory activation of insular cortex

Craig, A. D., Chen, K., Bandy, D., Reiman, E. M.·2000·Nature Neuroscience

Abstract

Temperature sensation is regarded as a submodality of touch, but evidence suggests involvement of insular cortex rather than parietal somatosensory cortices. Using positron emission tomography (PET), we found contralateral activity correlated with graded cooling stimuli only in the dorsal margin of the middle/posterior insula in humans. This corresponds to the thermoreceptive- and nociceptive-specific lamina I spinothalamocortical pathway in monkeys, and can be considered an enteroceptive area within limbic sensory cortex. Because lesions at this site can produce the post-stroke central pain syndrome, this finding supports the proposal that central pain results from loss of the normal inhibition of pain by cold. Notably, perceived thermal intensity was well correlated with activation in the right (ipsilateral) anterior insular and orbitofrontal cortices.

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Crossref · 10.1038/72131

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  • The perspective on AIC as part of hierarchical predictive coding explains AIC involvement across low-level autonomic and sensorimotor to high-level cognitive and social domains.

    “This perspective on the AIC as an integral part of hierarchical predictive coding in the brain explains the involvement of AIC across low-level autonomic and sensorimotor (Craig et al., 2000; Sterzer and Kleinschmidt, 2010; Fan et al., 2012) to high-level cognitive and social (Montague and Lohrenz, 2007; King-Casas et al., 2008; Bossaerts, 2010; Kirk et al., 2011) domains.”

    From Anterior insular cortex and emotional awareness (2013) · cites this paper as Craig et al., 2000

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Authors
Craig, A. D., Chen, K., Bandy, D., & Reiman, E. M.
Affiliations
  • Barrow Neurological Institute (US)
  • Good Samaritan Regional Medical Center (US)
  • University of Arizona (US)
Corresponding author
Craig, A. D.
Venue
Nature Neuroscience
Published
2000-02
Volume
3
Issue
2
Pages
184-190
ISSN
  • 1097-6256 (ISSN-L)
  • 1546-1726
OpenAlex
W1990876814
Cited by
1,004
References
1
Citations by year
2026: 15 · 2025: 34 · 2024: 38 · 2023: 36 · 2022: 31 · 2021: 44 · 2020: 48 · 2019: 34 · 2018: 40 · 2017: 40 · 2016: 44 · 2015: 53 · 2014: 46 · 2013: 43 · 2012: 46
FWCI
15.59
Type
journal article
Language
en
Open access
closed
Locations
  • Nature Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Tactile and Sensory Interactions
  • Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
  • Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
Keywords
thermosensation, insula, nociception, central pain, stroke, anterior insula, orbitofrontal cortex, somatosensory cortex
MeSH terms
Adult, Brain Mapping, Cerebral Cortex, Cerebrovascular Circulation, Cold Temperature, Differential Threshold, Female, Hand, Humans, Male, Middle Aged, Pain Measurement, Physical Stimulation, Thermosensing, Tomography, Emission-Computed, Linear Models, Prosencephalon

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