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Cited by 35Neurotransmitter Receptor Influence on BehaviorMemory and Neural MechanismsNeuroscience and Neuropharmacology Research

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Dose-Dependent Impairing Effects of Morphine on Avoidance Acquisition and Performance in Male Mice

Aguilar, M.A., Miñarro, J., Simón, V.M.·1998·Neurobiology of Learning and Memory
DOI 10.1006/nlme.1997.3804
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Abstract

The effects of morphine (6.3, 12.6, and 25.2 mg/kg) on active avoidance behavior of BALB/C mice are explored in three acquisition sessions and in two subsequent performance sessions. Morphine-treated animals showed an increase in avoidance acquisition with respect to control group without differences in performance. However, a dramatical, concomitant rise in the locomotor activity of the animals (increase in the number of crossings during the intertrial intervals) prompted us to transform the data employing a formula with which a measure of actual learning was obtained. Applying this formula, we have observed that morphine administration impairs, dose-dependently, acquisition and performance of avoidance. Thus, the impairing effects of morphine on avoidance could be masked by their stimulant effects on locomotor activity.

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Research works printed but not linked: 40

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Metadata

Authors
Aguilar, M. A., Miñarro, J., & Simón, V. M.
Affiliations
Universitat de València (ES)
ORCID
Venue
Neurobiology of Learning and Memory
Publisher
Elsevier BV
Published
1998-03
Volume
69
Issue
2
Pages
92-105
ISSN
1074-7427 (ISSN-L)
DOI
10.1006/nlme.1997.3804
OpenAlex
W2012183209
Cited by
35
References
0
Citations by year
2026: 1 · 2024: 1 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 3 · 2014: 2 · 2013: 2 · 2012: 1
FWCI
0.67
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Neurobiology of Learning and Memory (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
morphine, active avoidance, avoidance acquisition, locomotor activity, dose-dependent effects, learning disabilities, stimulant effects, BALB/c mice
MeSH terms
Animals, Avoidance Learning, Behavior, Animal, Dose-Response Relationship, Drug, Male, Mice, Inbred BALB C, Morphine, Narcotics, Time Factors, Mice

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