Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats.
Open accessAbstract
The effect of various drugs on the extracellular concentration of dopamine in two terminal dopaminergic areas, the nucleus accumbens septi (a limbic area) and the dorsal caudate nucleus (a subcortical motor area), was studied in freely moving rats by using brain dialysis. Drugs abused by humans (e.g., opiates, ethanol, nicotine, amphetamine, and cocaine) increased extracellular dopamine concentrations in both areas, but especially in the accumbens, and elicited hypermotility at low doses. On the other hand, drugs with aversive properties (e.g., agonists of kappa opioid receptors, U-50,488, tifluadom, and bremazocine) reduced dopamine release in the accumbens and in the caudate and elicited hypomotility. Haloperidol, a neuroleptic drug, increased extracellular dopamine concentrations, but this effect was not preferential for the accumbens and was associated with hypomotility and sedation. Drugs not abused by humans [e.g., imipramine (an antidepressant), atropine (an antimuscarinic drug), and diphenhydramine (an antihistamine)] failed to modify synaptic dopamine concentrations. These results provide biochemical evidence for the hypothesis that stimulation of dopamine transmission in the limbic system might be a fundamental property of drugs that are abused.
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Kelly, P. H., Seviour, P. W., & Iversen, S. D. (1975) · Brain Research · doi:10.1016/0006-8993(75)90233-4 · Cited by 1,740 · see citing works
Striatal Dopamine Release after Amphetamine or Nerve Degeneration Revealed by Rotational Behaviour
Ungerstedt, U. (1971) · Acta Physiologica Scandinavica · doi:10.1111/j.1365-201x.1971.tb10999.x · Cited by 924 · see citing works
U-50,488: a selective and structurally novel non-Mu (kappa) opioid agonist.
VonVoigtlander, P. F., Lahti, R. A., & Ludens, J. H. (1983) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)33422-1 · Cited by 814 · see citing works
Self-administration of psychoactive substances by the monkey
Deneau, G. A., Yanagita, T., & Seevers, M. H. (1969) · Psychopharmacology · doi:10.1007/bf00405254 · Cited by 811 · see citing works
Pettit, H. O., Ettenberg, A., Bloom, F. E., & Koob, G. F. (1984) · Psychopharmacology · doi:10.1007/bf00427441 · Cited by 651 · see citing works
Zetterström, T., Sharp, T., Marsden, C. A., & Ungerstedt, U. (1983) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1983.tb00893.x · Cited by 616 · see citing works
Mucha, R. F., & Herz, A. (1985) · Psychopharmacology · doi:10.1007/bf00432213 · Cited by 515 · see citing works
Intracranial self-administration of morphine into the ventral tegmental area in rats
Bozarth, M. A., & Wise, R. A. (1981) · Life Sciences · doi:10.1016/0024-3205(81)90148-x · Cited by 503 · see citing works
Impérato, A., & Chiara, G. D. (1984) · Journal of Neuroscience · doi:10.1523/jneurosci.04-04-00966.1984 · Cited by 456 · see citing works
Matthews, R. T., & German, D. C. (1984) · Neuroscience · doi:10.1016/0306-4522(84)90048-4 · Cited by 426 · see citing works
Dopaminergic substrates of amphetamine-induced place preference conditioning
Spyraki, C., Fibiger, H. C., & Phillips, A. G. (1982) · Brain Research · doi:10.1016/0006-8993(82)90685-0 · Cited by 382 · see citing works
Attenuation of intravenous amphetamine reinforcement by central dopamine blockade in rats
Yokel, R. A., & Wise, R. A. (1976) · Psychopharmacology · doi:10.1007/bf00496868 · Cited by 369 · see citing works
Bremazocine: A potent, long-acting opiate kappa-agonist
Römer, D., Büscher, H. H., Hill, R. C., et al. (1980) · Life Sciences · doi:10.1016/0024-3205(80)90107-1 · Cited by 315 · see citing works
Impérato, A., & Chiara, G. D. (1985) · Journal of Neuroscience · doi:10.1523/jneurosci.05-02-00297.1985 · Cited by 310 · see citing works
Portoghese, P. S., Larson, D. L., Sayre, L. M., et al. (1980) · Journal of Medicinal Chemistry · doi:10.1021/jm00177a002 · Cited by 291 · see citing works
Spyraki, C., Fibiger, H. C., & Phillips, A. G. (1982) · Brain Research · doi:10.1016/0006-8993(82)90686-2 · Cited by 242 · see citing works
Ethanol stimulates the firing rate of nigral dopaminergic neurons in unanesthetized rats
Mereu, G., Fadda, F., & Gessa, G. L. (1984) · Brain Research · doi:10.1016/0006-8993(84)90890-4 · Cited by 209 · see citing works
Römer, D., Büscher, H. H., Hill, R. C., Maurer, R., Petcher, T. J., Zeugner, H., Benson, W., Finner, E., Milkowski, W., & Thies, P. W. (1982) · Nature · doi:10.1038/298759a0 · Cited by 200 · see citing works
Action of drugs of abuse on brain reward systems: An update with specific attention to opiates
Wise, R. A., & Bozarth, M. A. (1982) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(82)90076-4 · Cited by 194 · see citing works
Pharmacologic characterization of nicotine-induced conditioned place preference
Fudala, P. J., Teoh, K., & Iwamoto, E. T. (1985) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(85)90384-3 · Cited by 190 · see citing works
Mackey, W. B., & van der Kooy, D. (1985) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(85)90492-7 · Cited by 179 · see citing works
Attenuation by haloperidol of place preference conditioning using food reinforcement
Spyraki, C., Fibiger, H. C., & Phillips, A. G. (1982) · Psychopharmacology · doi:10.1007/bf00432775 · Cited by 176 · see citing works
Electrophysiological actions of nicotine on substantia nigra single units
Clarke, P. B. S., Hommer, D. W., Pert, A., & Skirboll, L. R. (1985) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1985.tb11081.x · Cited by 170 · see citing works
Reid, L. D., Hunter, G. A., Beaman, C. M., & Hubbell, C. L. (1985) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(85)90051-6 · Cited by 144 · see citing works
Behavioral effects of a novel kappa opioid analgesic, U-50488, in rats and rhesus monkeys
Tang, A. H., & Collins, R. J. (1985) · Psychopharmacology · doi:10.1007/bf00428193 · Cited by 85 · see citing works
Mucha, R. F., & Herz, A. (1986) · Life Sciences · doi:10.1016/0024-3205(86)90309-7 · Cited by 57 · see citing works
Stewart, R. B., & Grupp, L. A. (1985) · Psychopharmacology · doi:10.1007/bf00431776 · Cited by 46 · see citing works
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Sorted by citations
The neural basis of drug craving: An incentive-sensitization theory of addiction
Robinson, T. (1993) · Brain Research Reviews · doi:10.1016/0165-0173(93)90013-p · Cited by 7,346 · see citing works
Koob, G. F., & Volkow, N. D. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.110 · Cited by 5,340 · see citing works
What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience?
Berridge, K. C., & Robinson, T. E. (1998) · Brain Research Reviews · doi:10.1016/s0165-0173(98)00019-8 · Cited by 4,127 · see citing works
Dopamine, learning and motivation.
Wise, R. A. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1406 · Cited by 3,379 · see citing works
Dysfunction of the prefrontal cortex in addiction: neuroimaging findings and clinical implications
Goldstein, R. Z., & Volkow, N. D. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3119 · Cited by 2,749 · see citing works
Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter
Giros, B., Jaber, M., Jones, S. R., Wightman, R. M., & Caron, M. G. (1996) · Nature · doi:10.1038/379606a0 · Cited by 2,476 · see citing works
Cannabinoid receptor localization in brain.
Herkenham, M., Lynn, A. B., Little, M. D., Johnson, M. R., Melvin, L. S., de Costa, B. R., & Rice, K. C. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.5.1932 · Cited by 2,321 · see citing works
Chronic stress, drug use, and vulnerability to addiction
Sinha, R. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1441.030 · Cited by 1,904 · see citing works
The induction of pain: an integrative review
Millan, M. J. (1999) · Progress in Neurobiology · doi:10.1016/s0301-0082(98)00048-3 · Cited by 1,774 · see citing works
Opioids excite dopamine neurons by hyperpolarization of local interneurons
Johnson, S., & North, R. (1992) · The Journal of Neuroscience · doi:10.1523/jneurosci.12-02-00483.1992 · Cited by 1,637 · see citing works
Jentsch, J. D., & Taylor, J. R. (1999) · Psychopharmacology · doi:10.1007/pl00005483 · Cited by 1,545 · see citing works
How does stress increase risk of drug abuse and relapse?
Sinha, R. (2001) · Psychopharmacology · doi:10.1007/s002130100917 · Cited by 1,505 · see citing works
Avena, N. M., Rada, P., & Hoebel, B. G. (2008) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2007.04.019 · Cited by 1,358 · see citing works
Drug addiction: updating actions to habits to compulsions ten years on
Everitt, B. J., & Robbins, T. W. (2016) · Annual Review of Psychology · doi:10.1146/annurev-psych-122414-033457 · Cited by 1,225 · see citing works
A translational profiling approach for the molecular characterization of CNS cell types
Heiman, M., Schaefer, A., Gong, S., Peterson, J. D., Day, M., Ramsey, K. E., Suárez-Fariñas, M., Schwarz, C., Stephan, D. A., Surmeier, D. J., et al. (2008) · Cell · doi:10.1016/j.cell.2008.10.028 · Cited by 1,134 · see citing works
Cocaine cues and dopamine in dorsal striatum: mechanism of craving in cocaine addiction
Volkow, N. D., Wang, G.-J., Telang, F., Fowler, J. S., Logan, J., Childress, A.-R., Jayne, M., Ma, Y., & Wong, C. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.1544-06.2006 · Cited by 1,164 · see citing works
Drug-evoked synaptic plasticity in addiction: from molecular changes to circuit remodeling
Lüscher, C., & Malenka, R. C. (2011) · Neuron · doi:10.1016/j.neuron.2011.01.017 · Cited by 1,105 · see citing works
Rogers, R. (1999) · Neuropsychopharmacology · doi:10.1016/s0893-133x(98)00091-8 · Cited by 1,101 · see citing works
Molecular mechanisms of drug addiction
Nestler, E. J. (2004) · Neuropharmacology · doi:10.1016/j.neuropharm.2004.06.031 · Cited by 1,108 · see citing works
Dopamine in drug abuse and addiction: results from imaging studies and treatment implications
Volkow, N. D., Fowler, J. S., Wang, G.-J., & Swanson, J. M. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001507 · Cited by 1,101 · see citing works
How can drug addiction help us understand obesity?
Volkow, N. D., & Wise, R. A. (2005) · Nature Neuroscience · doi:10.1038/nn1452 · Cited by 1,089 · see citing works
Effects of nicotine on the nucleus accumbens and similarity to those of addictive drugs.
Pontieri, F. E., Tanda, G., Orzi, F., & Chiara, G. D. (1996) · Nature · doi:10.1038/382255a0 · Cited by 1,073 · see citing works
Wise, R. A. (1996) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(96)80079-1 · Cited by 1,072 · see citing works
sagvolden, T., johansen, E. B., aase, H., & russell, V. A. (2005) · Behavioral and Brain Sciences · doi:10.1017/s0140525x05000075 · Cited by 1,035 · see citing works
Koob, G. F., Sanna, P. P., & Bloom, F. E. (1998) · Neuron · doi:10.1016/s0896-6273(00)80557-7 · Cited by 1,026 · see citing works
Reward Processing by the Opioid System in the Brain
Le Merrer, J., Becker, J. A. J., Befort, K., & Kieffer, B. L. (2009) · Physiological Reviews · doi:10.1152/physrev.00005.2009 · Cited by 1,013 · see citing works
Nucleus accumbens shell and core dopamine: differential role in behavior and addiction
Di Chiara, G. (2002) · Behavioural Brain Research · doi:10.1016/s0166-4328(02)00286-3 · Cited by 996 · see citing works
Imaging dopamine's role in drug abuse and addiction
Volkow, N. D., Fowler, J. S., Wang, G. J., Baler, R., & Telang, F. (2009) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.05.022 · Cited by 988 · see citing works
Computational roles for dopamine in behavioural control
Montague, P. R., Hyman, S. E., & Cohen, J. D. (2004) · Nature · doi:10.1038/nature03015 · Cited by 966 · see citing works
Dopamine and drug addiction: the nucleus accumbens shell connection
Di Chiara, G., Bassareo, V., Fenu, S., De Luca, M. A., Spina, L., Cadoni, C., Acquas, E., Carboni, E., Valentini, V., & Lecca, D. (2004) · Neuropharmacology · doi:10.1016/j.neuropharm.2004.06.032 · Cited by 935 · see citing works
Self-citationDecreased striatal dopaminergic responsiveness in detoxified cocaine-dependent subjects
Volkow, N. D., Wang, G.-J., Fowler, J. S., Logan, J., Gatley, S. J., Hitzemann, R., Chen, A. D., Dewey, S. L., & Pappas, N. (1997) · Nature · doi:10.1038/386830a0 · Cited by 854 · see citing works
The Neuroscience of Drug Reward and Addiction
Volkow, N. D., Michaelides, M., & Baler, R. (2019) · Physiological Reviews · doi:10.1152/physrev.00014.2018 · Cited by 863 · see citing works
The neuropsychological basis of addictive behaviour
Everitt, B. J., Dickinson, A., & Robbins, T. W. (2001) · Brain Research Reviews · doi:10.1016/s0165-0173(01)00088-1 · Cited by 808 · see citing works
Schizophrenia, dopamine and the striatum: From biology to symptoms
McCutcheon, R. A., Abi-Dargham, A., & Howes, O. D. (2019) · Trends in Neurosciences · doi:10.1016/j.tins.2018.12.004 · Cited by 763 · see citing works
Cigarette smoking: implications for psychiatric illness
(1993) · American Journal of Psychiatry · doi:10.1176/ajp.150.4.546 · Cited by 723 · see citing works
Long-term potentiation of excitatory inputs to brain reward areas by nicotine
Mansvelder, H. D., & McGehee, D. S. (2000) · Neuron · doi:10.1016/s0896-6273(00)00042-8 · Cited by 720 · see citing works
Amphetamine-induced dopamine release in human ventral striatum correlates with euphoria
Drevets, W. C., Gautier, C., Price, J. C., Kupfer, D. J., Kinahan, P. E., Grace, A. A., Price, J. L., & Mathis, C. A. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(00)01038-6 · Cited by 706 · see citing works
Psychomotor stimulant addiction: a neural systems perspective
Everitt, B. J., & Wolf, M. E. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-09-03312.2002 · Cited by 700 · see citing works
Synaptic mechanisms underlie nicotine-induced excitability of brain reward areas
Mansvelder, H. D., Keath, J. R., & McGehee, D. S. (2002) · Neuron · doi:10.1016/s0896-6273(02)00625-6 · Cited by 701 · see citing works
Solanto, M. V. (1998) · Behavioural Brain Research · doi:10.1016/s0166-4328(97)00175-7 · Cited by 677 · see citing works
Psychobiology of novelty seeking and drug seeking behavior
Bardo, M. T., Donohew, R. L., & Harrington, N. G. (1996) · Behavioural Brain Research · doi:10.1016/0166-4328(95)00203-0 · Cited by 667 · see citing works
Drug addiction: the neurobiology of disrupted self-control
Baler, R. D., & Volkow, N. D. (2006) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2006.10.005 · Cited by 640 · see citing works
Small, D. M., Jones-Gotman, M., & Dagher, A. (2003) · NeuroImage · doi:10.1016/s1053-8119(03)00253-2 · Cited by 632 · see citing works
Reward deficiency syndrome: genetic aspects of behavioral disorders
Comings, D. E., & Blum, K. (2000) · Progress in Brain Research · doi:10.1016/s0079-6123(00)26022-6 · Cited by 621 · see citing works
Intense Sweetness Surpasses Cocaine Reward
Lenoir, M., Serre, F., Cantin, L., & Ahmed, S. H. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000698 · Cited by 608 · see citing works
Hikida, T., Kimura, K., Wada, N., Funabiki, K., & Nakanishi, S. (2010) · Neuron · doi:10.1016/j.neuron.2010.05.011 · Cited by 592 · see citing works
Alcohol promotes dopamine release in the human nucleus accumbens
Boileau, I., Assaad, J., Pihl, R. O., Benkelfat, C., Leyton, M., Diksic, M., Tremblay, R. E., & Dagher, A. (2003) · Synapse · doi:10.1002/syn.10226 · Cited by 591 · see citing works
Addiction circuitry in the human brain
Volkow, N. D., Wang, G.-J., Fowler, J. S., & Tomasi, D. (2012) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010611-134625 · Cited by 592 · see citing works
McBride, W. J., Murphy, J. M., & Ikemoto, S. (1999) · Behavioural Brain Research · doi:10.1016/s0166-4328(99)00022-4 · Cited by 574 · see citing works
Biological substrates of reward and aversion: A nucleus accumbens activity hypothesis
Carlezon, W. A., & Thomas, M. J. (2009) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.06.075 · Cited by 561 · see citing works
Martinez, D., Slifstein, M., Broft, A., Mawlawi, O., Hwang, D.-R., Huang, Y., Cooper, T., Kegeles, L., Zarahn, E., Abi-Dargham, A., et al. (2003) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/01.wcb.0000048520.34839.1a · Cited by 569 · see citing works
Spanagel, R., Herz, A., & Shippenberg, T. S. (1990) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1990.tb04963.x · Cited by 539 · see citing works
Volkow, N. D., Wang, G., Fowler, J. S., Tomasi, D., Telang, F., & Baler, R. (2010) · BioEssays · doi:10.1002/bies.201000042 · Cited by 532 · see citing works
Sagvolden, T. (2000) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(99)00058-5 · Cited by 525 · see citing works
Belin, D., Jonkman, S., Dickinson, A., Robbins, T. W., & Everitt, B. J. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.09.027 · Cited by 520 · see citing works
Pliakas, A. M., Carlson, R. R., Neve, R. L., Konradi, C., Nestler, E. J., & Carlezon, W. A. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-18-07397.2001 · Cited by 509 · see citing works
The nucleus accumbens: a comprehensive review
Salgado, S., & Kaplitt, M. G. (2015) · Stereotactic and Functional Neurosurgery · doi:10.1159/000368279 · Cited by 489 · see citing works
Differential control over cocaine-seeking behavior by nucleus accumbens core and shell
Ito, R., Robbins, T. W., & Everitt, B. J. (2004) · Nature Neuroscience · doi:10.1038/nn1217 · Cited by 501 · see citing works
Initiation and adaptation: a paradigm for understanding psychotropic drug action
(1996) · American Journal of Psychiatry · doi:10.1176/ajp.153.2.151 · Cited by 490 · see citing works
Antidepressant-Like Effects of κ-Opioid Receptor Antagonists in the Forced Swim Test in Rats
Mague, S. D., Pliakas, A. M., Todtenkopf, M. S., Tomasiewicz, H. C., Zhang, Y., Stevens, W. C., Jones, R. M., Portoghese, P. S., & Carlezon, W. A. (2003) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.046433 · Cited by 485 · see citing works
Variables That Affect the Clinical Use and Abuse of Methylphenidate in the Treatment of ADHD
Volkow, N. D., & Swanson, J. M. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.11.1909 · Cited by 475 · see citing works
Leyton, M. (2002) · Neuropsychopharmacology · doi:10.1016/s0893-133x(02)00366-4 · Cited by 476 · see citing works
Compulsive drug use linked to sensitized ventral striatal dopamine transmission.
Evans, A. H., Pavese, N., Lawrence, A. D., Tai, Y. F., Appel, S., Doder, M., Brooks, D. J., Lees, A. J., & Piccini, P. (2006) · Annals of Neurology · doi:10.1002/ana.20822 · Cited by 473 · see citing works
Ito, R., Dalley, J. W., Robbins, T. W., & Everitt, B. J. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-14-06247.2002 · Cited by 463 · see citing works
Brain reward circuitry beyond the mesolimbic dopamine system: a neurobiological theory
Ikemoto, S. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.02.001 · Cited by 454 · see citing works
REVIEW: Acute withdrawal, protracted abstinence and negative affect in alcoholism: are they linked?
Heilig, M., Egli, M., Crabbe, J. C., & Becker, H. C. (2010) · Addiction Biology · doi:10.1111/j.1369-1600.2009.00194.x · Cited by 435 · see citing works
The D <sub>2</sub> Dopamine Receptor Gene as a Determinant of Reward Deficiency Syndrome
Blum, K., Sheridan, P. J., Wood, R. C., Braverman, E. R., Chen, T. J. H., phd, J. G. C., & Comings, D. E. (1996) · Journal of the Royal Society of Medicine · doi:10.1177/014107689608900711 · Cited by 443 · see citing works
Amphetamine Exposure Enhances Habit Formation
Nelson, A., & Killcross, S. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.4305-05.2006 · Cited by 445 · see citing works
Historical review: molecular and cellular mechanisms of opiate and cocaine addiction
Nestler, E. J. (2004) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2004.02.005 · Cited by 425 · see citing works
Benwell, M. E. M., & Balfour, D. J. K. (1992) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1992.tb09067.x · Cited by 426 · see citing works
The neurocircuitry of addiction: an overview
Feltenstein, M. W., & See, R. E. (2008) · British Journal of Pharmacology · doi:10.1038/bjp.2008.51 · Cited by 421 · see citing works
Nieh, E. H., Vander Weele, C. M., Matthews, G. A., Presbrey, K. N., Wichmann, R., Leppla, C. A., Izadmehr, E. M., & Tye, K. M. (2016) · Neuron · doi:10.1016/j.neuron.2016.04.035 · Cited by 387 · see citing works
Volkow, N. D., Wang, G.-J., Fowler, J. S., Hitzemann, R., Angrist, B., Gatley, S. J., Logan, J., Ding, Y.-S., & Pappas, N. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.1.19 · Cited by 405 · see citing works
Ersche, K. D., Barnes, A., Jones, P. S., Morein-Zamir, S., Robbins, T. W., & Bullmore, E. T. (2011) · Brain · doi:10.1093/brain/awr138 · Cited by 389 · see citing works
Role of dopamine in drug reinforcement and addiction in humans: results from imaging studies
Volkow, N. D., Fowler, J. S., & Wang, G.-J. (2002) · Behavioural Pharmacology · doi:10.1097/00008877-200209000-00008 · Cited by 398 · see citing works
Pharmacological evidence for a motivational role of κ-opioid systems in ethanol dependence
Walker, B. M., & Koob, G. F. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301438 · Cited by 392 · see citing works
Funk, C. K., O'Dell, L. E., Crawford, E. F., & Koob, G. F. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.3096-06.2006 · Cited by 381 · see citing works
Carlezon, W. A., Béguin, C., DiNieri, J. A., Baumann, M. H., Richards, M. R., Todtenkopf, M. S., Rothman, R. B., Ma, Z., Lee, D. Y.-W., & Cohen, B. M. (2006) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.105.092304 · Cited by 390 · see citing works
Pharmacogenetics and Human Molecular Genetics of Opiate and Cocaine Addictions and Their Treatments
Kreek, M. J., Bart, G., Lilly, C., Laforge, K. S., & Nielsen, D. A. (2005) · Pharmacological Reviews · doi:10.1124/pr.57.1.1 · Cited by 391 · see citing works
Dynorphin and the pathophysiology of drug addiction
Shippenberg, T. S., Zapata, A., & Chefer, V. I. (2007) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2007.06.011 · Cited by 387 · see citing works
Sulzer, D., & Rayport, S. (1990) · Neuron · doi:10.1016/0896-6273(90)90339-h · Cited by 389 · see citing works
Imaging endogenous dopamine competition with [<sup>11</sup>C]raclopride in the human brain
Volkow, N. D., Wang, G., Fowler, J. S., Logan, J., Schlyer, D., Hitzemann, R., Lieberman, J., Angrist, B., Pappas, N., MacGregor, R., et al. (1994) · Synapse · doi:10.1002/syn.890160402 · Cited by 379 · see citing works
Phasic Dopamine Release Evoked by Abused Substances Requires Cannabinoid Receptor Activation
Cheer, J. F., Wassum, K. M., Sombers, L. A., Heien, M. L. A. V., Ariansen, J. L., Aragona, B. J., Phillips, P. E. M., & Wightman, R. M. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.4152-06.2007 · Cited by 374 · see citing works
Cigarette Smoking Saturates Brain α4β2 Nicotinic Acetylcholine Receptors
Brody, A. L., Mandelkern, M. A., London, E. D., Olmstead, R. E., Farahi, J., Scheibal, D., Jou, J., Allen, V., Tiongson, E., Chefer, S. I., et al. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.8.907 · Cited by 367 · see citing works
Increased nicotinic receptors in brains from smokers: membrane binding and autoradiography studies
Perry, D. C., Dávila-Garcı́a, M. I., Stockmeier, C. A., & Kellar, K. J. (1999) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)38304-1 · Cited by 362 · see citing works
Dopaminergic dynamics underlying sex-specific cocaine reward
Calipari, E. S., Juarez, B., Morel, C., Walker, D. M., Cahill, M. E., Ribeiro, E., Roman-Ortiz, C., Ramakrishnan, C., Deisseroth, K., Han, M.-H., et al. (2017) · Nature Communications · doi:10.1038/ncomms13877 · Cited by 359 · see citing works
One Is Not Enough: Understanding and Modeling Polysubstance Use
Crummy, E. A., O’Neal, T. J., Baskin, B. M., & Ferguson, S. M. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00569 · Cited by 351 · see citing works
Cannabinoids Enhance Subsecond Dopamine Release in the Nucleus Accumbens of Awake Rats
Cheer, J. F., Wassum, K. M., Heien, M. L. A. V., Phillips, P. E. M., & Wightman, R. M. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.0529-04.2004 · Cited by 343 · see citing works
Alcohol dependence as a chronic pain disorder
Egli, M., Koob, G. F., & Edwards, S. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.07.010 · Cited by 347 · see citing works
Morphine reward in dopamine-deficient mice
Hnasko, T. S., Sotak, B. N., & Palmiter, R. D. (2005) · Nature · doi:10.1038/nature04172 · Cited by 338 · see citing works
Caffeine Induces Dopamine and Glutamate Release in the Shell of the Nucleus Accumbens
Solinas, M., Ferré, S., You, Z.-B., Karcz-Kubicha, M., Popoli, P., & Goldberg, S. R. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-15-06321.2002 · Cited by 338 · see citing works
Veilleux, J. C., Colvin, P. J., Anderson, J., York, C., & Heinz, A. J. (2010) · Clinical Psychology Review · doi:10.1016/j.cpr.2009.10.006 · Cited by 336 · see citing works
Rewarding Actions of Phencyclidine and Related Drugs in Nucleus Accumbens Shell and Frontal Cortex
Carlezon, & Wise, R. A. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-09-03112.1996 · Cited by 327 · see citing works
Everitt, B. J. (2014) · European Journal of Neuroscience · doi:10.1111/ejn.12644 · Cited by 318 · see citing works
Burkett, J. P., & Young, L. J. (2012) · Psychopharmacology · doi:10.1007/s00213-012-2794-x · Cited by 307 · see citing works
“All known drugs of abuse cause DA release in the nucleus accumbens ( NAC ) , preferentially in the nucleus accumbens shell ( NACs ) region , and also more broadly throughout the mesolimbic DA pathway ( Swanson 1982 ; Di Chiara and Imperato 1988 ; Koob and Bloom 1988 ; Pontieri et al .”
Dichter, G. S., Damiano, C. A., & Allen, J. A. (2012) · Journal of Neurodevelopmental Disorders · doi:10.1186/1866-1955-4-19 · Cited by 299 · see citing works
Cohen, J. D. (2005) · Journal of Economic Perspectives · doi:10.1257/089533005775196750 · Cited by 304 · see citing works
Volkow, N. D., Wang, G.-J., Ma, Y., Fowler, J. S., Zhu, W., Maynard, L., Telang, F., Vaska, P., Ding, Y.-S., Wong, C., et al. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-36-11461.2003 · Cited by 302 · see citing works
Marijuana and cannabinoid regulation of brain reward circuits
Lupica, C. R., Riegel, A. C., & Hoffman, A. F. (2004) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705931 · Cited by 289 · see citing works
Pothos, E., Rada, P., Mark, G. P., & Hoebel, B. G. (1991) · Brain Research · doi:10.1016/0006-8993(91)91724-f · Cited by 288 · see citing works
- Authors
- Di Chiara, G., & Imperato, A.
- Affiliations
- Institute of Experimental Pharmacology and Toxicology, University of Cagliari, Italy.
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 1988-07
- Volume
- 85
- Issue
- 14
- Pages
- 5274-5278
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC281732
- OpenAlex
- W2165398609
- Cited by
- 4,733
- References
- 27
- Citations by year
- 2026: 62 · 2025: 104 · 2024: 78 · 2023: 112 · 2022: 141 · 2021: 133 · 2020: 160 · 2019: 155 · 2018: 162 · 2017: 141 · 2016: 183 · 2015: 173 · 2014: 194 · 2013: 193 · 2012: 163
- FWCI
- 12.96
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- UNICA IRIS Institutional Research Information System (University of Cagliari) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- drug abuse, extracellular dopamine, mesolimbic system, nucleus accumbens septi, dopamine release, hypermotility, hypomotility, kappa opioid receptor agonists, U50,488, tifluadom, bremazocine, haloperidol, imipramine, atropine, diphenhydramine, opiates, ethanol, nicotine, amphetamine, cocaine, limbic system
- MeSH terms
- Ethanol, Amphetamine, Animals, Caudate Nucleus, Cocaine, Dopamine, Homovanillic Acid, Kinetics, Male, Narcotics, Nicotine, Nucleus Accumbens, Rats, Inbred Strains, Receptors, Opioid, Septal Nuclei, Illicit Drugs, Synapses, Antipsychotic Agents, 3,4-Dihydroxyphenylacetic Acid, Receptors, Opioid, mu, Receptors, Opioid, kappa, Rats
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