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Predictors of and Satisfaction with Bilateral Prophylactic Mastectomy
Open accessAbstract
BACKGROUND: Women with a first-degree relative with breast cancer are at increased risk of developing this disease. The optimal medical management of these women is unclear, with options including close breast cancer screening, bilateral prophylactic mastectomy, or participation in chemoprevention trials. Among women who undergo prophylactic bilateral mastectomy, very little is known about satisfaction with this surgery. Also, we know very little about variables related to prophylactic mastectomy decision making. METHODS: Participants were women at increased risk of breast cancer due to family history. These women were categorized by self-report as not interested in prophylactic mastectomy (n = 58), interested but deciding against surgery (n = 92), or subsequently having a bilateral prophylactic mastectomy (n = 14). Information on screening practices, risk perception, level of depression, and cancer-related worry was collected. Women completing prophylactic mastectomy reported on their satisfaction with the surgery and breast reconstruction. RESULTS: Women selecting surgery reported more breast cancer worry. The group expressing no interest in surgery reported fewer biopsies and lower risk estimates. Women completing surgery were satisfied with their decision, although satisfaction with reconstruction was mixed. CONCLUSION: Factors influencing surgical decision making may include breast-cancer-related worry, biopsy history, and subjective breast cancer risk.
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“Women who elected to undergo PM reported experiencing higher levels of anxiety associated with developing breast cancer than those women who did not opt for surgery [7].”
From Standard psychological consultations and follow up for women at increased risk of hereditary breast cancer considering prophylactic mastectomy (2009) · cites this paper as [7]
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Efficacy of Bilateral Prophylactic Mastectomy in Women with a Family History of Breast Cancer
Hartmann, L. C., Schaid, D. J., Woods, J. E., Crotty, T. P., Myers, J. L., Arnold, P. G., Petty, P. M., Sellers, T. A., Johnson, J. L., McDonnell, S. K., et al. (1999) · New England Journal of Medicine · doi:10.1056/nejm199901143400201 · Cited by 1,428
Breast Cancer after Prophylactic Bilateral Mastectomy in Women with a BRCA1 or BRCA2 Mutation
Meijers-Heijboer, H., van Geel, B., van Putten, W. L. J., Henzen-Logmans, S. C., Seynaeve, C., Menke-Pluymers, M. B. E., Bartels, C. C. M., Verhoog, L. C., van den Ouweland, A. M. W., Niermeijer, M. F., et al. (2001) · New England Journal of Medicine · doi:10.1056/nejm200107193450301 · Cited by 973
Katapodi, M. C., Lee, K. A., Facione, N. C., & Dodd, M. J. (2004) · Preventive Medicine · doi:10.1016/j.ypmed.2003.11.012 · Cited by 476
“37) and were also more likely to undergo prophylactic mastectomy as a means for breast cancer prevention [45,46] (total N = 307, g = 0.”
BackgroundRisk Assessment, Genetic Counseling, and Genetic Testing for BRCA -Related Cancer
US Preventive Services Task Force, Owens, D. K., Davidson, K. W., Krist, A. H., Barry, M. J., Cabana, M. D., Caughey, A. B., Doubeni, C. A., Epling, J. W., Kubik, M., et al. (2019) · JAMA · doi:10.1001/jama.2019.10987 · Cited by 487
Prophylactic mastectomy for the prevention of breast cancer
Lostumbo, L., Carbine, N. E., & Wallace, J. (2010) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002748.pub3 · Cited by 402
Metadata
- Authors
- Stefanek, M. E., Helzlsouer, K. J., Wilcox, P. M., & Houn, F.
- Affiliations
- United States Food and Drug Administration (US)
- ORCID
- Helzlsouer, K.J.
- Venue
- Preventive Medicine
- Publisher
- Elsevier BV
- Published
- 1995-07
- Volume
- 24
- Issue
- 4
- Pages
- 412-419
- ISSN
- 0091-7435 (ISSN-L)
- OpenAlex
- W2044170626
- Cited by
- 177
- References
- 0
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 1 · 2022: 2 · 2021: 1 · 2019: 2 · 2018: 2 · 2017: 2 · 2016: 2 · 2015: 1 · 2014: 3 · 2013: 2 · 2012: 4
- FWCI
- 2.08
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Preventive Medicine (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › BRCA gene mutations in cancer
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Women's cancer prevention and management
- Health Sciences › Medicine › Surgery › Breast Implant and Reconstruction
- Keywords
- bilateral prophylactic mastectomy, breast cancer risk, family history of breast cancer, patient satisfaction, surgical decision-making, breast cancer worry, risk perception, breast cancer screening, breast reconstruction, depression, chemoprevention
- MeSH terms
- Adult, Analysis of Variance, Biopsy, Breast Neoplasms, Decision Making, Disease Susceptibility, Family Health, Female, Humans, Life Change Events, Mastectomy, Middle Aged, Stress, Psychological, Chi-Square Distribution, Mammaplasty, Patient Satisfaction, Patient Selection
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