The role of / T cells in the feto-maternal relationship
Abstract
Polymorphic MHC is absent from the trophoblast, therefore, it resists NK as well as CTL-mediated lysis in vitro. Activated gamma / delta TCR positive cells are significantly enriched in the decidua as well as in peripheral blood of healthy pregnant women. Human peripheral gamma / delta lymphocytes preferentially express the V gamma 9/V delta 2 TCR, whereas those of the decidua use the V delta 1 chain. These subpopulations are functionally polarized, the former being Th1, the latter Th2. Potentially cytotoxic V delta 2+ lymphocytes recognize HLA-E on the trophoblast via the CD94/NKG2A receptor, which induces an inhibitory signal, thus potentially inhibiting Th1 type cytokine production.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The majority of γδ T cells in the uterus were memory cells with higher expression of CD44 and CD27 but lower expression of CD62L and CCR7 compared to those in the blood.
“Further studies indicated that the majority of γδ T cells in the uterus were memory cells with higher expression of CD44 and CD27 but lower expression of CD62L and CCR7 compared to those in the blood (48).”
From Comparing Mouse and Human Tissue-Resident γδ T Cells (2022) · cites this paper as [48]
The ratio of activated γδ TCR+ cells was significantly increased in normal pregnancies compared to that of recurrent abortions.
“The ratio of activated γδ TCR+ cells was significantly increased in normal pregnancies compared to that of recurrent abortions (48).”
From Comparing Mouse and Human Tissue-Resident γδ T Cells (2022) · cites this paper as [48]
The percentages of γδ T cells were significantly higher in the uterus than in peripheral blood, and most γδ T cells in mouse uterus were distributed in the endometrium.
“A recent study has reported that the percentages of γδ T cells were significantly higher in the uterus than in peripheral blood, and most γδ T cells in mouse uterus were distributed in the endometrium (48).”
From Comparing Mouse and Human Tissue-Resident γδ T Cells (2022) · cites this paper as [48]
Cited by
Sorted by citations
Comparing Mouse and Human Tissue-Resident γδ T Cells
Qu, G., Wang, S., Zhou, Z., Jiang, D., Liao, A., & Luo, J. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.891687 · Cited by 87 · see citing works
“Further studies indicated that the majority of gd T cells in the uterus were memory cells with higher expression of CD44 and CD27 but lower expression of CD62L and CCR7 compared to those in the blood (48).”
BackgroundInfluentialPregnancy and gamma/delta T cells: Taking on the hard questions
Mincheva-Nilsson, L. (2003) · Reproductive Biology and Endocrinology · doi:10.1186/1477-7827-1-120 · Cited by 79 · see citing works
- Authors
- Szekeres-Bartho, J., Barakonyi, A., Miko, E., Polgar, B., & Palkovics, T.
- Affiliations
- University of Pecs (HU)
- Venue
- Seminars in Immunology
- Publisher
- Elsevier BV
- Published
- 2001-08
- Volume
- 13
- Issue
- 4
- Pages
- 229-233
- ISSN
- 1044-5323 (ISSN-L)
- OpenAlex
- W1994846101
- Cited by
- 85
- References
- 0
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 3 · 2023: 2 · 2022: 7 · 2021: 4 · 2020: 4 · 2019: 3 · 2017: 3 · 2016: 2 · 2015: 5 · 2014: 1 · 2013: 2 · 2012: 5
- FWCI
- 0.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Seminars in Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Fonds National de la Recherche Luxembourg
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Life Sciences › Immunology and Microbiology › Immunology › Immune Cell Function and Interaction
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Pregnancy-related medical research
- Keywords
- γδ T cells, decidua, trophoblast, MHC polymorphism, natural killer cells, cytotoxic T lymphocytes, Th1/Th2 polarization, HLA-E, CD94/NKG2A, pregnancy immunology
- MeSH terms
- Decidua, Female, HLA Antigens, Humans, Maternal-Fetal Exchange, Pregnancy, Trophoblasts, T-Lymphocyte Subsets, Receptors, Antigen, T-Cell, gamma-delta, Antigen Presentation, In Vitro Techniques
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
