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Cited by 79Reproductive System and PregnancyT-cell and B-cell ImmunologyPregnancy-related medical research

Pregnancy and gamma/delta T cells: Taking on the hard questions

Open access
Mincheva-Nilsson, Lucia·2003·Reproductive Biology and Endocrinology
DOI 10.1186/1477-7827-1-120PMC PMC305336
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Abstract

Considering the allograft rejection as one of the basic features of the immune system, the mammalian pregnancy is still a puzzling situation where the semiallogeneic embryo, a mating product of non-histocompatible individuals is not rejected. How are the demands of pregnancy solved in the context of the maternal immunity? How is the competent maternal immune system modulated during pregnancy? These are hard questions to answer and an intriguing challenge for immunologists to explain. Historically, the mammalian fetus has been regarded as a successful allograft, a tumor or a parasite [ 1 , 2 ]. Although the mechanisms that promote the survival of the conceptus are at large still unknown, it has become increasingly clear that the maternal immune tolerance towards the fetus is the result of the interactions of a jigsaw puzzle of actors – cells, serum proteins, hormones, cytokines, enzymes and neurotransmitters.

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  • Mouse Vγ6/Vδ1 cells are closely associated with the epithelial tissue of the female reproductive tract and account for a major proportion of γδ T cells in uterine tissue.

    “Mouse Vγ6/Vδ1 cells are closely associated with the epithelial tissue of the female reproductive tract and account for a major proportion of γδ T cells in uterine tissue (47).”

    From Comparing Mouse and Human Tissue-Resident γδ T Cells (2022) · cites this paper as [47]

    In “γδT cells at the feto-maternal interface” (page unavailable), the paper says Vδ1 is preferentially used by γδ T cells in normal and pregnant mouse uteri. The “Vδ usage” section (page unavailable) places resident γδ T cells at uterine and vaginal epithelial surfaces. The copy does not identify those cells as Vγ6/Vδ1 or establish that this specific subset accounts for a major proportion of uterine γδ T cells. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

  • In healthy pregnant women, there was an accumulation of Vδ1+ circulating cells, in contrast to women with recurrent abortions where the Vδ2+ circulating cells dominated.

    “In healthy pregnant women, there was an accumulation of Vδ1+ circulating cells, in contrast to women with recurrent abortions where the Vδ2+ circulating cells dominated (47).”

    From Comparing Mouse and Human Tissue-Resident γδ T Cells (2022) · cites this paper as [47]

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Authors
Mincheva-Nilsson, L.
Venue
Reproductive Biology and Endocrinology
Publisher
Springer Science and Business Media LLC
Published
2003-12-02
Volume
1
Issue
1
Pages
120-120
ISSN
1477-7827 (ISSN-L)
DOI
10.1186/1477-7827-1-120
PMC
PMC305336
OpenAlex
W2115797193
Cited by
79
References
65
Citations by year
2026: 2 · 2025: 5 · 2024: 5 · 2023: 5 · 2022: 8 · 2021: 5 · 2020: 1 · 2019: 3 · 2018: 8 · 2017: 4 · 2016: 3 · 2015: 4 · 2014: 2 · 2013: 3 · 2012: 2
FWCI
0.17
Type
journal article
Language
en
Open access
Locations
  • Reproductive Biology and Endocrinology (publishedVersion)
  • PubMed Central (publishedVersion, other-oa)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
  • Cancerfonden
  • Umeå Universitet
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Pregnancy-related medical research
Keywords
pregnancy, γδ T cells, maternal-fetal immune tolerance, allograft rejection, cytokines, hormones, neurotransmitters, serum proteins
MeSH terms
Decidua, Female, Humans, Lymphoid Tissue, Maternal-Fetal Exchange, Pregnancy, T-Lymphocytes, Receptors, Antigen, T-Cell, gamma-delta

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