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Suppression of Apoptotic Cell Death by Hepatitis C Virus Core Protein
Open accessAbstract
We have previously demonstrated the role of hepatitis C virus (HCV) core protein in the transcriptional regulation of cellular and unrelated viral promoters. Furthermore, the core protein in cooperation with H-ras oncogene transforms primary rat embryo fibroblast cells to the tumorigenic phenotype. In the present study, the functional role of HCV core protein was investigated to determine its potential to inhibit the onset of apoptotic cell death. Expression of HCV core protein inhibited cisplatin mediated apoptosis in human cervical epithelial cells, and apoptosis induced by the overexpression of c-myc in Chinese hamster ovarian cells. Results from these studies suggest that the core protein may have a biological implication in the pathogenesis of HCV infection.
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Cited by
The core protein of hepatitis C virus induces hepatocellular carcinoma in transgenic mice
Moriya, K., Fujie, H., Shintani, Y., Yotsuyanagi, H., Tsutsumi, T., Ishibashi, K., Matsuura, Y., Kimura, S., Miyamura, T., & Koike, K. (1998) · Nature Medicine · doi:10.1038/2053 · Cited by 1,206
Okuda, M., Li, K., Beard, M. R., Showalter, L. A., Scholle, F., Lemon, S. M., & Weinman, S. A. (2002) · Gastroenterology · doi:10.1053/gast.2002.30983 · Cited by 926
Hassan, M. M., Hwang, L.-Y., Hatten, C. J., Swaim, M., Li, D., Abbruzzese, J. L., Beasley, P., & Patt, Y. Z. (2002) · Hepatology · doi:10.1053/jhep.2002.36780 · Cited by 762
Infections as a major preventable cause of human cancer
Kuper, H., Adami, H. ‐., & Trichopoulos, D. (2000) · Journal of Internal Medicine · doi:10.1046/j.1365-2796.2000.00742.x · Cited by 740
Metadata
- Authors
- Ray, R. B., Meyer, K., & Ray, R.
- Venue
- Virology
- Publisher
- Elsevier BV
- Published
- 1996-12
- Volume
- 226
- Issue
- 2
- Pages
- 176-182
- ISSN
- 0042-6822 (ISSN-L)
- OpenAlex
- W1977779856
- Cited by
- 265
- References
- 0
- FWCI
- 9.29
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Ray, R. B., Meyer, K., & Ray, R. (1996). Suppression of Apoptotic Cell Death by Hepatitis C Virus Core Protein. Virology. https://doi.org/10.1006/viro.1996.0644
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