HIF-1 is Essential for Multilineage Hematopoiesis in the Embryo
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Redox-modulated HIF regulation operates in intact organisms, not only in cell culture.
“Importantly, redox-modulated HIF regulation operates in intact organisms, not only in cell culture.”
From HIF inhibition: Current strategies and clinical challenges (2026) · cites this paper as [211]
HIF signaling is indispensable for embryonic oxygen adaptation and vascular development.
“while developmental analyses by Adelman, Maltepe, Simon, and co-workers established that HIF signaling is indispensable for embryonic oxygen adaptation and vascular development [[211], [212], [213]].”
From HIF inhibition: Current strategies and clinical challenges (2026) · cites this paper as [211]
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“…redox-sensitive regulation of erythropoietin production and HIF activity in physiological settings [210], while developmental analyses by Adelman, Maltepe, Simon, and co-workers established that HIF signaling is indispensable for embryonic oxygen adaptation and vascular development [211 – 213].”
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- Authors
- Adelman, D. M., Maltepe, E., & Simon, M. C.
- Affiliations
- University of Chicago (US)
- Howard Hughes Medical Institute (US)
- Venue
- Advances in Experimental Medicine and Biology
- Publisher
- Springer US
- Published
- 2002
- Volume
- 475
- Pages
- 275-284
- ISSN
- 0065-2598 (ISSN-L)
- OpenAlex
- W2227986439
- Cited by
- 25
- References
- 26
- Citations by year
- 2026: 1 · 2020: 1 · 2013: 3 · 2012: 3
- FWCI
- 5.01
- Type
- book chapter
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Advances in experimental medicine and biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Howard Hughes Medical Institute
- Topics
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Health Sciences › Medicine › Hematology › Erythropoietin and Anemia Treatment
- Keywords
- HIF-1, hypoxia-inducible factor, multilineage hematopoiesis, embryonic hematopoiesis, oxygen sensing, embryonic development
- MeSH terms
- Animals, Chimera, Colony-Forming Units Assay, DNA-Binding Proteins, Female, Fetal Hypoxia, Embryonic and Fetal Development, Hematopoiesis, Lymphokines, Mice, Inbred C57BL, Models, Biological, Nuclear Proteins, Pregnancy, Transcription Factors, Yolk Sac, Cell Hypoxia, Cytokines, Endothelial Growth Factors, Receptors, Aryl Hydrocarbon, Mice, Knockout, Vascular Endothelial Growth Factors, Vascular Endothelial Growth Factor A, Mice, Aryl Hydrocarbon Receptor Nuclear Translocator, Hypoxia-Inducible Factor 1, Hypoxia-Inducible Factor 1, alpha Subunit, In Vitro Techniques
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