Cited by 25Hematopoietic Stem Cell TransplantationCancer, Hypoxia, and MetabolismErythropoietin and Anemia Treatment

HIF-1 is Essential for Multilineage Hematopoiesis in the Embryo

Adelman, David M., Maltepe, Emin, Simon, M. Celeste·2002·Advances in Experimental Medicine and Biology

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Registry

Crossref · 10.1007/0-306-46825-5_26

Cites

26 of 26 references verified0 citation errors · 0 not checkable

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  • Redox-modulated HIF regulation operates in intact organisms, not only in cell culture.

    “Importantly, redox-modulated HIF regulation operates in intact organisms, not only in cell culture.”

    From HIF inhibition: Current strategies and clinical challenges (2026) · cites this paper as [211]

  • HIF signaling is indispensable for embryonic oxygen adaptation and vascular development.

    “while developmental analyses by Adelman, Maltepe, Simon, and co-workers established that HIF signaling is indispensable for embryonic oxygen adaptation and vascular development [[211], [212], [213]].”

    From HIF inhibition: Current strategies and clinical challenges (2026) · cites this paper as [211]

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Authors
Adelman, D. M., Maltepe, E., & Simon, M. C.
Affiliations
  • University of Chicago (US)
  • Howard Hughes Medical Institute (US)
Venue
Advances in Experimental Medicine and Biology
Publisher
Springer US
Published
2002
Volume
475
Pages
275-284
ISSN
0065-2598 (ISSN-L)
OpenAlex
W2227986439
Cited by
25
References
26
Citations by year
2026: 1 · 2020: 1 · 2013: 3 · 2012: 3
FWCI
5.01
Type
book chapter
Language
en
Open access
closed
Locations
  • Advances in experimental medicine and biology (publishedVersion)
  • PubMed (publishedVersion)
Funders
Howard Hughes Medical Institute
Topics
  • Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
  • Health Sciences › Medicine › Hematology › Erythropoietin and Anemia Treatment
Keywords
HIF-1, hypoxia-inducible factor, multilineage hematopoiesis, embryonic hematopoiesis, oxygen sensing, embryonic development
MeSH terms
Animals, Chimera, Colony-Forming Units Assay, DNA-Binding Proteins, Female, Fetal Hypoxia, Embryonic and Fetal Development, Hematopoiesis, Lymphokines, Mice, Inbred C57BL, Models, Biological, Nuclear Proteins, Pregnancy, Transcription Factors, Yolk Sac, Cell Hypoxia, Cytokines, Endothelial Growth Factors, Receptors, Aryl Hydrocarbon, Mice, Knockout, Vascular Endothelial Growth Factors, Vascular Endothelial Growth Factor A, Mice, Aryl Hydrocarbon Receptor Nuclear Translocator, Hypoxia-Inducible Factor 1, Hypoxia-Inducible Factor 1, alpha Subunit, In Vitro Techniques

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