The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
PI3K/PTEN/Akt Pathway
Abstract
In conclusion, direct genetic alterations leading to deregulated PI3K/Akt signalling are common in a significant fraction of human malignancies. The forthcoming decade should witness the development and clinical deployment of a number of novel small molecule inhibitors specifically designed to disrupt the function of members of this pathway. It is hoped and perhaps likely that such inhibitors, either alone or in combination with current therapeutics, will ultimately proof clinically efficacious.
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Li, J., Yen, C., Liaw, D., Podsypanina, K., Bose, S., Wang, S. I., Puc, J., Miliaresis, C., Rodgers, L., McCombie, R., et al. (1997) · Science · doi:10.1126/science.275.5308.1943 · Cited by 4,785
Cellular survival: a play in three Akts
Datta, S. R., Brunet, A., & Greenberg, M. E. (1999) · Genes & Development · doi:10.1101/gad.13.22.2905 · Cited by 4,216
Regulation of translation initiation by FRAP/mTOR
Gingras, A.-C., Raught, B., & Sonenberg, N. (2001) · Genes & Development · doi:10.1101/gad.887201 · Cited by 1,545
A motif-based profile scanning approach for genome-wide prediction of signaling pathways
Yaffe, M. B., Leparc, G. G., Lai, J., Obata, T., Volinia, S., & Cantley, L. C. (2001) · Nature Biotechnology · doi:10.1038/86737 · Cited by 517
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Pathogenesis of Liver Fibrosis
Hernandez-Gea, V., & Friedman, S. L. (2011) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-011110-130246 · Cited by 1,809
Ionizing Radiation-Induced DNA Damage, Response, and Repair
Santivasi, W. L., & Xia, F. (2014) · Antioxidants & Redox Signaling · doi:10.1089/ars.2013.5668 · Cited by 593
WWP2 is an E3 ubiquitin ligase for PTEN
Maddika, S., Kavela, S., Rani, N., Palicharla, V. R., Pokorny, J. L., Sarkaria, J. N., & Chen, J. (2011) · Nature Cell Biology · doi:10.1038/ncb2240 · Cited by 305
Boxus, M., Twizere, J.-C., Legros, S., Dewulf, J.-F., Kettmann, R., & Willems, L. (2008) · Retrovirology · doi:10.1186/1742-4690-5-76 · Cited by 255
Gao, H., Ouyang, X., Banach-Petrosky, W. A., Gerald, W. L., Shen, M. M., & Abate-Shen, C. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0606836103 · Cited by 141
Metadata
- Authors
- Paez, J., & Sellers, W. R.
- Venue
- Cancer Treatment and Research
- Publisher
- Kluwer Academic Publishers
- Published
- 2006-02-27
- Pages
- 145-167
- OpenAlex
- W145441032
- Cited by
- 180
- References
- 4
- FWCI
- 27.45
- Type
- book chapter
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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