The DOI matches its Crossref record; 103 of the 103 references it cites were found in a registry or an index.
Distribution of Cannabinoid Receptors in the Central and Peripheral Nervous System
Abstract
CB1 cannabinoid receptors appear to mediate most, if not all of the psychoactive effects of delta-9-tetrahydrocannabinol and related compounds. This G protein-coupled receptor has a characteristic distribution in the nervous system: It is particularly enriched in cortex, hippocampus, amygdala, basal ganglia outflow tracts, and cerebellum--a distribution that corresponds to the most prominent behavioral effects of cannabis. In addition, this distribution helps to predict neurological and psychological maladies for which manipulation of the endocannabinoid system might be beneficial. CB1 receptors are primarily expressed on neurons, where most of the receptors are found on axons and synaptic terminals, emphasizing the important role of this receptor in modulating neurotransmission at specific synapses. While our knowledge of CB1 localization in the nervous system has advanced tremendously over the past 15 years, there is still more to learn. Particularly pressing is the need for (1) detailed anatomical studies of brain regions important in the therapeutic actions of drugs that modify the endocannabinoid system and (2) the determination of the localization of the enzymes that synthesize, degrade, and transport the endocannabinoids.
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“CB1R is the most densely expressed in the brain and is present at high levels in corticolimbic regions mediating anxiety, including the medial prefrontal cortex (mPFC) and hippocampus, as well as the BLA [11,14]”
From Amygdala FAAH and anandamide: mediating protection and recovery from stress (2013) · cites this paper as [14]
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Cites
Structure of a cannabinoid receptor and functional expression of the cloned cDNA
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Immunohistochemical distribution of cannabinoid CB1 receptors in the rat central nervous system
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Self-citationBrain monoglyceride lipase participating in endocannabinoid inactivation
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Self-citationCB1 Cannabinoid Receptors and On-Demand Defense Against Excitotoxicity
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Research works printed but not linked: 1
- Riegal AC, Williams JT, Lupica CR (2003) Cananbionid CB1 receptors inhibit GABA-Bmediated synaptic currents in midbrain dopaminergic neurons. Soc Neurosci Abstr 33:462466
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Zou, S., & Kumar, U. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19030833 · Cited by 1,448
An Introduction to the Endogenous Cannabinoid System
Lu, H.-C., & Mackie, K. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.07.028 · Cited by 1,234
Self-citationCannabinoid Receptors: Where They are and What They do
Mackie, K. (2008) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2008.01671.x · Cited by 638
Self-citationCB2: a cannabinoid receptor with an identity crisis
Atwood, B. K., & Mackie, K. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2010.00729.x · Cited by 659
Self-citationCristino, L., PETROCELLIS, L. D., Pryce, G., Baker, D., Guglielmotti, V., & Marzo, V. D. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.02.074 · Cited by 489
Metadata
- Authors
- Mackie, K.
- Affiliations
- University of Washington (US)
- Corresponding author
- Mackie, K.
- ORCID
- Mackie, K.
- Venue
- Handbook of Experimental Pharmacology
- Publisher
- Springer-Verlag
- Published
- 2005-12-23
- Issue
- 168
- Pages
- 299-325
- OpenAlex
- W2149183149
- Cited by
- 744
- References
- 103
- Citations by year
- 2026: 28 · 2025: 38 · 2024: 47 · 2023: 56 · 2022: 59 · 2021: 69 · 2020: 48 · 2019: 52 · 2018: 40 · 2017: 37 · 2016: 33 · 2015: 31 · 2014: 26 · 2013: 27 · 2012: 32
- FWCI
- 26.30
- Type
- book chapter
- Language
- en
- Open access
- closed
- Locations
- Springer eBooks (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Drug Abuse (DA00286, DA11322, R01DA011322, K02DA000286)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Cannabis and Cannabinoid Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
- Keywords
- CB1 receptor, cannabinoid receptors, endocannabinoid system, delta-9-tetrahydrocannabinol, G protein-coupled receptors, receptor distribution, central nervous system, peripheral nervous system, hippocampus, amygdala, cerebellum, basal ganglia, neurotransmission
- MeSH terms
- Animals, Autoradiography, Central Nervous System, Humans, Immunohistochemistry, In Situ Hybridization, Peripheral Nervous System, Receptor, Cannabinoid, CB1, Receptor, Cannabinoid, CB2
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