Cited by 751Cannabis and Cannabinoid ResearchNeuroscience and Neuropharmacology ResearchReceptor Mechanisms and Signaling

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Distribution of Cannabinoid Receptors in the Central and Peripheral Nervous System

Mackie, K.·2005·Handbook of Experimental Pharmacology

DOI 10.1007/3-540-26573-2_10

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Abstract

CB1 cannabinoid receptors appear to mediate most, if not all of the psychoactive effects of delta-9-tetrahydrocannabinol and related compounds. This G protein-coupled receptor has a characteristic distribution in the nervous system: It is particularly enriched in cortex, hippocampus, amygdala, basal ganglia outflow tracts, and cerebellum--a distribution that corresponds to the most prominent behavioral effects of cannabis. In addition, this distribution helps to predict neurological and psychological maladies for which manipulation of the endocannabinoid system might be beneficial. CB1 receptors are primarily expressed on neurons, where most of the receptors are found on axons and synaptic terminals, emphasizing the important role of this receptor in modulating neurotransmission at specific synapses. While our knowledge of CB1 localization in the nervous system has advanced tremendously over the past 15 years, there is still more to learn. Particularly pressing is the need for (1) detailed anatomical studies of brain regions important in the therapeutic actions of drugs that modify the endocannabinoid system and (2) the determination of the localization of the enzymes that synthesize, degrade, and transport the endocannabinoids.

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Authors: Mackie, K.
Affiliations: University of Washington (US)
Corresponding author: Mackie, K.
ORCID: Mackie, K.
Venue: Handbook of Experimental Pharmacology
Publisher: Springer-Verlag
Published: 2005-12-23
Issue: 168
Pages: 299-325
DOI: 10.1007/3-540-26573-2_10
OpenAlex: W2149183149
Cited by: 744
References: 103
Citations by year: 2026: 28 · 2025: 38 · 2024: 47 · 2023: 56 · 2022: 59 · 2021: 69 · 2020: 48 · 2019: 52 · 2018: 40 · 2017: 37 · 2016: 33 · 2015: 31 · 2014: 26 · 2013: 27 · 2012: 32
FWCI: 26.30
Type: book chapter
Language: en
Open access: closed
Locations: Springer eBooks (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute on Drug Abuse (DA00286, DA11322, R01DA011322, K02DA000286)
Topics: Health Sciences › Medicine › Pharmacology (medical) › Cannabis and Cannabinoid Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
Keywords: CB1 receptor, cannabinoid receptors, endocannabinoid system, delta-9-tetrahydrocannabinol, G protein-coupled receptors, receptor distribution, central nervous system, peripheral nervous system, hippocampus, amygdala, cerebellum, basal ganglia, neurotransmission
MeSH terms: Animals, Autoradiography, Central Nervous System, Humans, Immunohistochemistry, In Situ Hybridization, Peripheral Nervous System, Receptor, Cannabinoid, CB1, Receptor, Cannabinoid, CB2

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Distribution of Cannabinoid Receptors in the Central and Peripheral Nervous System

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