Adenosine Receptor Ligands as Potential Therapeutic Agents for Impaired Wound Healing and Fibrosis
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PDRN enhances wound healing impaired by diverse pathological conditions, primarily via activation of the A2A receptor and engagement of the nucleotide salvage pathway.
“PDRN has been demonstrated to enhance wound healing impaired by diverse pathological conditions, primarily via activation of the A2A receptor and engagement of the nucleotide salvage pathway, as previously described [111].”
From Comparison of Polynucleotide and Polydeoxyribonucleotide in Dermatology: Molecular Mechanisms and Clinical Perspectives (2025) · cites this paper as [111]
Cites
Fibroblasts and myofibroblasts in wound healing: Force generation and measurement
Li, B., & Wang, J. H.-C. (2011) · Journal of Tissue Viability · doi:10.1016/j.jtv.2009.11.004 · Cited by 594 · see citing works
Regulation of Inflammation by Adenosine
Haskó, G., & Cronstein, B. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00085 · Cited by 367 · see citing works
Polydeoxyribonucleotide: A Promising Biological Platform to Accelerate Impaired Skin Wound Healing
Galeano, M., Pallio, G., Irrera, N., Mannino, F., Bitto, A., Altavilla, D., Vaccaro, M., Squadrito, G., Arcoraci, V., Colonna, M. R., et al. (2021) · Pharmaceuticals · doi:10.3390/ph14111103 · Cited by 79 · see citing works
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Kim, S. T. (2025) · Pharmaceutics · doi:10.3390/pharmaceutics17081024 · Cited by 18 · see citing works
- Authors
- Varano, F., Catarzi, D., Vigiani, E., Calenda, S., & Colotta, V.
- Affiliations
- University of Florence (IT)
- Corresponding author
- Varano, Flavia
- Venue
- Topics in Medicinal Chemistry
- Publisher
- Springer International Publishing
- Published
- 2022
- Pages
- 89-99
- ISSN
- 1862-2461 (ISSN-L)
- 1862-247X
- OpenAlex
- W4313137758
- Cited by
- 1
- References
- 3
- Citations by year
- 2025: 1
- FWCI
- 0.40
- Type
- book chapter
- Language
- en
- Open access
- closed
- Licence
- Locations
- Topics in medicinal chemistry (publishedVersion)
- Florence Research (University of Florence) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Adenosine and Purinergic Signaling
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and biological activity of medicinal plants
- Keywords
- adenosine receptors, adenosine receptor ligands, wound healing, fibrosis, chronic wounds, adenosine A1 receptor, adenosine A2A receptor, adenosine A2B receptor, A3 adenosine receptor, therapeutic agents
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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