Small Interfering RNAs (siRNAs)
Integrity signals
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Each is checked against this paper’s own text: does it say what the citing paper says it does?
Internalized inclisiran enters hepatocyte cytoplasm to form RISC, which uses the antisense portion of the siRNA to find matching PCSK9 mRNA sequences for site-specific cleavage and mRNA degradation.
“The internalized Inclisiran enters hepatocyte cytoplasm to form an RNA-induced silencing complex (RISC). RISC utilizes the antisense portion of the siRNA as a guide to find matching sequences on PCSK9 mRNA for site-specific cleavage that results in mRNA degradation [17].”
The citation lists haven’t been fetched yet
References 77 · Cited by 1
- Authors
- Tosar, J. P.
- Affiliations
- Universidad de la República de Uruguay (UY)
- Corresponding author
- Tosar, Juan Pablo
- ORCID
- Tosar, Juan Pablo
- Venue
- Topics in Medicinal Chemistry
- Publisher
- Springer Nature Switzerland
- Published
- 2024
- Pages
- 149-171
- ISSN
- 1862-2461 (ISSN-L)
- 1862-247X
- OpenAlex
- W4405837301
- Cited by
- 1
- References
- 77
- Citations by year
- 2026: 1
- FWCI
- 0.86
- Type
- book chapter
- Language
- en
- Open access
- closed
- Licence
- Locations
- Topics in medicinal chemistry (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA regulation and disease
- Keywords
- siRNA, RNA interference, siRNA therapeutics, siRNA delivery, lipid nanoparticles, patisiran, chemically modified siRNA, givosiran, lumasiran, inclisiran, vutrisiran, post-transcriptional gene silencing
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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