Molecular Mechanisms of B Cell Antigen Gathering and Endocytosis
Open accessAbstract
Generation of high-affinity, protective antibodies requires B cell receptor (BCR) signaling, as well as antigen internalization and presentation to helper T cells. B cell antigen internalization is initiated by antigen capture, either from solution or from immune synapses formed on the surface of antigen-presenting cells, and proceeds via clathrin-dependent endocytosis and intracellular routing to late endosomes. Although the components of this pathway are still being discovered, it has become clear that antigen internalization is actively regulated by BCR signaling at multiple steps and, vice versa, that localization of the BCR along the endocytic pathway modulates signaling. Accordingly, defects in BCR internalization or trafficking contribute to enhanced B cell activation in models of autoimmune diseases and in B cell lymphomas. In this review, we discuss how BCR signaling complexes regulate each of the steps of this endocytic process and why defects along this pathway manifest as hyperactive B cell responses in vivo.
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The adaptive immune system of vertebrates functions largely by recognition of foreign peptide sequences, which are directly recognized by the B cell surface Ig receptor and are also loaded into MHC molecules to be presented to specific T-cell receptors.
“The adaptive immune system of vertebrate organisms functions largely by recognition of foreign peptide sequences, which are directly recognized by the B cell surface Ig receptor (584 -585), and are also loaded into the grooves of the major histocompatibility receptors to be presented to speci fi c T-cell receptors (586).”
From Biological roles of glycans (2017) · cites this paper as [585]
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Junt, T., Moseman, E. A., Iannacone, M., Massberg, S., Lang, P. A., Boes, M., Fink, K., Henrickson, S. E., Shayakhmetov, D. M., Di Paolo, N. C., et al. (2007) · Nature · doi:10.1038/nature06287 · Cited by 846 · see citing works
The First Five Seconds in the Life of a Clathrin-Coated Pit
Cocucci, E., Aguet, F., Boulant, S., & Kirchhausen, T. (2012) · Cell · doi:10.1016/j.cell.2012.05.047 · Cited by 391 · cited 1× · see citing works
“CCP formation is initiated by binding of the adaptor protein AP-2 to phosphatidyl inositol (PI)(4, 5) bisphosphate (P2) in the plasma membrane (Cocucci et al. 2012).”
BackgroundWeber, M., Treanor, B., Depoil, D., Shinohara, H., Harwood, N. E., Hikida, M., Kurosaki, T., & Batista, F. D. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20072619 · Cited by 170 · see citing works
Systems‐wide analysis of BCR signalosomes and downstream phosphorylation and ubiquitylation
Satpathy, S., Wagner, S. A., Beli, P., Gupta, R., Kristiansen, T. A., Malinova, D., Francavilla, C., Tolar, P., Bishop, G. A., Hostager, B. S., et al. (2015) · Molecular Systems Biology · doi:10.15252/msb.20145880 · Cited by 124 · see citing works
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Varki, A. (2017) · Glycobiology · doi:10.1093/glycob/cww086 · Cited by 2,635 · see citing works
Toll-like receptor 9 antagonizes antibody affinity maturation
Akkaya, M., Akkaya, B., Kim, A. S., Miozzo, P., Sohn, H., Pena, M., Roesler, A. S., Theall, B. P., Henke, T., Kabat, J., et al. (2018) · Nature Immunology · doi:10.1038/s41590-018-0052-z · Cited by 66 · see citing works
- Authors
- Hoogeboom, R., & Tolar, P.
- Affiliations
- National Institute for Medical Research (GB)
- Corresponding author
- Tolar, Pavel
- Venue
- Current Topics in Microbiology and Immunology
- Publisher
- Springer International Publishing
- Published
- 2015
- Volume
- 393
- Pages
- 45-63
- ISSN
- 0070-217X (ISSN-L)
- 2196-9965
- OpenAlex
- W1751302486
- Cited by
- 48
- References
- 4
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 5 · 2023: 8 · 2022: 5 · 2021: 6 · 2020: 4 · 2019: 6 · 2018: 2 · 2017: 2 · 2016: 4
- FWCI
- 5.43
- Type
- book chapter
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Current topics in microbiology and immunology (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Research Portal (King's College London) (submittedVersion)
- Funders
- Francis Crick Institute (10185)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- B cell receptor signaling, antigen uptake, antigen capture, clathrin-mediated endocytosis, antigen presentation, immunological synapse, antigen-presenting cells, late endosomes, B cell activation, autoimmunity, B-cell lymphoma
- MeSH terms
- Animals, B-Lymphocytes, Endocytosis, Humans, Receptors, Antigen, B-Cell, Endosomes, Signal Transduction, Protein Transport
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