Phospholipase C-γ2 and Vav cooperate within signaling microclusters to propagate B cell spreading in response to membrane-bound antigen

The Immunological Synapse: A Molecular Machine Controlling T Cell Activation

Grakoui, A., Bromley, S. K., Sumen, C., Davis, M. M., Shaw, A. S., Allen, P. M., & Dustin, M. L. (1999) · Science · doi:10.1126/science.285.5425.221 · Cited by 3,110 · see citing works

RHO GTPASES: Biochemistry and Biology

Jaffe, A. B., & Hall, A. (2005) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.21.020604.150721 · Cited by 3,009 · see citing works

Three-dimensional segregation of supramolecular activation clusters in T cells

Monks, C. R. F., Freiberg, B. A., Kupfer, H., Sciaky, N., & Kupfer, A. (1998) · Nature · doi:10.1038/25764 · Cited by 2,353 · see citing works

Regulation of Phosphoinositide-Specific Phospholipase C

Rhee, S. G. (2001) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.70.1.281 · Cited by 1,628 · see citing works

Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice

Goodnow, C. C., Crosbie, J. C., Adelstein, S., Lavoie, T., Smith‐Gill, S. J., Brink, R. A., Pritchard-Briscoe, H., Wotherspoon, J. S., Loblay, R. H., Raphael, K., et al. (1988) · Nature · doi:10.1038/334676a0 · Cited by 1,568 · see citing works

T Cell Receptor-Proximal Signals Are Sustained in Peripheral Microclusters and Terminated in the Central Supramolecular Activation Cluster

Varma, R., Campi, G., Yokosuka, T., Saito, T., & Dustin, M. L. (2006) · Immunity · doi:10.1016/j.immuni.2006.04.010 · Cited by 880 · see citing works

Subcapsular sinus macrophages in lymph nodes clear lymph-borne viruses and present them to antiviral B cells

Junt, T., Moseman, E. A., Iannacone, M., Massberg, S., Lang, P. A., Boes, M., Fink, K., Henrickson, S. E., Shayakhmetov, D. M., Di Paolo, N. C., et al. (2007) · Nature · doi:10.1038/nature06287 · Cited by 846 · see citing works

B lymphocyte-specific, Cre-mediated mutagenesis in mice

Rickert, R. (1997) · Nucleic Acids Research · doi:10.1093/nar/25.6.1317 · Cited by 724 · see citing works

Newly generated T cell receptor microclusters initiate and sustain T cell activation by recruitment of Zap70 and SLP-76

Yokosuka, T., Sakata-Sogawa, K., Kobayashi, W., Hiroshima, M., Hashimoto, A. S., Tokunaga, M., Dustin, M. L., & Saito, T. (2005) · Nature Immunology · doi:10.1038/ni1272 · Cited by 702 · see citing works

Tyrosine kinases Lyn and Syk regulate B cell receptor‐coupled Ca2+ mobilization through distinct pathways.

Takata, M., Sabe, H., Hata, A., Inazu, T., Homma, Y., Nukada, T., Yamamura, H., & Kurosaki, T. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06387.x · Cited by 650 · see citing works

Subcapsular encounter and complement-dependent transport of immune complexes by lymph node B cells

Phan, T. G., Grigorova, I., Okada, T., & Cyster, J. G. (2007) · Nature Immunology · doi:10.1038/ni1494 · Cited by 644 · see citing works

Actin and agonist MHC–peptide complex–dependent T cell receptor microclusters as scaffolds for signaling

Campi, G., Varma, R., & Dustin, M. L. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20051182 · Cited by 639 · see citing works

T cell receptor ligation induces the formation of dynamically regulated signaling assemblies

Bunnell, S. C., Hong, D. I., Kardon, J. R., Yamazaki, T., McGlade, C. J., Barr, V. A., & Samelson, L. E. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200203043 · Cited by 633 · see citing works

B cells acquire antigen from target cells after synapse formation

Batista, F. D., Iber, D., & Neuberger, M. S. (2001) · Nature · doi:10.1038/35078099 · Cited by 629 · see citing works

Regulation of B-cell fate by antigen-receptor signals

Niiro, H., & Clark, E. A. (2002) · Nature reviews. Immunology · doi:10.1038/nri955 · Cited by 626 · see citing works

Blood Dendritic Cells Interact with Splenic Marginal Zone B Cells to Initiate T-Independent Immune Responses

Balázs, M., Martin, F., Zhou, T., & Kearney, J. F. (2002) · Immunity · doi:10.1016/s1074-7613(02)00389-8 · Cited by 624 · see citing works

B Cells Acquire Particulate Antigen in a Macrophage-Rich Area at the Boundary between the Follicle and the Subcapsular Sinus of the Lymph Node

Carrasco, Y. R., & Batista, F. D. (2007) · Immunity · doi:10.1016/j.immuni.2007.06.007 · Cited by 611 · see citing works

Activation of phospholipase Cγ by PI 3‐kinase‐induced PH domain‐mediated membrane targeting

Falasca, M., Logan, S. K., Lehto, V. P., Baccante, G., Lemmon, M. A., & Schlessinger, J. (1998) · The EMBO Journal · doi:10.1093/emboj/17.2.414 · Cited by 557 · see citing works

B cell antigen receptor signaling 101

DalPorto, J. (2004) · Molecular Immunology · doi:10.1016/j.molimm.2004.04.008 · Cited by 538 · see citing works

Regulation of B Lymphocyte Responses to Foreign and Self-Antigens by the CD19/CD21 Complex

Fearon, D. T., Carroll, M. C., & Carroll, M. C. (2000) · Annual Review of Immunology · doi:10.1146/annurev.immunol.18.1.393 · Cited by 529 · see citing works

Untitled work

Fu (1998) · doi:10.1016/s1074-7613(00)80591-9 · Cited by 518 · see citing works

A Transgenic Mouse Line That Retains Cre Recombinase Activity in Mature Oocytes Irrespective of thecreTransgene Transmission

Sakai, K., & Miyazaki, J. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.7111 · Cited by 494 · see citing works

Dendritic Cells Interact Directly with Naive B Lymphocytes to Transfer Antigen and Initiate Class Switching in a Primary T-Dependent Response

Wykes, M., Pombo, A., Jenkins, C., & MacPherson, G. G. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.3.1313 · Cited by 461 · see citing works

INITIATION AND PROCESSING OF SIGNALS FROM THE B CELL ANTIGEN RECEPTOR

Reth, M. G., & Wienands, J. (1997) · Annual Review of Immunology · doi:10.1146/annurev.immunol.15.1.453 · Cited by 436 · see citing works

GENETIC ANALYSIS OF B CELL ANTIGEN RECEPTOR SIGNALING

Kurosaki, T. (1999) · Annual Review of Immunology · doi:10.1146/annurev.immunol.17.1.555 · Cited by 433 · see citing works

Phosphatidylinositol‐3,4,5‐trisphosphate (PtdIns‐3,4,5‐P3)/Tec kinase‐dependent calcium signaling pathway: a target for SHIP‐mediated inhibitory signals

Scharenberg, A. M., El-Hillal, O., Fruman, D. A., Beitz, L., Li, Z., Lin, S., Gout, I. T., Cantley, L. C., Rawlings, D. J., & Kinet, J.-P. (1998) · The EMBO Journal · doi:10.1093/emboj/17.7.1961 · Cited by 428 · see citing works

B Cell Ligand Discrimination Through a Spreading and Contraction Response

Fleire, S. J., Goldman, J., Carrasco, Y. R., Weber, M., Bray, D., & Batista, F. D. (2006) · Science · doi:10.1126/science.1123940 · Cited by 425 · see citing works

Genetic evidence for involvement of type 1, type 2 and type 3 inositol 1,4,5‐trisphosphate receptors in signal transduction through the B‐cell antigen receptor

Sugawara, H., Kurosaki, M., Takata, M., & Kurosaki, T. (1997) · The EMBO Journal · doi:10.1093/emboj/16.11.3078 · Cited by 410 · see citing works

Dynamic Actin Polymerization Drives T Cell Receptor–Induced Spreading

Bunnell, S. C., Kapoor, V., Trible, R. P., Zhang, W., & Samelson, L. E. (2001) · Immunity · doi:10.1016/s1074-7613(01)00112-1 · Cited by 409 · see citing works

Btk/Tec kinases regulate sustained increases in intracellular Ca2+ following B‐cell receptor activation

Fluckiger, A.-C., Li, Z., Kato, R. M., Wahl, M. I., Ochs, H. D., Longnecker, R., Kinet, J.-P., Witte, O. N., Scharenberg, A. M., & Rawlings, D. J. (1998) · The EMBO Journal · doi:10.1093/emboj/17.7.1973 · Cited by 403 · see citing works

Defects in actin-cap formation in Vav-deficient mice implicate an actin requirement for lymphocyte signal transduction

Holsinger, L. J., Graef, I. A., Swat, W., Chi, T., Bautista, D. M., Davidson, L., Lewis, R. S., Alt, F. W., & Crabtree, G. R. (1998) · Current Biology · doi:10.1016/s0960-9822(98)70225-8 · Cited by 402 · see citing works

SHIP Modulates Immune Receptor Responses by Regulating Membrane Association of Btk

Bolland, S. M., Pearse, R. N., Kurosaki, T., & Ravetch, J. V. (1998) · Immunity · doi:10.1016/s1074-7613(00)80555-5 · Cited by 384 · see citing works

CD19 is essential for B cell activation by promoting B cell receptor–antigen microcluster formation in response to membrane-bound ligand

Depoil, D., Fleire, S. J., Treanor, B., Weber, M., Harwood, N. E., Marchbank, K. J., Tybulewicz, V. L. J., & Batista, F. D. (2007) · Nature Immunology · doi:10.1038/ni1547 · Cited by 369 · see citing works

LFA-1/ICAM-1 Interaction Lowers the Threshold of B Cell Activation by Facilitating B Cell Adhesion and Synapse Formation

Carrasco, Y. R., Fleire, S. J., Cameron, T. O., Dustin, M. L., & Batista, F. D. (2004) · Immunity · doi:10.1016/s1074-7613(04)00105-0 · Cited by 345 · see citing works

The complexity of signaling pathways activated by the BCR

DeFranco, A. L. (1997) · Current Opinion in Immunology · doi:10.1016/s0952-7915(97)80074-x · Cited by 318 · see citing works

BLNK Required for Coupling Syk to PLCγ2 and Rac1-JNK in B Cells

Ishiai, M., Kurosaki, M., Pappu, R., Okawa, K., Ronko, I., Fu, C., Shibata, M., Iwamatsu, A., Chan, A. C., & Kurosaki, T. (1999) · Immunity · doi:10.1016/s1074-7613(00)80012-6 · Cited by 318 · see citing works

Cofilin takes the lead

DesMarais, V. M., Ghosh, M., Eddy, R. J., & Condeelis, J. S. (2004) · Journal of Cell Science · doi:10.1242/jcs.01631 · Cited by 301 · see citing works

Exclusion of CD43 from the Immunological Synapse Is Mediated by Phosphorylation-Regulated Relocation of the Cytoskeletal Adaptor Moesin

Delon, J., Kaibuchi, K., & Germain, R. N. (2001) · Immunity · doi:10.1016/s1074-7613(01)00231-x · Cited by 287 · see citing works

ERM proteins regulate cytoskeleton relaxation promoting T cell–APC conjugation

Faure, S., Salazar-Fontana, L., Sémichon, M., Tybulewicz, V., Bismuth, G., Trautmann, A., Germain, R., & Delon, J. (2004) · Nature Immunology · doi:10.1038/ni1039 · Cited by 286 · see citing works

Knockouts of Src-family kinases: stiff bones, wimpy T cells, and bad memories.Preprint

Lowell, C. A., & Soriano, P. M. (1996) · Genes & Development · doi:10.1101/gad.10.15.1845 · Cited by 285 · see citing works

SLP-65: A New Signaling Component in B Lymphocytes which Requires Expression of the Antigen Receptor for Phosphorylation

Wienands, J., Schweikert, J., Wollscheid, B., Jumaa, H., Nielsen, P. J., & Reth, M. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.4.791 · Cited by 271 · see citing works

Calcium signalling and cell-fate choice in B cells

Scharenberg, A. M., Humphries, L. A., & Rawlings, D. J. (2007) · Nature Reviews Immunology · doi:10.1038/nri2172 · Cited by 225 · see citing works

A novel in vivo follicular dendritic cell-dependent iccosome-mediated mechanism for delivery of antigen to antigen-processing cells.

Szakal, A. K., Kosco, M. H., & Tew, J. G. (1988) · The Journal of Immunology · doi:10.4049/jimmunol.140.2.341 · Cited by 224 · see citing works

Vav proteins, masters of the world of cytoskeleton organization

Hornstein, I., Alcover, A., & Katzav, S. (2003) · Cellular Signalling · doi:10.1016/s0898-6568(03)00110-4 · Cited by 223 · see citing works

Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice.

Goodnow, C. C., Crosbie, J., Adelstein, S., Lavoie, T., Smith‐Gill, S. J., Brink, R. A., Pritchard-Briscoe, H., Wotherspoon, J. S., Loblay, R. H., Raphael, K., et al. (2009) · PubMed · Cited by 221 · see citing works

Vav1 Transduces T Cell Receptor Signals to the Activation of Phospholipase C-γ1 via Phosphoinositide 3-Kinase-dependent and -independent Pathways

Reynolds, L. F., Smyth, L. A., Norton, T., Freshney, N. W., Downward, J., Kioussis, D., & Tybulewicz, V. L. J. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20011663 · Cited by 217 · see citing works

HS1 Functions as an Essential Actin-Regulatory Adaptor Protein at the Immune Synapse

Gomez, T. S., McCarney, S., Carrizosa, E., Labno, C. M., Comiskey, E. O., Nolz, J. C., Zhu, P., Freedman, B. D., Clark, M. R., Rawlings, D. J., et al. (2006) · Immunity · doi:10.1016/j.immuni.2006.03.022 · Cited by 209 · see citing works

Regulation of B-cell signal transduction by adaptor proteins

Kurosaki, T. (2002) · Nature Reviews Immunology · doi:10.1038/nri801 · Cited by 209 · see citing works

Identification of the SH2 Domain Binding Protein of Bruton’s Tyrosine Kinase as BLNK—Functional Significance of Btk-SH2 Domain in B-Cell Antigen Receptor-Coupled Calcium Signaling

Hashimoto, S., Iwamatsu, A., Ishiai, M., Okawa, K., Yamadori, T., Matsushita, M., Baba, Y., Kishimoto, T., Kurosaki, T., & Tsukada, S. (1999) · Blood · doi:10.1182/blood.v94.7.2357.419k40_2357_2364 · Cited by 206 · see citing works

Quantitative proteomic analysis of B cell lipid rafts reveals that ezrin regulates antigen receptor–mediated lipid raft dynamics

Gupta, N., Wollscheid, B., Watts, J. D., Scheer, B., Aebersold, R. H., & DeFranco, A. L. (2006) · Nature Immunology · doi:10.1038/ni1337 · Cited by 195 · see citing works

Xid-like Phenotypes

Fruman, D. A., Satterthwaite, A. B., & Witte, O. N. (2000) · Immunity · doi:10.1016/s1074-7613(00)00002-9 · Cited by 191 · see citing works

Signal transduction through Vav-2 participates in humoral immune responses and B cell maturation

Doody, G. M., Bell, S. E., Vigorito, E., Clayton, E., McAdam, S., Tooze, R. M., Fernandez, C., Lee, I. J., & Turner, M. (2001) · Nature Immunology · doi:10.1038/88748 · Cited by 177 · see citing works

CD19 as a Membrane-Anchored Adaptor Protein of B Lymphocytes: Costimulation of Lipid and Protein Kinases by Recruitment of Vav

O'Rourke, L. M., Tooze, R. M., Turner, M., Sandoval, D. M., Carter, R. H., Tybulewicz, V. L. J., & Fearon, D. T. (1998) · Immunity · doi:10.1016/s1074-7613(00)80568-3 · Cited by 175 · see citing works

A short sequence responsible for both phosphoinositide binding and actin binding activities of cofilin.

Yonezawa, N., Homma, Y., Yahara, I., Sakai, H., & Nishida, E. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)47361-4 · Cited by 175 · see citing works

Evidence for an IgD homologue on chicken lymphocytes.

Chen, C.-L. H., Lehmeyer, J. E., & Cooper, M. D. (1982) · The Journal of Immunology · doi:10.4049/jimmunol.129.6.2580 · Cited by 160 · see citing works

Cutting Edge: Essential Role of Phospholipase C-γ2 in B Cell Development and Function

Hashimoto, A., Takeda, K., Inaba, M., Sekimata, M., Kaisho, T., Ikehara, S., Homma, Y., Akira, S., & Kurosaki, T. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.4.1738 · Cited by 155 · see citing works

Vav1 Regulates Phospholipase Cγ Activation and Calcium Responses in Mast Cells

Manetz, T. S., González‐Espinosa, C., Arudchandran, R., Xirasagar, S., Tybulewicz, V. L. J., & Rivera, J. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.11.3763-3774.2001 · Cited by 155 · see citing works

RasGRP1 and RasGRP3 Regulate B Cell Proliferation by Facilitating B Cell Receptor-Ras Signaling

Coughlin, J. J., Stang, S. L., Dower, N. A., & Stone, J. C. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.11.7179 · Cited by 154 · see citing works

Signaling through CD19 activates Vav/mitogen-activated protein kinase pathway and induces formation of a CD19/Vav/phosphatidylinositol 3-kinase complex in human B cell precursors.

Weng, W., Jarvis, L. J., & LeBien, T. W. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)31664-8 · Cited by 145 · see citing works

BASH, a novel signaling molecule preferentially expressed in B cells of the bursa of Fabricius.

Goitsuka, R., Fujimura, Y., Mamada, H., Umeda, A., Morimura, T., Uetsuka, K., Doi, K., Tsuji, S., & Kitamura, D. (1998) · PubMed · Cited by 145 · see citing works

Vav3 Modulates B Cell Receptor Responses by Regulating Phosphoinositide 3-Kinase Activation

Inabe, K., Ishiai, M., Scharenberg, A. M., Freshney, N. W., Downward, J., & Kurosaki, T. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20011571 · Cited by 142 · see citing works

Four Tyrosine Residues in Phospholipase C-γ2, Identified as Btk-dependent Phosphorylation Sites, Are Required for B Cell Antigen Receptor-coupled Calcium Signaling

Watanabe, D., Hashimoto, S., Ishiai, M., Matsushita, M., Baba, Y., Kishimoto, T., Kurosaki, T., & Tsukada, S. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m103675200 · Cited by 136 · see citing works

Mechanism of B-Cell Receptor-Induced Phosphorylation and Activation of Phospholipase C-γ2

Kim, Y. J., Sekiya, F., Poulin, B., Bae, Y. S., & Rhee, S. G. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.22.9986-9999.2004 · Cited by 126 · see citing works

BLNK: molecular scaffolding through ‘cis’‐mediated organization of signaling proteins

Chiu, C. W., Dalton, M., Ishiai, M., Kurosaki, T., & Chan, A. C. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf658 · Cited by 122 · see citing works

Phospholipase C-γ: diverse roles in receptor-mediated calcium signaling

Patterson, R. L., van Rossum, D. B., Nikolaidis, N., Gill, D. L., & Snyder, S. H. (2005) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2005.10.005 · Cited by 121 · see citing works

Recruitment and activation of PLCγ1 in T cells: a new insight into old domains

Braiman, A., Barda‐Saad, M., Sommers, C. L., & Samelson, L. E. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7600978 · Cited by 116 · see citing works

Cutting Edge: BASH, A Novel Signaling Molecule Preferentially Expressed in B Cells of the Bursa of Fabricius

Goitsuka, R., Fujimura, Y., Mamada, H., Umeda, A., Morimura, T., Uetsuka, K., Doi, K., Tsuji, S., & Kitamura, D. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.11.5804 · Cited by 115 · see citing works

Requirement for Ras Guanine Nucleotide Releasing Protein 3 in Coupling Phospholipase C-γ2 to Ras in B Cell Receptor Signaling

Oh-hora, M., Johmura, S., Hashimoto, A., Hikida, M., & Kurosaki, T. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20031547 · Cited by 113 · see citing works

Role of Tyrosine Phosphorylation of HS1 in B Cell Antigen Receptor-mediated Apoptosis

Yamanashi, Y., Fukuda, T., Nishizumi, H., Inazu, T., Higashi, K., Kitamura, D., Ishida, T., Yamamura, H., Watanabe, T., & Yamamoto, T. S. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.185.7.1387 · Cited by 112 · see citing works

The role of membrane-associated adaptors in T cell receptor signalling

Zhang, W., & Samelson, L. E. (2000) · Seminars in Immunology · doi:10.1006/smim.2000.0205 · Cited by 110 · see citing works

Regulation of B cell fates by BCR signaling components

Kurosaki, T. (2002) · Current Opinion in Immunology · doi:10.1016/s0952-7915(02)00344-8 · Cited by 106 · see citing works

Tec Kinases Mediate Sustained Calcium Influx via Site-specific Tyrosine Phosphorylation of the Phospholipase Cγ Src Homology 2-Src Homology 3 Linker

Humphries, L. A., Dangelmaier, C., Sommer, K., Kipp, K. R., Kato, R. M., Griffith, N., Bakman, I., Turk, C. W., Daniel, J. L., & Rawlings, D. J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m311985200 · Cited by 103 · see citing works

Follicular dendritic cell-derived antigen and accessory activity in initiation of memory IgG responses in vitro

Wu, J., Qin, D., Burton, G. F., Szakal, A. K., & Tew, J. G. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.157.8.3404 · Cited by 97 · see citing works

The adaptor protein 3BP2 associates with VAV guanine nucleotide exchange factors to regulate NFAT activation by the B-cell antigen receptor

Foucault, I., Bras, S. L., Charvet, C., Moon, C., Altman, A., & Deckert, M. (2004) · Blood · doi:10.1182/blood-2003-08-2965 · Cited by 86 · see citing works

Regulation of In Vitro and In Vivo Immune Functions by the Cytosolic Adaptor Protein SKAP-HOM

Togni, M., Swanson, K. D., Reimann, S., Kliche, S., Pearce, A. C., Simeoni, L., Reinhold, D., Wienands, J., Neel, B. G., Schraven, B. L., et al. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.18.8052-8063.2005 · Cited by 85 · see citing works

3BP2 Deficiency Impairs the Response of B Cells, but Not T Cells, to Antigen Receptor Ligation

de la Fuente, M. Á., Kumar, L., Lu, B., & Geha, R. S. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.00087-06 · Cited by 46 · see citing works

Syk-mediated Tyrosine Phosphorylation Is Required for the Association of Hematopoietic Lineage Cell-specific Protein 1 with Lipid Rafts and B Cell Antigen Receptor Signalosome Complex

Hao, J.-J., Carey, G. B., & Zhan, X. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m313564200 · Cited by 42 · see citing works

Vav-Dependent and Vav-Independent Phosphatidylinositol 3-Kinase Activation in Murine B Cells Determined by the Nature of the Stimulus

Vigorito, E., Bardi, G., Glassford, J., Lam, E. W. ‐., Clayton, E., & Turner, M. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.5.3209 · Cited by 40 · see citing works

Vav and the B cell signalosome

DeFranco, A. L. (2001) · Nature Immunology · doi:10.1038/88669 · Cited by 40 · see citing works

B Cell Antigen Receptor-Induced Rac1 Activation and Rac1-Dependent Spreading Are Impaired in Transitional Immature B Cells Due to Levels of Membrane Cholesterol

Brezski, R. J., & Monroe, J. G. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.7.4464 · Cited by 31 · see citing works

Binding of Cytoplasmic Proteins to the CD19 Intracellular Domain Is High Affinity, Competitive, and Multimeric

Brooks, S. R., Kirkham, P. M., Freeberg, L. E., & Carter, R. H. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.12.7556 · Cited by 30 · see citing works

Immunogenicity of a contiguous T-B synthetic epitope of the A/PR/8/34 influenza virus

Brumeanu, T., Casares, S. A., Bot, A. I., Bot, S., & Bona, C. A. (1997) · Journal of Virology · doi:10.1128/jvi.71.7.5473-5480.1997 · Cited by 29 · see citing works

Genetic analysis of B cell signaling

Shinohara, H., & Kurosaki, T. (2006) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-1-4020-4896-8_10 · Cited by 23 · see citing works

Mechanistic insight into lymphocyte activation through quantitative imaging and theoretical modelling

Treanor, B., & Batista, F. D. (2007) · Current Opinion in Immunology · doi:10.1016/j.coi.2007.05.009 · Cited by 19 · see citing works

Programmed cell death 1 forms negative costimulatory microclusters that directly inhibit T cell receptor signaling by recruiting phosphatase SHP2

Yokosuka, T., Takamatsu, M., Kobayashi-Imanishi, W., Hashimoto-Tane, A., Azuma, M., & Saito, T. (2012) · Journal of Experimental Medicine · doi:10.1084/jem.20112741 · Cited by 1,161 · see citing works

The who, how and where of antigen presentation to B cells

Batista, F. D., & Harwood, N. E. (2008) · Nature reviews. Immunology · doi:10.1038/nri2454 · Cited by 775 · see citing works

Role of Bruton’s tyrosine kinase in B cells and malignancies

Pal Singh, S., Dammeijer, F., & Hendriks, R. W. (2018) · Molecular Cancer · doi:10.1186/s12943-018-0779-z · Cited by 726 · see citing works

Targeting Bruton's tyrosine kinase in B cell malignancies

Hendriks, R. W., Yuvaraj, S., & Kil, L. P. (2014) · Nature reviews. Cancer · doi:10.1038/nrc3702 · Cited by 564 · see citing works

Early Events in B Cell Activation

Harwood, N. E., & Batista, F. D. (2010) · Annual Review of Immunology · doi:10.1146/annurev-immunol-030409-101216 · Cited by 404 · see citing works

B Cell Signaling and Fate Decision

Kurosaki, T., Shinohara, H., & Baba, Y. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132541 · Cited by 354 · see citing works

The Actin and Tetraspanin Networks Organize Receptor Nanoclusters to Regulate B Cell Receptor-Mediated Signaling

Mattila, P. K., Feest, C., Depoil, D., Treanor, B., Montaner, B., Otipoby, K. L., Carter, R., Justement, L. B., Bruckbauer, A., & Batista, F. D. (2013) · Immunity · doi:10.1016/j.immuni.2012.11.019 · Cited by 327 · see citing works

The Membrane Skeleton Controls Diffusion Dynamics and Signaling through the B Cell Receptor

Treanor, B., Depoil, D., Gonzalez-Granja, A., Barral, P., Weber, M., Dushek, O., Bruckbauer, A., & Batista, F. D. (2010) · Immunity · doi:10.1016/j.immuni.2009.12.005 · Cited by 317 · see citing works

How B cells capture, process and present antigens: a crucial role for cell polarity

Yuseff, M.-I., Pierobon, P., Reversat, A., & Lennon‐Duménil, A. (2013) · Nature reviews. Immunology · doi:10.1038/nri3469 · Cited by 308 · see citing works

Rho family GTPases and their regulators in lymphocytes

Tybulewicz, V. L. J., & Henderson, R. B. (2009) · Nature reviews. Immunology · doi:10.1038/nri2606 · Cited by 288 · see citing works

The Constant Region of the Membrane Immunoglobulin Mediates B Cell-Receptor Clustering and Signaling in Response to Membrane Antigens

Tolar, P., Hanna, J., Krueger, P. D., & Pierce, S. K. (2009) · Immunity · doi:10.1016/j.immuni.2008.11.007 · Cited by 224 · see citing works

Fine tuning the immune response with PI3K

Fruman, D. A., & Bismuth, G. (2009) · Immunological Reviews · doi:10.1111/j.1600-065x.2008.00750.x · Cited by 201 · see citing works

Germinal center B cells recognize antigen through a specialized immune synapse architecture

Nowosad, C. R., Spillane, K. M., & Tolar, P. (2016) · Nature Immunology · doi:10.1038/ni.3458 · Cited by 195 · see citing works

The tipping points in the initiation of B cell signalling: how small changes make big differences

Pierce, S. K., & Liu, W. (2010) · Nature reviews. Immunology · doi:10.1038/nri2853 · Cited by 193 · see citing works

B‐cell stage and context‐dependent requirements for survival signals from BAFF and the B‐cell receptor

Mackay, F., Figgett, W. A., Saulep-Easton, D., LePage, M., & Hibbs, M. L. (2010) · Immunological Reviews · doi:10.1111/j.1600-065x.2010.00944.x · Cited by 182 · see citing works

Dynamic cortical actin remodeling by ERM proteins controls BCR microcluster organization and integrity

Treanor, B., Depoil, D., Bruckbauer, A., & Batista, F. D. (2011) · The Journal of Experimental Medicine · doi:10.1084/jem.20101125 · Cited by 172 · see citing works

BTK inhibitors in the treatment of hematological malignancies and inflammatory diseases: mechanisms and clinical studies

Alu, A., Lei, H., Han, X., Wei, Y., & Wei, X. (2022) · Journal of Hematology & Oncology · doi:10.1186/s13045-022-01353-w · Cited by 157 · see citing works

New Insights into the Early Molecular Events Underlying B Cell Activation

Harwood, N. E., & Batista, F. D. (2008) · Immunity · doi:10.1016/j.immuni.2008.04.007 · Cited by 158 · see citing works

Tyrosine kinases and their substrates in B lymphocytes

Kurosaki, T., & Hikida, M. (2009) · Immunological Reviews · doi:10.1111/j.1600-065x.2008.00748.x · Cited by 160 · see citing works

Cytoskeletal control of B cell responses to antigens

Tolar, P. (2017) · Nature reviews. Immunology · doi:10.1038/nri.2017.67 · Cited by 148 · see citing works

The β-Glucan Receptor Dectin-1 Activates the Integrin Mac-1 in Neutrophils via Vav Protein Signaling to Promote Candida albicans Clearance

Li, X., Utomo, A. R. H., Culleré, X., Choi, M., Milner, D. A., Venkatesh, D., Yun, S. H., & Mayadas, T. N. (2011) · Cell Host & Microbe · doi:10.1016/j.chom.2011.10.009 · Cited by 147 · see citing works

Dynamics of the actin cytoskeleton mediates receptor cross talk: An emerging concept in tuning receptor signaling

Mattila, P. K., Batista, F. D., & Treanor, B. (2016) · The Journal of Cell Biology · doi:10.1083/jcb.201504137 · Cited by 142 · see citing works

Pathogenetic importance and therapeutic implications of NF‐κB in lymphoid malignancies

Lim, K., Yang, Y., & Staudt, L. M. (2012) · Immunological Reviews · doi:10.1111/j.1600-065x.2012.01105.x · Cited by 141 · see citing works

Trafficking of B Cell Antigen in Lymph Nodes

González, S., Degn, S. E., Pitcher, L. A., Woodruff, M. C., Heesters, B. A., & Carroll, M. C. (2011) · Annual Review of Immunology · doi:10.1146/annurev-immunol-031210-101255 · Cited by 139 · see citing works

The activation of IgM- or isotype-switched IgG- and IgE-BCR exhibits distinct mechanical force sensitivity and threshold

Wan, Z., Chen, X., Chen, H., Ji, Q., Chen, Y., Wang, J., Cao, Y., Wang, F., Lou, J., Tang, Z., et al. (2015) · eLife · doi:10.7554/elife.06925 · Cited by 135 · see citing works

Signalling complexes and clusters: functional advantages and methodological hurdles

Cebecauer, M., Spitaler, M., Sergé, A., & Magee, A. I. (2010) · Journal of Cell Science · doi:10.1242/jcs.061739 · Cited by 126 · see citing works

Regulation of BCR signaling

Kurosaki, T. (2011) · Molecular Immunology · doi:10.1016/j.molimm.2010.12.007 · Cited by 114 · see citing works

The role of PLCγ2 in immunological disorders, cancer, and neurodegeneration

Jackson, J. T., Mulazzani, E., Nutt, S. L., & Masters, S. L. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.100905 · Cited by 113 · see citing works

Ibrutinib resistance in mantle cell lymphoma: clinical, molecular and treatment aspects

Hershkovitz‐Rokah, O., Pulver, D., Lenz, G., & Shpilberg, O. (2018) · British Journal of Haematology · doi:10.1111/bjh.15108 · Cited by 100 · see citing works

B Cell Receptor-Mediated Antigen Gathering Requires Ubiquitin Ligase Cbl and Adaptors Grb2 and Dok-3 to Recruit Dynein to the Signaling Microcluster

Schnyder, T., Castello, A., Feest, C., Harwood, N. E., Oellerich, T., Urlaub, H., Engelke, M., Wienands, J., Bruckbauer, A., & Batista, F. D. (2011) · Immunity · doi:10.1016/j.immuni.2011.06.001 · Cited by 96 · see citing works

Syk and Src Family Kinases Regulate C-type Lectin Receptor 2 (CLEC-2)-mediated Clustering of Podoplanin and Platelet Adhesion to Lymphatic Endothelial Cells

Pollitt, A. Y., Poulter, N. S., Gitz, E., Navarro‐Núñez, L., Wang, Y.-J., Hughes, C. E., Thomas, S. G., Nieswandt, B., Douglas, M. R., Owen, D. M., et al. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.584284 · Cited by 89 · see citing works

Immune Cell Inhibition by SLAMF7 Is Mediated by a Mechanism Requiring Src Kinases, CD45, and SHIP-1 That Is Defective in Multiple Myeloma Cells

Guo, H., Cruz‐Munoz, M., Wu, N., Robbins, M. D. H., & Veillette, A. (2014) · Molecular and Cellular Biology · doi:10.1128/mcb.01107-14 · Cited by 88 · see citing works

Autoinhibition and adapter function of Syk

Kulathu, Y., Grothe, G., & Reth, M. G. (2009) · Immunological Reviews · doi:10.1111/j.1600-065x.2009.00837.x · Cited by 87 · see citing works

The B‐cell antigen receptor signals through a preformed transducer module of SLP65 and CIN85

Oellerich, T., Bremes, V., Neumann, K., Bohnenberger, H., Dittmann, K., Hsiao, H., Engelke, M., Schnyder, T., Batista, F. D., Urlaub, H., et al. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.251 · Cited by 85 · see citing works

Toll-like receptor ligands sensitize B-cell receptor signalling by reducing actin-dependent spatial confinement of the receptor

Freeman, S. A., Jaumouillé, V., Choi, K., Hsu, B. E., Wong, H. S., Abraham, L., Graves, M. L., Coombs, D., Roskelley, C. D., Das, R., et al. (2015) · Nature Communications · doi:10.1038/ncomms7168 · Cited by 84 · see citing works

The Cytoskeleton Coordinates the Early Events of B-cell ActivationPreprint

Harwood, N. E., & Batista, F. D. (2010) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a002360 · Cited by 86 · see citing works

Cdc42 is a key regulator of B cell differentiation and is required for antiviral humoral immunity

Burbage, M., Keppler, S. J., Gasparrini, F., Martínez, N., Gaya, M., Feest, C., Domart, M., Brakebusch, C., Collinson, L., Bruckbauer, A., et al. (2014) · The Journal of Experimental Medicine · doi:10.1084/jem.20141143 · Cited by 83 · see citing works

Ligand Mobility Regulates B Cell Receptor Clustering and Signaling Activation

Ketchum, C. M., Miller, H. E., Song, W., & Upadhyaya, A. (2014) · Biophysical Journal · doi:10.1016/j.bpj.2013.10.043 · Cited by 80 · see citing works

Targeting B-cell receptor and PI3K signaling in diffuse large B-cell lymphoma

Xu, W., Berning, P., & Lenz, G. (2021) · Blood · doi:10.1182/blood.2020006784 · Cited by 84 · see citing works

A Balance of Bruton’s Tyrosine Kinase and SHIP Activation Regulates B Cell Receptor Cluster Formation by Controlling Actin Remodeling

Liu, C., Miller, H. E., Hui, K. L., Grooman, B., Bolland, S. M., Upadhyaya, A., & Song, W. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1100157 · Cited by 79 · see citing works

The role of microtubules in the immune system and as potential targets for gut-based immunotherapy

Ber, T. I., & Ilan, Y. (2019) · Molecular Immunology · doi:10.1016/j.molimm.2019.04.014 · Cited by 78 · see citing works

N-WASP Is Essential for the Negative Regulation of B Cell Receptor Signaling

Liu, C., Bai, X., Wu, J., Sharma, S., Upadhyaya, A., Dahlberg, C. I. M., Westerberg, L. S., Snapper, S. B., Zhao, X., & Song, W. (2013) · PLoS Biology · doi:10.1371/journal.pbio.1001704 · Cited by 76 · see citing works

Regulation of integrin activation through the B-cell receptor

Arana, E., Harwood, N. E., & Batista, F. D. (2008) · Journal of Cell Science · doi:10.1242/jcs.017905 · Cited by 74 · see citing works

The role of PTPN22 in the pathogenesis of autoimmune diseases: A comprehensive review

Tizaoui, K., Terrazzino, S., Cargnin, S., Lee, K. H., Gauckler, P., Li, H. J., Shin, J. I., & Kronbichler, A. (2021) · Seminars in Arthritis and Rheumatism · doi:10.1016/j.semarthrit.2021.03.004 · Cited by 72 · see citing works

Molecular basis for potent B cell responses to antigen displayed on particles of viral size

Brooks, J. F., Riggs, J. B., Mueller, J. L., Mathenge, R., Wholey, W.-Y., Meyer, A. R., Yoda, S.-T., Vykunta, V. S., Nielsen, H. V., Cheng, W., et al. (2023) · Nature Immunology · doi:10.1038/s41590-023-01597-9 · Cited by 72 · see citing works

The molecular assembly and organization of signaling active B‐cell receptor oligomers

Tolar, P., Sohn, H. W., Liu, W., & Pierce, S. K. (2009) · Immunological Reviews · doi:10.1111/j.1600-065x.2009.00833.x · Cited by 68 · see citing works

Nck-mediated recruitment of BCAP to the BCR regulates the PI(3)K-Akt pathway in B cells

Castello, A., Gaya, M., Tucholski, J., Oellerich, T., Lu, K., Tafuri, A., Pawson, T. J., Wienands, J., Engelke, M., & Batista, F. D. (2013) · Nature Immunology · doi:10.1038/ni.2685 · Cited by 72 · see citing works

The Coordination Between B Cell Receptor Signaling and the Actin Cytoskeleton During B Cell Activation

Li, J., Yin, W., Jing, Y., Kang, D., Yang, L., Cheng, J., Yu, Z., Peng, Z., Li, X., Wen, Y., et al. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2018.03096 · Cited by 70 · see citing works

Substrate stiffness governs the initiation of B cell activation by the concerted signaling of PKCβ and focal adhesion kinase

Shaheen, S., Wan, Z., Li, Z., Chau, A., Li, X., Zhang, S., Liu, Y., Yi, J., Zeng, Y., Wang, J., et al. (2017) · eLife · doi:10.7554/elife.23060 · Cited by 69 · see citing works

Role of Calcium Signaling in B Cell Activation and Biology

Baba, Y., & Kurosaki, T. (2015) · Current topics in microbiology and immunology · doi:10.1007/82_2015_477 · Cited by 66 · see citing works

The pivotal position of the actin cytoskeleton in the initiation and regulation of B cell receptor activation

Song, W., Liu, C., & Upadhyaya, A. (2013) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2013.07.016 · Cited by 69 · see citing works

Arp2/3 complex-driven spatial patterning of the BCR enhances immune synapse formation, BCR signaling and B cell activation

Bolger-Munro, M., Choi, K., Scurll, J., Abraham, L., Chappell, R. S., Sheen, D., Dang-Lawson, M., Wu, X., Priatel, J. J., Coombs, D., et al. (2019) · eLife · doi:10.7554/elife.44574 · Cited by 68 · see citing works

PI3Ks in Lymphocyte Signaling and Development

Okkenhaug, K., & Fruman, D. A. (2010) · Current topics in microbiology and immunology · doi:10.1007/82_2010_45 · Cited by 67 · see citing works

The central role of the cytoskeleton in mechanisms and functions of the NK cell immune synapse

Lagrue, K., Carisey, A. F., Oszmiana, A., Kennedy, P. R., Williamson, D. J., Cartwright, A. N. R., Barthen, C., & Davis, D. M. (2013) · Immunological Reviews · doi:10.1111/imr.12107 · Cited by 67 · see citing works

Complementary Phosphorylation Sites in the Adaptor Protein SLP-76 Promote Synergistic Activation of Natural Killer Cells

Kim, H. S., & Long, E. O. (2012) · Science Signaling · doi:10.1126/scisignal.2002754 · Cited by 66 · see citing works

Toll-like receptor 9 antagonizes antibody affinity maturation

Akkaya, M., Akkaya, B., Kim, A. S., Miozzo, P., Sohn, H., Pena, M., Roesler, A. S., Theall, B. P., Henke, T., Kabat, J., et al. (2018) · Nature Immunology · doi:10.1038/s41590-018-0052-z · Cited by 66 · see citing works

Actin Reorganization Is Required for the Formation of Polarized B Cell Receptor Signalosomes in Response to Both Soluble and Membrane-Associated Antigens

Liu, C., Miller, H. E., Orlowski, G. M., Hang, H., Upadhyaya, A., & Song, W. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1103065 · Cited by 65 · see citing works

CD23 can negatively regulate B-cell receptor signaling

Liu, C., Richard, K., Wiggins, M., Zhu, X., Conrad, D. H., & Song, W. (2016) · Scientific Reports · doi:10.1038/srep25629 · Cited by 65 · see citing works

One-way membrane trafficking of SOS in receptor-triggered Ras activation

Christensen, S. M., Tu, H., Jun, J. E., Alvarez, S. A., Triplet, M. G., Iwig, J. S., Yadav, K. K., Bar‐Sagi, D., Roose, J. P., & Groves, J. T. (2016) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.3275 · Cited by 61 · see citing works

Strategies to circumvent humoral immunity to adeno-associated viral vectors

Tse, L. V., Moller-Tank, S., & Asokan, A. (2015) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.2015.1035645 · Cited by 61 · see citing works

Essential Role of NADPH Oxidase–Dependent Production of Reactive Oxygen Species in Maintenance of Sustained B Cell Receptor Signaling and B Cell Proliferation

Feng, Y.-Y., Tang, M., Suzuki, M., Gunasekara, C. P., Anbe, Y., Hiraoka, Y., Liu, J., Grasberger, H., Ohkita, M., Matsumura, Y., et al. (2019) · The Journal of Immunology · doi:10.4049/jimmunol.1800443 · Cited by 58 · see citing works

Non-Covalent BTK Inhibitors—The New BTKids on the Block for B-Cell Malignancies

Lewis, K. L., & Cheah, C. Y. (2021) · Journal of Personalized Medicine · doi:10.3390/jpm11080764 · Cited by 57 · see citing works

Molecular Control of B Cell Activation and Immunological Synapse Formation

Kuokkanen, E., Šuštar, V., & Mattila, P. K. (2015) · Traffic · doi:10.1111/tra.12257 · Cited by 55 · see citing works

Swiprosin-1/EFhd2 Controls B Cell Receptor Signaling through the Assembly of the B Cell Receptor, Syk, and Phospholipase C γ2 in Membrane Rafts

Kroczek, C., Lang, C., Brachs, S., Grohmann, M., Dütting, S., Schweizer, A., Nitschke, L., Feller, S. M., Jäck, H., & Mielenz, D. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0903642 · Cited by 56 · see citing works

Visualizing a role for the actin cytoskeleton in the regulation of B‐cell activation

Batista, F. D., Treanor, B., & Harwood, N. E. (2010) · Immunological Reviews · doi:10.1111/j.1600-065x.2010.00943.x · Cited by 52 · see citing works

The B‐lymphoid Grb2 interaction code

Neumann, K., Oellerich, T., Urlaub, H., & Wienands, J. (2009) · Immunological Reviews · doi:10.1111/j.1600-065x.2009.00845.x · Cited by 53 · see citing works

Early Events of B Cell Activation by AntigenA presentation from the 12th Joint Meeting of the Signal Transduction Society, Weimar, Germany, 29 to 31 October 2008.

Depoil, D., Weber, M., Treanor, B., Fleire, S. J., Carrasco, Y. R., Harwood, N. E., & Batista, F. D. (2009) · Science Signaling · doi:10.1126/scisignal.263pt1 · Cited by 53 · see citing works

The Phospholipase Cγ2 Mutants R665W and L845F Identified in Ibrutinib-resistant Chronic Lymphocytic Leukemia Patients Are Hypersensitive to the Rho GTPase Rac2 Protein

Walliser, C., Hermkes, E., Schade, A., Wiese, S., Deinzer, J., Zapatka, M., Désiré, L., Mertens, D., Stilgenbauer, S., & Gierschik, P. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.746842 · Cited by 51 · see citing works

BANK1 and BLK Act through Phospholipase C Gamma 2 in B-Cell Signaling

Bernal-Quirós, M., Wu, Y., Alarcón-Riquelme, M. E., & Castillejo-López, C. (2013) · PLoS ONE · doi:10.1371/journal.pone.0059842 · Cited by 51 · see citing works

A Conformation-Induced Oligomerization Model for B cell Receptor Microclustering and Signaling

Tolar, P., & Pierce, S. K. (2009) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-03858-7_8 · Cited by 49 · see citing works

Murine Gammaherpesvirus M2 Protein Induction of IRF4 via the NFAT Pathway Leads to IL-10 Expression in B Cells

Rangaswamy, U. S., & Speck, S. H. (2014) · PLoS Pathogens · doi:10.1371/journal.ppat.1003858 · Cited by 50 · see citing works

Force Generation in B-Cell Synapses

Tolar, P., & Spillane, K. M. (2014) · Advances in immunology · doi:10.1016/b978-0-12-800266-7.00002-9 · Cited by 48 · see citing works

No receptor stands alone: IgG B-cell receptor intrinsic and extrinsic mechanisms contribute to antibody memory

Xu, Y., Xu, L., Zhao, M., Xu, C., Fan, Y., Pierce, S. K., & Liu, W. (2014) · Cell Research · doi:10.1038/cr.2014.65 · Cited by 49 · see citing works

It's All About Change: The Antigen-driven Initiation of B-Cell Receptor SignalingPreprint

Liu, W., Sohn, H. W., Tolar, P., & Pierce, S. K. (2010) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a002295 · Cited by 48 · see citing works

Molecular Mechanisms of B Cell Antigen Gathering and Endocytosis

Hoogeboom, R., & Tolar, P. (2015) · Current Topics in Microbiology and Immunology · doi:10.1007/82_2015_476 · Cited by 48 · see citing works

A fundamental role of mAbp1 in neutrophils: impact on β2 integrin–mediated phagocytosis and adhesion in vivo

Schymeinsky, J., Gerstl, R., Mannigel, I., Niedung, K., Frommhold, D., Panthel, K., Heesemann, J., Sixt, M., Quast, T., Kolanus, W., et al. (2009) · Blood · doi:10.1182/blood-2009-02-206169 · Cited by 46 · see citing works

Actin‐mediated feedback loops in B‐cell receptor signaling

Song, W., Liu, C., Seeley‐Fallen, M. K., Miller, H. E., Ketchum, C. M., & Upadhyaya, A. (2013) · Immunological Reviews · doi:10.1111/imr.12113 · Cited by 41 · see citing works

PI(4,5)P2 determines the threshold of mechanical force–induced B cell activation

Wan, Z., Xu, C., Chen, X., Xie, H., Li, Z., Wang, J., Ji, X., Chen, H., Ji, Q., Shaheen, S., et al. (2018) · The Journal of Cell Biology · doi:10.1083/jcb.201711055 · Cited by 41 · see citing works

Novel Pathways Revealed in Bursa of Fabricius Transcriptome in Response to Extraintestinal Pathogenic Escherichia coli (ExPEC) Infection

Sun, H., Liu, P., Nolan, L. K., & Lamont, S. J. (2015) · PLoS ONE · doi:10.1371/journal.pone.0142570 · Cited by 36 · see citing works

The autoinhibitory C-terminal SH2 domain of phospholipase C–γ2 stabilizes B cell receptor signalosome assembly

Wang, J., Sohn, H., Sun, G., Milner, J. D., & Pierce, S. K. (2014) · Science Signaling · doi:10.1126/scisignal.2005392 · Cited by 36 · see citing works

Antigen Receptor Nanoclusters: Small Units with Big Functions

Liu, W., Wang, H., & Xu, C. (2016) · Trends in Immunology · doi:10.1016/j.it.2016.07.007 · Cited by 36 · see citing works

Growth of B Cell Receptor Microclusters Is Regulated by PIP2 and PIP3 Equilibrium and Dock2 Recruitment and Activation

Wang, J., Xu, L., Shaheen, S., Liu, S., Zheng, W., Sun, X., Li, Z., & Liu, W. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.10.117 · Cited by 37 · see citing works

CXCR4- and BCR-triggered integrin activation in B-cell chronic lymphocytic leukemia cells depends on JAK2-activated Bruton’s tyrosine kinase

Montresor, A., Toffali, L., Rigo, A., Ferrarini, I., Vinante, F., & Laudanna, C. (2018) · Oncotarget · doi:10.18632/oncotarget.26212 · Cited by 35 · see citing works

Galectin-9 regulates the threshold of B cell activation and autoimmunity

Smith, L. K., Fawaz, K., & Treanor, B. (2021) · eLife · doi:10.7554/elife.64557 · Cited by 35 · see citing works

B cell receptor-induced Ca2+ mobilization mediates F-actin rearrangements and is indispensable for adhesion and spreading of B lymphocytes

Maus, M., Medgyesi, D., Kiss, E., Schneider, A. E., Enyedi, Á., Szilágyi, N., Matkó, J., & Sármay, G. (2013) · Journal of Leukocyte Biology · doi:10.1189/jlb.0312169 · Cited by 35 · see citing works

B Cell Activation Triggered by the Formation of the Small Receptor Cluster: A Computational Study

Hat, B., Kaźmierczak, B., & Tomasz Lipniacki, B. (2011) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1002197 · Cited by 31 · see citing works

The channel-kinase TRPM7 regulates antigen gathering and internalization in B cells

Krishnamoorthy, M., Wasim, L., Buhari, F. H. M., Zhao, T., Mahtani, T., Ho, J., Kang, S., Deason-Towne, F., Perraud, A., Schmitz, C., et al. (2018) · Science Signaling · doi:10.1126/scisignal.aah6692 · Cited by 33 · see citing works

HPK1 Associates with SKAP-HOM to Negatively Regulate Rap1-Mediated B-Lymphocyte Adhesion

Königsberger, S., Peckl‐Schmid, D., Zaborsky, N., Patzak, I. M., Kiefer, F., & Achatz, G. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012468 · Cited by 32 · see citing works

Antigen bivalency of antigen-presenting cell-targeted vaccines increases B cell responses

Hinke, D. M., Andersen, T. K., Gopalakrishnan, R. P., Skullerud, L. M., Werninghaus, I. C., Grødeland, G., Fossum, E., Braathen, R., & Bogen, B. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.110901 · Cited by 32 · see citing works

Organisation and dynamics of antigen receptors: implications for lymphocyte signalling

Treanor, B., & Batista, F. D. (2010) · Current Opinion in Immunology · doi:10.1016/j.coi.2010.03.009 · Cited by 31 · see citing works

Ca2+ and calpain control membrane expansion during rapid cell spreading of neutrophils

Dewitt, S., Francis, R. J., & Hallett, M. B. (2013) · Journal of Cell Science · doi:10.1242/jcs.124917 · Cited by 31 · see citing works

Subcellular topography modulates actin dynamics and signaling in B-cells

Ketchum, C. M., Sun, X., Suberi, A., Fourkas, J. T., Song, W., & Upadhyaya, A. (2018) · Molecular Biology of the Cell · doi:10.1091/mbc.e17-06-0422 · Cited by 29 · see citing works

The growth of B cell receptor microcluster is a universal response of B cells encountering antigens with different motion features

Wan, Z., & Liu, W. (2012) · Protein & Cell · doi:10.1007/s13238-012-2054-1 · Cited by 28 · see citing works

The Dok‐3/Grb2 adaptor module promotes inducible association of the lipid phosphatase SHIP with the BCR in a coreceptor‐independent manner

Manno, B., Oellerich, T., Schnyder, T., Corso, J., Lösing, M., Neumann, K., Urlaub, H., Batista, F. D., Engelke, M., & Wienands, J. (2016) · European Journal of Immunology · doi:10.1002/eji.201646431 · Cited by 26 · see citing works

A novel dual inhibitor of microtubule and Bruton's tyrosine kinase inhibits survival of multiple myeloma and osteoclastogenesis

Pandey, M. K., Gowda, K., Sung, S., Abraham, T., Budak-Alpdoǧan, T., Talamo, G., Dovat, S., & Amin, S. (2017) · Experimental Hematology · doi:10.1016/j.exphem.2017.06.003 · Cited by 26 · see citing works

Bidirectional feedback between BCR signaling and actin cytoskeletal dynamics

Bhanja, A., Rey‐Suarez, I., Song, W., & Upadhyaya, A. (2021) · FEBS Journal · doi:10.1111/febs.16074 · Cited by 25 · see citing works

A PIP 2 -derived amplification loop fuels the sustained initiation of B cell activation

Xu, C., Xie, H., Guo, X., Gong, H., Liu, L., Qi, H., Xu, C., & Liu, W. (2017) · Science Immunology · doi:10.1126/sciimmunol.aan0787 · Cited by 24 · see citing works

Microsignalosomes: spatially resolved receptor signalling

Treanor, B., Harwood, N. E., & Batista, F. D. (2009) · Biochemical Society Transactions · doi:10.1042/bst0371014 · Cited by 24 · see citing works

Visualizing the Molecular and Cellular Events Underlying the Initiation of B-Cell Activation

Harwood, N. E., & Batista, F. D. (2009) · Current topics in microbiology and immunology · doi:10.1007/978-3-540-93864-4_7 · Cited by 24 · see citing works

A spatiotemporal map of co-receptor signaling networks underlying B cell activation

Susa, K. J., Bradshaw, G. A., Eisert, R. J., Schilling, C. M., Kalocsay, M., Blacklow, S. C., & Kruse, A. C. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114332 · Cited by 23 · see citing works

Translating B-cell receptor signalling into cytoskeletal remodelling

Weber, M. (2009) · UCL Discovery (University College London)

Early Events of B Cell Activation by AntigenA presentation from the 12th Joint Meeting of the Signal Transduction Society, Weimar, Germany, 29 to 31 October 2008.

Depoil, D., Weber, M., Treanor, B., Fleire, S. J., Carrasco, Y. R., Harwood, N. E., & Batista, F. D. (2009) · Science Signaling · doi:10.1126/scisignal.263pt1 · Cited by 53 · see citing works

New Insights into the Early Molecular Events Underlying B Cell Activation

Harwood, N. E., & Batista, F. D. (2008) · Immunity · doi:10.1016/j.immuni.2008.04.007 · Cited by 158 · see citing works

BCR-induced actin rearrangement provides a driving force for the formation of surface BCR signalosomes (84.1)

Song, W., Liu, C., Miller, H. E., Orlowski, G. M., Sharma, S., Lam, H.-K., Grooman, B., & Upadhyaya, A. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.184.supp.84.1

Signalling mechanisms contributing to integrin activation and immunological synapse formation in B cells

Vehlow, A. (2007) · Doctoral thesis, UCL (University College London).