XPC: Its Product and Biological Roles
Abstract
The XPC protein is a component of a heterotrimeric complex that is essential for damage recognition in a nucleotide excision repair subpathway that operates throughout the genome. Biochemical analyses have revealed that the broad substrate specificity of this repair system is based on the structure-specific DNA binding properties of the XPC complex. Other subunits of this complex, including human Rad23p orthologs and centrin 2, play individual roles in enhancing the damage recognition activity of XPC. Physical interaction with UV-damaged DNA-binding protein is also important for the efficient recruitment of XPC to sites containing DNA damage, particularly UV-induced photolesions. Furthermore, recent studies have suggested that XPC may also be involved in base excision repair and possibly in other cellular functions that may be mediated by posttranslational modifications.
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XPC mutations are less severe than XPA mutations because XPC acts mainly in global genomic nucleotide excision repair.
“XPC mutations, though relatively frequent, are less severe since this protein is primarily involved in GG-NER 10,16.”
From Xeroderma Pigmentosa Group A (XPA), Nucleotide Excision Repair and Regulation by ATR in Response to Ultraviolet Irradiation (2017) · cites this paper as [16]
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A multistep damage recognition mechanism for global genomic nucleotide excision repair
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Self-citationNew functions of XPC in the protection of human skin cells from oxidative damage
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Oxidative DNA damage and nucleotide excision repair
Melis, J. P. M., van Steeg, H., & Luijten, M. (2013) · Antioxidants & Redox Signaling · doi:10.1089/ars.2012.5036 · Cited by 234 · see citing works
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- Authors
- Sugasawa, K.
- Affiliations
- Biosignal Research Center, Kobe University (JP)
- Corresponding author
- Sugasawa, Kaoru
- ORCID
- Sugasawa, Kaoru
- Venue
- Advances in Experimental Medicine and Biology
- Publisher
- Springer New York
- Published
- 2008-11-29
- Volume
- 637
- Pages
- 47-56
- ISSN
- 0065-2598 (ISSN-L)
- OpenAlex
- W103198556
- Cited by
- 36
- References
- 11
- Citations by year
- 2025: 2 · 2024: 1 · 2022: 1 · 2020: 1 · 2019: 3 · 2018: 3 · 2017: 2 · 2016: 1 · 2015: 2 · 2014: 4 · 2013: 3 · 2012: 2
- FWCI
- 4.69
- Type
- book chapter
- Language
- en
- Open access
- closed
- Locations
- Advances in experimental medicine and biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
- Keywords
- XPC protein, nucleotide excision repair, DNA damage recognition, centrin 2, base excision repair, post-translational modification, DNA repair
- MeSH terms
- DNA Repair, DNA-Binding Proteins, Humans, Xeroderma Pigmentosum
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