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Cited by 36Research on Leishmaniasis StudiesLeprosy Research and TreatmentTrypanosoma species research and implications

Leishmania invasion and phagosome biogenesis

Lodge, Robert, Descoteaux, Albert·2008·Subcellular Biochemistry
DOI 10.1007/978-0-387-78267-6_14
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Abstract

Whereas bacterial pathogens take over the control of their host cell actin cytoskeleton by delivering an array of protein effectors through specialized secretion systems, promastigotes of the protozoan parasite Leishmania donovani rely entirely upon a cell surface glycolipid to achieve this feat. Here, we review recent evidence that L. donovani promastigotes subvert host macrophage actin dynamics during the establishment of infection and we discuss the potential mechanisms involved.

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Crossref · 10.1007/978-0-387-78267-6_14

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  • Leishmania promastigotes cripple the microbicidal power of the phagosome, rendering it a propitious parasitophorous vacuole for the parasite.

    “Leishmania promastigotes are able to cripple the microbicidal power of the phagosome, rendering it a propitious parasitophorous vacuole (PV) for the parasite (105, 106).”

    From Macrophage Cytokines: Involvement in Immunity and Infectious Diseases (2014) · cites this paper as [106]

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Authors
Lodge, R., & Descoteaux, A.
Affiliations
Institut National de la Recherche Scientifique (CA)
Corresponding author
Descoteaux, Albert
ORCID
Venue
Subcellular Biochemistry
Publisher
Springer New York
Published
2008-12-04
Volume
47
Pages
174-181
ISSN
0306-0225 (ISSN-L)
DOI
10.1007/978-0-387-78267-6_14
OpenAlex
W2159245987
Cited by
36
References
1
Citations by year
2023: 3 · 2022: 3 · 2021: 3 · 2020: 1 · 2019: 2 · 2018: 1 · 2017: 1 · 2016: 2 · 2015: 1 · 2014: 2 · 2013: 4 · 2012: 4
FWCI
14.70
Type
book chapter
Language
en
Open access
closed
Locations
  • Sub-cellular biochemistry/Subcellular biochemistry (publishedVersion)
  • PubMed (publishedVersion)
  • EspaceINRS (National Institute for Scientific Research (Canada)) (submittedVersion)
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Research on Leishmaniasis Studies
  • Health Sciences › Medicine › Infectious Diseases › Leprosy Research and Treatment
  • Health Sciences › Medicine › Epidemiology › Trypanosoma species research and implications
Keywords
Leishmania donovani, promastigotes, host cell invasion, phagosome biogenesis, macrophages, actin cytoskeleton, glycolipids, host-pathogen interaction
MeSH terms
Actins, Animals, Glycosphingolipids, Humans, Leishmania donovani, Life Cycle Stages, Macrophages, Models, Biological, Phagocytosis, Phagosomes

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