Leishmania Promastigotes Induce Cytokine Secretion in Macrophages through the Degradation of Synaptotagmin XI
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Synaptotagmins (Syts) are type-I membrane proteins that regulate vesicle docking and fusion in processes such as exocytosis and phagocytosis. We recently discovered that Syt XI is a recycling endosome- and lysosome-associated protein that negatively regulates the secretion of TNF and IL-6. In this study, we show that Syt XI is directly degraded by the zinc metalloprotease GP63 and excluded from Leishmania parasitophorous vacuoles by the promastigotes surface glycolipid lipophosphoglycan. Infected macrophages were found to release TNF and IL-6 in a GP63-dependent manner. To demonstrate that cytokine release was dependent on GP63-mediated degradation of Syt XI, small interfering RNA-mediated knockdown of Syt XI before infection revealed that the effects of small interfering RNA knockdown and GP63 degradation were not cumulative. In mice, i.p. injection of GP63-expressing parasites led to an increase in TNF and IL-6 secretion and to an augmented influx of neutrophils and inflammatory monocytes to the inoculation site. Both of these cell types have been shown to be infection targets and aid in the establishment of infection. In sum, our data revealed that GP63 induces proinflammatory cytokine release and increases infiltration of inflammatory phagocytes. This study provides new insight on how Leishmania exploits the immune response to establish infection.
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Syt XI associates to recycling endosomes and lysosomes in macrophages.
“One such regulator is the recently characterized protein Syt XI, which associates to recycling endosomes and lysosomes in macrophages (11, 22).”
From Macrophage Cytokines: Involvement in Immunity and Infectious Diseases (2014) · cites this paper as [22]
Infection of macrophages with GP63+/+ or GP63−/− parasites revealed that Syt XI is degraded by GP63, leading to the release of TNF and IL-6.
“Infection of macrophages with GP63+/+ or GP63−/− parasites revealed that Syt XI is degraded by GP63, leading to the release of TNF and IL-6.”
From Macrophage Cytokines: Involvement in Immunity and Infectious Diseases (2014) · cites this paper as [22]
Intraperitoneal injection of GP63-expressing promastigotes induces TNF and IL-6 release 4 h after inoculation.
“To highlight the relevance of these findings in an in vivo setting, it was demonstrated that intraperitoneal injection of GP63-expressing promastigotes induces TNF and IL-6 release 4 h after inoculation.”
From Macrophage Cytokines: Involvement in Immunity and Infectious Diseases (2014) · cites this paper as [22]
Cytokine release by infected macrophages positively correlated with the GP63 content of different Leishmania species.
“Moreover, cytokine release by infected macrophages positively correlated with the GP63 content of different Leishmania species.”
From Macrophage Cytokines: Involvement in Immunity and Infectious Diseases (2014) · cites this paper as [22]
GP63 promotes the infiltration of neutrophils and inflammatory monocytes early during infection.
“Interestingly, it was observed that GP63 also promotes the infiltration of neutrophils and inflammatory monocytes early during infection.”
From Macrophage Cytokines: Involvement in Immunity and Infectious Diseases (2014) · cites this paper as [22]
Overall, the findings underline the importance of proinflammatory cytokines and phagocytes at the early stages of Leishmania infection.
“Overall, those findings underline the importance of proinflammatory cytokines and phagocytes at the early stages of Leishmania infection (22).”
From Macrophage Cytokines: Involvement in Immunity and Infectious Diseases (2014) · cites this paper as [22]
Cites
Leishmaniasis Worldwide and Global Estimates of Its Incidence
Alvar, J., Vélez, I. D., Bern, C., Herrero, M., Desjeux, P., Cano, J., Jannin, J., Boer, M. D., & the WHO Leishmaniasis Control Team (2012) · PLoS ONE · doi:10.1371/journal.pone.0035671 · Cited by 5,141 · see citing works
Antimicrobial mechanisms of phagocytes and bacterial evasion strategies
Flannagan, R. S., Cosío, G., & Grinstein, S. (2009) · Nature Reviews Microbiology · doi:10.1038/nrmicro2128 · Cited by 947 · see citing works
In Vivo Imaging Reveals an Essential Role for Neutrophils in Leishmaniasis Transmitted by Sand Flies
Peters, N. C., Egen, J. G., Secundino, N. F. C., Debrabant, A., Kimblin, N., Kamhawi, S., Lawyer, P. G., Fay, M. P., Germain, R. N., & Sacks, D. L. (2008) · Science · doi:10.1126/science.1159194 · Cited by 837 · see citing works
Belkaid, Y., Hoffmann, K. F., Mendez, S., Kamhawi, S., Udey, M. C., Wynn, T. A., & Sacks, D. L. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.194.10.1497 · Cited by 557 · see citing works
The role of IL-10 in promoting disease progression in Leishmaniasis
Kane, M. M., & Mosser, D. M. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.2.1141 · Cited by 514 · see citing works
THE LIPOPHOSPHOGLYCAN OF LEISHMANIA PARASITES
Turco, S. J., & Descoteaux, A. (1992) · Annual Review of Microbiology · doi:10.1146/annurev.mi.46.100192.000433 · Cited by 479 · see citing works
Self-citationCell Biology of Ca2+-Triggered Exocytosis
Pang, Z., & Südhof, T. (2010) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2010.05.001 · Cited by 367 · see citing works
Griffin, G. K., Newton, G., Tarrio, M. L., Bu, D.-X., Maganto-Garcia, E., Azcutia, V., Alcaide, P., Grabie, N., Luscinskas, F. W., Croce, K. J., et al. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1200385 · Cited by 364 · see citing works
A role for the phagosome in cytokine secretion
Murray, R. Z., Kay, J. G., Sangermani, D. G., & Stow, J. L. (2005) · Science · doi:10.1126/science.1120225 · Cited by 330 · see citing works
Inhibition of Phagolysosomal Biogenesis by the Leishmania Lipophosphoglycan
Desjardins, M., & Descoteaux, A. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.185.12.2061 · Cited by 289 · see citing works
Self-citation(1999) · PubMed · Cited by 277 · see citing works
Targeted gene deletion in Leishmania major identifies leishmanolysin (GP63) as a virulence factor
Joshi, P. B., Kelly, B. L., Kamhawi, S., Sacks, D. L., & McMaster, W. R. (2002) · Molecular and Biochemical Parasitology · doi:10.1016/s0166-6851(01)00432-7 · Cited by 257 · see citing works
Biswas, P., Delfanti, F., Bernasconi, S., Mengozzi, M., Cota, M., Polentarutti, N., Mantovani, A., Lazzarin, A., Sozzani, S., & Poli, G. (1998) · Blood · doi:10.1182/blood.v91.1.258 · Cited by 238 · see citing works
Leishmania virulence factors: focus on the metalloprotease GP63
Olivier, M., Atayde, V. D., Isnard, A., Hassani, K., & Shio, M. T. (2012) · Microbes and Infection · doi:10.1016/j.micinf.2012.05.014 · Cited by 225 · see citing works
Structure of the lipid moiety of the Leishmania donovani lipophosphoglycan.
Orlandi, P. A., & Turco, S. J. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)61124-x · Cited by 223 · see citing works
Self-citationGomez, M. A., Contreras, I., Hallé, M., Tremblay, M. L., McMaster, R. W., & Olivier, M. (2009) · Science Signaling · doi:10.1126/scisignal.2000213 · Cited by 206 · see citing works
Cytokine secretion in macrophages and other cells: Pathways and mediators
Stow, J. L., Low, P. C., Offenhäuser, C., & Sangermani, D. (2009) · Immunobiology · doi:10.1016/j.imbio.2008.11.005 · Cited by 205 · see citing works
Ghosh, J., Bose, M., Roy, S., & Bhattacharyya, S. N. (2013) · Cell Host & Microbe · doi:10.1016/j.chom.2013.02.005 · Cited by 191 · see citing works
Vieira, S., Lemos, H., Grespan, R., Napimoga, M., Dal‐Secco, D., Freitas, A., Cunha, T., Verri Jr, W., Souza‐Junior, D., Jamur, M., et al. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2009.00367.x · Cited by 178 · see citing works
Flandin, J., Chano, F., & Descoteaux, A. (2005) · European Journal of Immunology · doi:10.1002/eji.200535079 · Cited by 173 · see citing works
Self-citationJaramillo, M., Gomez, M. A., Larsson, O., Shio, M. T., Topisirovic, I., Contreras, I., Luxenburg, R., Rosenfeld, A., Colina, R., McMaster, R. W., et al. (2011) · Cell Host & Microbe · doi:10.1016/j.chom.2011.03.008 · Cited by 171 · see citing works
Leishmania donovani lipophosphoglycan blocks NADPH oxidase assembly at the phagosome membrane
Lodge, R., Diallo, T. O., & Descoteaux, A. (2006) · Cellular Microbiology · doi:10.1111/j.1462-5822.2006.00758.x · Cited by 169 · see citing works
Self-citationLeishmania promastigotes: building a safe niche within macrophages
Moradin, N., & Descoteaux, A. (2012) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2012.00121 · Cited by 157 · see citing works
Self-citationMatheoud, D., Moradin, N., Bellemare-Pelletier, A., Shio, M. T., Hong, W. J., Olivier, M., Gagnon, É., Desjardins, M., & Descoteaux, A. (2013) · Cell Host & Microbe · doi:10.1016/j.chom.2013.06.003 · Cited by 148 · see citing works
Self-citationContreras, I., Gómez, M. A., Nguyen, O., Shio, M. T., McMaster, R. W., & Olivier, M. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1001148 · Cited by 143 · see citing works
Vinet, A. F., Fukuda, M., Turco, S. J., & Descoteaux, A. (2009) · PLoS Pathogens · doi:10.1371/journal.ppat.1000628 · Cited by 138 · see citing works
Self-citationHallé, M., Gomez, M. A., Stuible, M., Shimizu, H., McMaster, W. R., Olivier, M., & Tremblay, M. L. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m805861200 · Cited by 138 · see citing works
Gonçalves, R., Zhang, X., Cohen, H. B., Debrabant, A., & Mosser, D. M. (2011) · The Journal of Experimental Medicine · doi:10.1084/jem.20101751 · Cited by 124 · see citing works
CPAF: A Chlamydial Protease in Search of an Authentic Substrate
Chen, A. L., Johnson, K. A., Lee, J. K., Sütterlin, C., & Tan, M. (2012) · PLoS Pathogens · doi:10.1371/journal.ppat.1002842 · Cited by 117 · see citing works
Tolson, D. L., Turco, S. J., Beecroft, R. P., & Pearson, T. W. (1989) · Molecular and Biochemical Parasitology · doi:10.1016/0166-6851(89)90113-8 · Cited by 117 · see citing works
Self-citationGueirard, P., Laplante, A., Rondeau, C., Milon, G., & Desjardins, M. (2007) · Cellular Microbiology · doi:10.1111/j.1462-5822.2007.01018.x · Cited by 116 · see citing works
Matte, C., & Olivier, M. (2002) · The Journal of Infectious Diseases · doi:10.1086/339260 · Cited by 113 · see citing works
Major Surface Protease of Trypanosomatids: One Size Fits All?
Yao, C. (2010) · Infection and Immunity · doi:10.1128/iai.00776-09 · Cited by 105 · see citing works
Fusion, fission, and secretion during phagocytosis
Huynh, K. K., Kay, J. G., Stow, J. L., & Grinstein, S. (2007) · Physiology · doi:10.1152/physiol.00028.2007 · Cited by 105 · see citing works
A Novel Alternatively Spliced Variant of Synaptotagmin VI Lacking a Transmembrane Domain
Fukuda, M., & Mikoshiba, K. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.44.31428 · Cited by 104 · see citing works
Self-citationJones, M. R., Quinton, L. J., Simms, B. T., Lupa, M. M., Kogan, M. S., & Mizgerd, J. P. (2006) · The Journal of Infectious Diseases · doi:10.1086/499312 · Cited by 104 · see citing works
Host Cell Signalling andLeishmaniaMechanisms of Evasion
Shio, M. T., Hassani, K., Isnard, A., Ralph, B., Contreras, I., Gómez, M. A., Abu‐Dayyeh, I., & Olivier, M. (2011) · Journal of Tropical Medicine · doi:10.1155/2012/819512 · Cited by 99 · see citing works
Subversion of membrane transport pathways by vacuolar pathogens
Alix, E., Mukherjee, S., & Roy, C. R. (2011) · The Journal of Cell Biology · doi:10.1083/jcb.201105019 · Cited by 93 · see citing works
Regulation of immunity and inflammation by mediators from macrophages.
(1976) · PubMed Central · Cited by 92 · see citing works
c-fos and tumor necrosis factor gene expression in Leishmania donovani-infected macrophages.
Descoteaux, A., & Matlashewski, G. (1989) · Molecular and Cellular Biology · doi:10.1128/mcb.9.11.5223 · Cited by 86 · see citing works
Self-citationIdentification of EPI64 as a GTPase-activating Protein Specific for Rab27A
Itoh, T., & Fukuda, M. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m603808200 · Cited by 84 · see citing works
Self-citationThe Exocytosis-Regulatory Protein Synaptotagmin VII Mediates Cell Invasion by Trypanosoma cruzi
Caler, E. V., Chakrabarti, S., Fowler, K. T., Rao, S. K., & Andrews, N. W. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.193.9.1097 · Cited by 77 · see citing works
Critical Role of IRF-5 in the Development of T helper 1 responses to Leishmania donovani infection
Paun, A., Bankoti, R., Joshi, T., Pitha, P. M., & Stäger, S. (2011) · PLoS Pathogens · doi:10.1371/journal.ppat.1001246 · Cited by 75 · see citing works
Self-citationLeishmania donovani lipophosphoglycan disrupts phagosome microdomains in J774 macrophages
Dermine, J.-F., Goyette, G., Houde, M., Turco, S. J., & Desjardins, M. (2005) · Cellular Microbiology · doi:10.1111/j.1462-5822.2005.00550.x · Cited by 71 · see citing works
Self-citationSuppression of LPS-induced inflammatory responses in macrophages infected with Leishmania
Lapara, N. J., & Kelly, B. L. (2010) · Journal of Inflammation · doi:10.1186/1476-9255-7-8 · Cited by 68 · see citing works
Functional aspects of the Leishmania donovani lipophosphoglycan during macrophage infection
Descoteaux, A., & Turco, S. J. (2002) · Microbes and Infection · doi:10.1016/s1286-4579(02)01624-6 · Cited by 65 · see citing works
Self-citationStimulation of human T lymphocytes by Leishmania lipophosphoglycan-associated proteins
Russo, D. M., Turco, S. J., Burns, J. M., & Reed, S. G. (1992) · The Journal of Immunology · doi:10.4049/jimmunol.148.1.202 · Cited by 65 · see citing works
Self-citationSite-Dependent Recruitment of Inflammatory Cells Determines the Effective Dose of Leishmania major
Ribeiro-Gomes, F. L., Roma, E. H., Carneiro, M. B. H., Doria, N. A., Sacks, D. L., & Peters, N. C. (2014) · Infection and Immunity · doi:10.1128/iai.01600-13 · Cited by 64 · see citing works
Leishmania donovani lipophosphoglycan inhibits phagosomal maturation via action on membrane rafts
Winberg, M. E., Holm, Å., Särndahl, E., Vinet, A. F., Descoteaux, A., Magnusson, K., Rasmusson, B. J., & Lerm, M. (2008) · Microbes and Infection · doi:10.1016/j.micinf.2008.11.007 · Cited by 64 · see citing works
Self-citationMacdonald, M., Morrison, C., & McMaster, W. R. (1995) · Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology · doi:10.1016/0167-4838(95)00155-5 · Cited by 56 · see citing works
<i>Leishmania major</i> parasite stage‐dependent host cell invasion and immune evasion
Wenzel, U. A., Bank, E., Florian, C., Förster, S., Zimara, N., Steinacker, J., Klinger, M., Reiling, N., Ritter, U., & van Zandbergen, G. (2012) · The FASEB Journal · doi:10.1096/fj.11-184895 · Cited by 52 · see citing works
Synaptotagmin XI regulates phagocytosis and cytokine secretion in macrophages
Arango Duque, G., Fukuda, M., & Descoteaux, A. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1202500 · Cited by 52 · see citing works
Self-citationThe Exocytosis Regulator Synaptotagmin V Controls Phagocytosis in Macrophages
Vinet, A. F., Fukuda, M., & Descoteaux, A. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.8.5289 · Cited by 42 · see citing works
Self-citationThe major surface protease (MSP or GP63) in the intracellular amastigote stage of Leishmania chagasi
Hsiao, C. C., Yao, C., Storlie, P., Donelson, J. E., & Wilson, M. E. (2007) · Molecular and Biochemical Parasitology · doi:10.1016/j.molbiopara.2007.10.008 · Cited by 42 · see citing works
Leishmania invasion and phagosome biogenesis
Lodge, R., & Descoteaux, A. (2008) · Subcellular Biochemistry · doi:10.1007/978-0-387-78267-6_14 · Cited by 36 · see citing works
Self-citationHost-parasite relationship in murine leishmaniasis: pathophysiological and immunological changes
Reiner, N. E. (1982) · Infection and Immunity · doi:10.1128/iai.38.3.1223-1230.1982 · Cited by 35 · see citing works
Rat and Drosophila Synaptotagmin 4 Have Opposite Effects during SNARE-catalyzed Membrane Fusion
Wang, Z., & Chapman, E. R. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.137745 · Cited by 32 · see citing works
Button, L. L., Wilson, G. M., Astell, C. R., & McMaster, W. R. (1993) · Gene · doi:10.1016/0378-1119(93)90176-4 · Cited by 32 · see citing works
Vinet, A. F., Jananji, S., Turco, S. J., Fukuda, M., & Descoteaux, A. (2011) · Microbiology · doi:10.1099/mic.0.050252-0 · Cited by 28 · see citing works
Self-citationKaram, M. C., Hamdan, H. G., Abi Chedid, N. A., Bodman-Smith, K. B., Eales-Reynolds, L.-J. E., & Baroody, G. M. (2006) · Experimental Parasitology · doi:10.1016/j.exppara.2006.01.003 · Cited by 21 · see citing works
Identification of a gp63 surface glycoprotein in Leishmania tarentolae
Campbell, D. A. (1992) · FEMS Microbiology Letters · doi:10.1016/0378-1097(92)90461-v · Cited by 15 · see citing works
Identification of a gp63 surface glycoprotein inLeishmania tarentolae
Campbell, D. A., Kurath, U., & Fleischmann, J. (1992) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.1992.tb05398.x · Cited by 14 · see citing works
Macrophages in the Regulation of Immunity
Huber, C., & Stingl, G. (1981) · Haematology and Blood Transfusion / Hämatologie und Bluttransfusion · doi:10.1007/978-3-642-81696-3_4 · Cited by 14 · see citing works
(1997) · PubMed · Cited by 14 · see citing works
Leishmania Dices Away Cholesterol for Survival
Descoteaux, A., Moradin, N., & Arango Duque, G. (2013) · Cell Host & Microbe · doi:10.1016/j.chom.2013.02.018 · Cited by 13 · see citing works
Self-citation
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Sorted by citations
Macrophage Cytokines: Involvement in Immunity and Infectious Diseases
Arango Duque, G., & Descoteaux, A. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00491 · Cited by 2,708 · see citing works
“hypothesized that Syt XI, a negative regulator of cytokine secretion (11), was targeted by Leishmania (Figure 2B) (22).”
BackgroundSelf-citationAtayde, V. D., Hassani, K., Filho, A. D. S. L., Borges, A. R., Adhikari, A., Martel, C., & Olivier, M. (2016) · Cellular Immunology · doi:10.1016/j.cellimm.2016.07.013 · Cited by 138 · see citing works
Leishmania survival in the macrophage: where the ends justify the means
Duque, G. A., & Descoteaux, A. (2015) · Current Opinion in Microbiology · doi:10.1016/j.mib.2015.04.007 · Cited by 108 · see citing works
Self-citationFernandes, M. C., Dillon, L. A. L., Belew, A. T., Bravo, H. C., Mosser, D. M., & El-Sayed, N. M. (2016) · mBio · doi:10.1128/mbio.00027-16 · Cited by 99 · see citing works
Chauhan, P. S., Nair, A., Patidar, A., Dandapat, J., Sarkar, A., & Saha, B. (2021) · Cytokine · doi:10.1016/j.cyto.2021.155458 · Cited by 89 · see citing works
Leishmania major Promastigotes Evade LC3-Associated Phagocytosis through the Action of GP63
Matte, C., Casgrain, P.-A., Séguin, O., Moradin, N., Hong, W. J., & Descoteaux, A. (2016) · PLoS Pathogens · doi:10.1371/journal.ppat.1005690 · Cited by 69 · see citing works
Self-citationHammami, A., Charpentier, T., Smans, M., & Stäger, S. (2015) · PLoS Pathogens · doi:10.1371/journal.ppat.1004938 · Cited by 62 · see citing works
Self-citationFilho, A. D. S. L., Fajardo, E. F., Chang, K. P., Clément, P., & Olivier, M. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.709258 · Cited by 58 · see citing works
Casgrain, P.-A., Martel, C., McMaster, W. R., Mottram, J. C., Olivier, M., & Descoteaux, A. (2016) · PLoS Pathogens · doi:10.1371/journal.ppat.1005658 · Cited by 57 · see citing works
Self-citationLeishmania hijacking of the macrophage intracellular compartments
Moal, V. L.-L., & Loiseau, P. M. (2015) · FEBS Journal · doi:10.1111/febs.13601 · Cited by 56 · see citing works
Leishmania, the phagosome, and host responses: The journey of a parasite
Séguin, O., & Descoteaux, A. (2016) · Cellular Immunology · doi:10.1016/j.cellimm.2016.08.004 · Cited by 54 · see citing works
Self-citationSynaptotagmin‐11 inhibits cytokine secretion and phagocytosis in microglia
Du, C., Wang, Y., Zhang, F., Yan, S., Guan, Y., Gong, X., Zhang, T., Cui, X., Wang, X., & Zhang, C. X. (2017) · Glia · doi:10.1002/glia.23186 · Cited by 43 · see citing works
Dong, G., Wagner, V., Minguez-Menendez, A., Fernandez‐Prada, C., & Olivier, M. (2021) · Molecular Immunology · doi:10.1016/j.molimm.2021.04.003 · Cited by 41 · see citing works
Duque, G. A., Jardim, A., Gagnon, É., Fukuda, M., & Descoteaux, A. (2019) · PLoS Pathogens · doi:10.1371/journal.ppat.1007982 · Cited by 41 · see citing works
Self-citationAnti-Leishmanial Vaccines: Assumptions, Approaches, and Annulments
Zutshi, S., Kumar, S., Chauhan, P. S., Bansode, Y. D., Nair, A., Roy, S., Sarkar, A., & Saha, B. (2019) · Vaccines · doi:10.3390/vaccines7040156 · Cited by 41 · see citing works
IRF-5 Promotes Cell Death in CD4 T Cells during Chronic Infection
Fabié, A., Mai, L. T., Dagenais-Lussier, X., Hammami, A., van Grevenynghe, J., & Stäger, S. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.06.107 · Cited by 40 · see citing works
Self-citationRevisiting Leishmania GP63 host cell targets reveals a limited spectrum of substrates
Guay-Vincent, M.-M., Matte, C., Berthiaume, A.-M., Olivier, M., Jaramillo, M., & Descoteaux, A. (2022) · PLoS Pathogens · doi:10.1371/journal.ppat.1010640 · Cited by 38 · see citing works
Self-citationGao, X., He, D., Liu, D., Hu, G., Zhang, Y., Meng, T., Su, Y., Zhou, A., Huang, B., Du, J., et al. (2020) · Immunobiology · doi:10.1016/j.imbio.2020.151965 · Cited by 33 · see citing works
Gene family phylogeny and the evolution of parasite cell surfaces
Jackson, A. P. (2016) · Molecular and Biochemical Parasitology · doi:10.1016/j.molbiopara.2016.03.007 · Cited by 30 · see citing works
Schapovalova, O., Вячеславовна, Г. А., de Munter, J., Sheveleva, E., MIu, E., Gorbunov, N., Sicker, M., Umriukhin, A., Lyubchyk, S., Lesch, K., et al. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.952977 · Cited by 28 · see citing works
Chaparro, V., Graber, T. E., Alain, T., & Jaramillo, M. (2022) · Scientific Reports · doi:10.1038/s41598-022-10317-6 · Cited by 21 · see citing works
Matte, C., & Descoteaux, A. (2016) · PLoS Pathogens · doi:10.1371/journal.ppat.1005962 · Cited by 22 · see citing works
Self-citationLeishmania braziliensis: Strain-Specific Modulation of Phagosome Maturation
Vieira, T. D. S., Duque, G. A., Ory, K., Gontijo, C. M. F., Soares, R. P., & Descoteaux, A. (2019) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2019.00319 · Cited by 22 · see citing works
Self-citationDemarchi, I. G., Monich, M. D. S. T., Thomazella, M. V., Mota, C. A., Gazim, Z. C., Cortez, D. A. G., Aristides, S. M. A., Silveira, T. G. V., & Lonardoni, M. V. C. (2015) · Parasite Immunology · doi:10.1111/pim.12297 · Cited by 20 · see citing works
Iron acquisition inLeishmaniaand its crucial role in infection
NIU, Q., Li, S., Chen, D., CHEN, Q., & Chen, J. (2016) · Parasitology · doi:10.1017/s0031182016000858 · Cited by 17 · see citing works
Selvakumar, B., Sekar, P., & Samsudin, A. R. (2024) · Journal of Leukocyte Biology · doi:10.1093/jleuko/qiad165 · Cited by 16 · see citing works
Yan, S., Wang, Y., Zhang, Y., Wang, L., Zhao, X., Du, C., Gao, P., Yan, F., Liu, F., Gong, X., et al. (2019) · The FASEB Journal · doi:10.1096/fj.201901715r · Cited by 16 · see citing works
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Anand, S., & Madhubala, R. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.727107 · Cited by 16 · see citing works
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Bonam, S. R., Bhunia, D., Muller, S., Nerella, S. G., Alvala, M., & Halmuthur, M. S. K. (2019) · International Immunopharmacology · doi:10.1016/j.intimp.2019.105684 · Cited by 14 · see citing works
de Celis, H. Á., Gómez, C. P., Descoteaux, A., & Duplay, P. (2014) · Microbes and Infection · doi:10.1016/j.micinf.2014.12.011 · Cited by 14 · see citing works
Self-citationDuque, G. A., Dion, R., Matte, C., Fabié, A., Descoteaux, J., Stäger, S., & Descoteaux, A. (2021) · The Journal of Immunology · doi:10.4049/jimmunol.2100258 · Cited by 11 · see citing works
Self-citationMonich, M. D. S. T., Demarchi, I. G., da Silva, P. R. F., Milaré, Á. C. F. H. R., Gazim, Z. C., Silveira, T. G. V., & Lonardoni, M. V. C. (2018) · Parasitology Research · doi:10.1007/s00436-018-6166-2 · Cited by 10 · see citing works
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Antonia, A. L., Barnes, A. B., Martin, A. T., Wang, L., & Ko, D. C. (2021) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0009224 · Cited by 10 · see citing works
Séguin, O., Mai, L. T., Ospina, H. A., Guay-Vincent, M.-M., Whiteheart, S. W., Stäger, S., & Descoteaux, A. (2022) · Infection and Immunity · doi:10.1128/iai.00183-21 · Cited by 9 · see citing works
Self-citationEbrahimi, S., Kalantari, M., Alipour, H., Azizi, K., Asgari, Q., & Bahreini, M. S. (2021) · Microbial Pathogenesis · doi:10.1016/j.micpath.2021.105281 · Cited by 8 · see citing works
Domeneghetti, L., Demarchi, I. G., Caitano, J. Z., Pedroso, R. B., Silveira, T. G. V., & Lonardoni, M. V. C. (2018) · Mediators of Inflammation · doi:10.1155/2018/6148351 · Cited by 7 · see citing works
Samanta, S., Banerjee, S., & Datta, R. (2025) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2025.110851 · Cited by 6 · see citing works
Samanta, S., Datta, R., & Maiti, S. (2025) · ACS Infectious Diseases · doi:10.1021/acsinfecdis.5c00531 · Cited by 4 · see citing works
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Wang, Y., & Zhang, C. X. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2506-0 · Cited by 4 · see citing works
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Descoteaux, A. (2017) · Royal Society of Chemistry eBooks · doi:10.1039/9781788010177-00387 · Cited by 4 · see citing works
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Zayats, R., Uzonna, J. E., & Murooka, T. T. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.671582 · Cited by 4 · see citing works
Mirzaei, M., Sharifi, I., Mohammad-Rafi, F., Anjomshoa, M., Abiri, A., Moqaddari, A. H., Nooshadokht, M., Raiesi, O., & Amirheidari, B. (2023) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2023.112245 · Cited by 3 · see citing works
Riguetti, L. D. M. A., Alves, C. R., & Souza‐Silva, F. (2026) · Protist · doi:10.1016/j.protis.2026.126145 · Cited by 1 · see citing works
Tandon, S., Muthuswami, R., & Madhubala, R. (2021) · Acta Tropica · doi:10.1016/j.actatropica.2021.106128
VAPA mediates lipid exchange between Leishmania amazonensis and host macrophagesPreprint
Gdovinova, I., & Descoteaux, A. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.10.03.616432
Self-citationSamanta, S., Banerjee, S., & Datta, R. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.04.16.649108
Role of Transcription Factor NR1H3 in the Pathogenesis of Tuberculosis
Kumari, A., & Kaur, R. (2025) · Biology Bulletin Reviews · doi:10.1134/s2079086425600146
- Authors
- Arango Duque, G., Fukuda, M., Turco, S. J., Stäger, S., & Descoteaux, A.
- Affiliations
- Institut National de la Recherche Scientifique–Institut Armand-Frappier , Laval, Quebec H7V 1B7 ,
- Tohoku University (JP)
- University of Kentucky (US)
- Institut National de la Recherche Scientifique (CA)
- Corresponding author
- Descoteaux, Albert
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2014-09-01
- Volume
- 193
- Issue
- 5
- Pages
- 2363-2372
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2130082930
- Cited by
- 48
- References
- 65
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 2 · 2023: 1 · 2022: 5 · 2021: 7 · 2020: 1 · 2019: 5 · 2018: 3 · 2017: 3 · 2016: 9 · 2015: 4 · 2014: 2
- FWCI
- 5.97
- Type
- journal article
- Language
- en
- Open access
- green
- hal.science
- Locations
- The Journal of Immunology (publishedVersion)
- PubMed (publishedVersion)
- EspaceINRS (National Institute for Scientific Research (Canada)) (acceptedVersion)
- HAL (submittedVersion, cc-by)
- HAL (submittedVersion)
- Funders
- Canadian Institutes of Health Research (125990_1, 123293_1)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Research on Leishmaniasis Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Health Sciences › Medicine › Infectious Diseases › Leprosy Research and Treatment
- Keywords
- Leishmania promastigotes, gp63, zinc metalloprotease, macrophages, cytokine production, TNF-α, interleukin-6, lipophosphoglycan, parasitophorous vacuole, vesicle fusion, inflammatory monocytes, neutrophils, host-parasite interactions, leishmaniasis
- MeSH terms
- Animals, Cell Line, Female, Cricetinae, Leishmania, Leishmaniasis, Metalloendopeptidases, Mice, Inbred BALB C, Monocytes, Tumor Necrosis Factor-alpha, Interleukin-6, Macrophages, Peritoneal, Synaptotagmins, Mice
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