In Vivo Skin Colonization and Decolonization Models for Candida auris
Abstract
Candida auris infections present a critical problem to the healthcare system in many parts of the world. This yeast clinically manifests as a disseminated candidiasis which can be life-threating for susceptible individuals, as well as cutaneous and wound infections. Moreover, C. auris can colonize the skin and act as a nidus of infection. Importantly, this emerging yeast unlike other Candida spp. has demonstrated multidrug resistance; thus its eradication can be challenging. Animal models are important to gain insight into the pathogenesis of this infection, as well as play a significant role in drug development. In this chapter, we describe two C. auris animal models: a cutaneous infection guinea pig model and a skin decolonization mouse model.
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The murine skin model is widely used to study disease pathogenesis and C. auris-host interactions.
“In addition, understanding the skin immune responses against C. auris is critical, as the murine skin model is widely used to study disease pathogenesis and C. auris-host interactions [4, 16–20].”
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Native human and mouse skin infection models to study Candida auris-host interactions
Seiser, S., Arzani, H., Ayub, T., Phan-Canh, T., Staud, C., Worda, C., Kuchler, K., & Elbe-Bürger, A. (2024) · Microbes and Infection · doi:10.1016/j.micinf.2023.105234 · Cited by 29 · see citing works
Balakumar, A., Das, D., Datta, A., Mishra, A., Bryak, G., Ganesh, S. M., Netea, M. G., Kumar, V., Lionakis, M. S., Arora, D., et al. (2024) · PLOS Pathogens · doi:10.1371/journal.ppat.1012699 · Cited by 25 · see citing works
- Authors
- Herrada, J., Gamal, A., Long, L., & Ghannoum, M. A.
- Affiliations
- University Hospitals Cleveland Medical Center (US)
- Corresponding author
- Ghannoum, Mahmoud A.
- Venue
- Methods in Molecular Biology
- Publisher
- Springer US
- Published
- 2022
- Volume
- 2517
- Pages
- 269-285
- ISSN
- 1064-3745 (ISSN-L)
- 1940-6029
- OpenAlex
- W4285268990
- Cited by
- 7
- References
- 0
- Citations by year
- 2026: 1 · 2024: 2 · 2023: 2 · 2022: 2
- FWCI
- 10.33
- Type
- book chapter
- Language
- en
- Open access
- closed
- Locations
- Methods in molecular biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Yeasts and Rust Fungi Studies
- Keywords
- Candida auris, skin colonization, animal models, cutaneous candidiasis, systemic candidiasis, guinea pig model, mouse model, multidrug resistance, antifungal drug development, pathogenesis
- MeSH terms
- Candida auris, Animals, Antifungal Agents, Candida, Candidiasis, Disease Models, Animal, Guinea Pigs, Saccharomyces cerevisiae, Mice
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