The DOI matches its Crossref record; 67 of the 67 references it cites were found in a registry or an index.
Regulation of Liver Growth: Protooncogenes and Transforming Growth Factors
Abstract
After the fetal and postnatal growth of the liver, hepatocytes no longer proliferate actively. In adult humans and animals, hepatocytes have long life spans, ranging from 200 to 400 days or more (in the normal adult liver about 1 hepatocyte in 10,000 to 20,000 may be replicating at any one time), but it is a common observation that they divide in response to hepatic cell death or loss of liver tissue (7). Hepatocyte proliferation occurs in viral hepatitis, cirrhosis, hepatotoxic reactions, and massive liver necrosis as well as other conditions. It can be induced in experimental animals by partial hepatectomy or cell death caused by chemical agents such as carbon tetrachloride and dioxins (73, 83). In all of these cases, hepatic growth is a compensatory response to decreased liver mass or loss of cells but it is also possible to induce DNA synthesis and replication of normal liver hepatocytes. This adaptive response occurs in some types of nutritional changes and may be caused by agents such as hexachlorobenzene and organochlorine insecticides that cause minimal hepatocyte necrosis (8, 68, 72). These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Cites
Experimental pathology of the liver
Higgins, G. (1931) · Medical Entomology and Zoology · Cited by 4,056
Higgins, G. (1931) · Cited by 2,444
Aaronson, S. A. (1991) · Science · doi:10.1126/science.1659742 · Cited by 2,028
Transforming growth factor beta
(2011) · SpringerReference · doi:10.1007/springerreference_39918 · Cited by 1,944
Kehrl, J. H., Wakefield, L. M., Roberts, A. B., Jakowlew, S., Alvarez-Mon, M., Derynck, R., Sporn, M. B., & Fauci, A. S. (1986) · The Journal of experimental medicine · doi:10.1084/jem.163.5.1037 · Cited by 1,582
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Nakamura, T., Teramoto, H., & Ichihara, A. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.17.6489 · Cited by 582
Mead, J. E., & Fausto, N. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.5.1558 · Cited by 526
Self-citationCell adhesion protein receptors as targets for transforming growth factor-$beta; action
IGNOTZ, R. (1987) · Cell · doi:10.1016/0092-8674(87)90146-2 · Cited by 485
Cited by
Yamada, Y., Kirillova, I., Peschon, J. J., & Fausto, N. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.4.1441 · Cited by 944
Self-citationJhappan, C., Stahle, C., Harkins, R. N., Fausto, N., Smith, G. H., & Merlino, G. T. (1990) · Cell · doi:10.1016/0092-8674(90)90076-q · Cited by 710
Self-citationRapid activation of the stat3 transcription complex in liver regeneration
Cressman, D. E., Diamond, R. H., & Taub, R. (1995) · Hepatology · doi:10.1002/hep.1840210531 · Cited by 314
Phase 2 study of erlotinib in patients with unresectable hepatocellular carcinoma
Thomas, M. B., Chadha, R., Glover, K., Wang, X., Morris, J., Brown, T., Rashid, A., Dancey, J., & Abbruzzese, J. L. (2007) · Cancer · doi:10.1002/cncr.22886 · Cited by 306
PRL-1, a unique nuclear protein tyrosine phosphatase, affects cell growth.
Diamond, R. H., Cressman, D. E., Laz, T. M., Abrams, C. S., & Taub, R. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.6.3752 · Cited by 265
Metadata
- Authors
- Fausto, N., & Mead, J. E.
- Venue
- Pathology Reviews • 1990
- Publisher
- Humana Press
- Published
- 1990
- Volume
- 60
- Issue
- 1
- Pages
- 3-12
- OpenAlex
- W2109926758
- Cited by
- 309
- References
- 67
- FWCI
- 80.06
- Type
- book chapter
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
