The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Growth Factors and Cancer
Abstract
Signaling pathways that mediate the normal functions of growth factors are commonly subverted in cancer. Oncogenes identified by a variety of approaches have been shown to function at critical steps in mitogenic signaling. Progression through the cell cycle requires the coordinated actions of members of two complementary classes of growth factors, and oncogenes appear to replace the actions of one set of these growth factors. Growth factors can also influence normal cell differentiation, and constitutive activation of growth-promoting pathways in cancer cells can modulate the cell phenotype as well. Paracrine actions of growth factors and cytokines may also influence the stepwise series of genetic events that lead to malignancy. New approaches for cancer therapy are being developed that intervene at various steps in growth factor signaling pathways.
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Citations
Cites
A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma
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Metcalf, D. (1989) · Nature · doi:10.1038/339027a0 · Cited by 1,023
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Cited by
Reactive oxygen species in cancer
Liou, G.-Y., & Storz, P. (2010) · Free Radical Research · doi:10.3109/10715761003667554 · Cited by 3,382
Cobleigh, M. A., Vogel, C. L., Tripathy, D., Robert, N. J., Scholl, S., Fehrenbacher, L., Wolter, J. M., Paton, V., Shak, S., Lieberman, G., et al. (1999) · Journal of Clinical Oncology · doi:10.1200/jco.1999.17.9.2639 · Cited by 2,765
G 1 Events and Regulation of Cell Proliferation
Pardee, A. B. (1989) · Science · doi:10.1126/science.2683075 · Cited by 2,182
Saltz, L. B., Meropol, N. J., Loehrer, P. J., Needle, M. N., Kopit, J., & Mayer, R. J. (2004) · Journal of Clinical Oncology · doi:10.1200/jco.2004.10.182 · Cited by 1,694
Emergent Properties of Networks of Biological Signaling Pathways
Bhalla, U. S., & Iyengar, R. (1999) · Science · doi:10.1126/science.283.5400.381 · Cited by 1,686
Metadata
- Authors
- Aaronson, S. A.
- Venue
- Science
- Published
- 1991-11-22
- Volume
- 254
- Issue
- 5035
- Pages
- 1146-1153
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2057409901
- Cited by
- 2,028
- References
- 3
- FWCI
- 57.97
- Type
- journal article
- Language
- en
- Open access
- closed
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- Aaronson, S. A. (1991). Growth Factors and Cancer. Science. https://doi.org/10.1126/science.1659742
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
