Cancer Targeted Drug Delivery: An Elusive Dream
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In tumors, inadequate lymphatic clearance causes fluid retention, elevating IFP and suppressing convective transport.
“In tumors, however, inadequate lymphatic clearance causes fluid retention, elevating IFP and suppressing convective transport [99,153].”
From Modeling Tumor Microenvironment Complexity In Vitro: Spheroids as Physiologically Relevant Tumor Models and Strategies for Their Analysis (2025) · cites this paper as [153]
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“So, there has been great concern about finding new types of drugs to combat cancer especially given the ever-increasing number of cases of resistance to existing anticancer drugs [7].”
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“However, the degree of EPR effect can vary from one tumor to another, or even spatially and temporally within the same tumor [21].”
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“enhanced permeability and retention (EPR) effect [24] that is often weak in human tumors [25–27].”
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- Authors
- Bae, Y. H., Park, K., & Mrsny, R. J.
- Affiliations
- University of Bath (GB)
- Purdue University West Lafayette (US)
- Venue
- Springer eBooks
- Publisher
- Springer New York
- Published
- 2013
- OpenAlex
- W394367630
- Cited by
- 67
- References
- 0
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 1 · 2023: 1 · 2022: 6 · 2021: 6 · 2020: 4 · 2019: 5 · 2018: 8 · 2017: 7 · 2016: 11 · 2015: 6 · 2014: 7 · 2013: 1
- FWCI
- 3.11
- Type
- book
- Language
- en
- Open access
- closed
- Licence
- Locations
- Springer eBooks (publishedVersion)
- Digital Access to Libraries (Université catholique de Louvain (UCL), l'Université de Namur (UNamur) and the Université Saint-Louis (USL-B)) (submittedVersion)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Keywords
- targeted drug delivery, cancer therapy, nanoparticle drug delivery, translational research, anticancer efficacy, tumor biology, drug delivery systems, tumor targeting, clinical translation
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