5α-Reductase-2 Deficiency and Complete Androgen Insensitivity: Lessons from Nature
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Androgens have a central role in acne.
“Androgens have a central role in acne, since acne onset is correlated with adrenarchal rise of blood DHEA-S levels [194], it manifests in congenital adrenal hyperplasia [195], is seen during hyperadrogenism in women [196], and it develops during anabolic steroid administration [197].”
From Steroidogenesis in the skin: Implications for local immune functions (2013) · cites this paper as [196]
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Paternity by Intrauterine Insemination with Sperm from a Man with 5α-Reductase-2 Deficiency
Katz, M. D., Kligman, I., Cai, L.-Q., Zhu, Y.-S., Fratianni, C. M., Zervoudakis, I., Rosenwaks, Z., & Imperato-McGinley, J. (1997) · New England Journal of Medicine · doi:10.1056/nejm199704033361404 · Cited by 131 · see citing works
Self-citationFamilial male pseudohermaphroditism due to 5-alpha-reductase deficiency in a Turkish village
Akgun, S., Ertel, N. H., Imperato-Mcginley, J., Sayli, B. S., & Shackleton, C. (1986) · The American Journal of Medicine · doi:10.1016/0002-9343(86)90262-7 · Cited by 57 · see citing works
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Steroidogenesis in the skin: Implications for local immune functions
Slominski, A., Zbytek, B., Nikolakis, G., Manna, P. R., Skobowiat, C., Zmijewski, M., Li, W., Janjetovic, Z., Postlethwaite, A., Zouboulis, C. C., et al. (2013) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2013.02.006 · Cited by 369 · see citing works
Skin steroidogenesis in health and disease
Nikolakis, G., Stratakis, C. A., Kanaki, T., Slominski, A., & Zouboulis, C. C. (2016) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-016-9390-z · Cited by 76 · see citing works
5α-Reductases in human physiology: an unfolding story
Traish, A. M. (2012) · Endocrine Practice · doi:10.4158/ep12108.ra · Cited by 57 · see citing works
- Authors
- Imperato-McGinley, J.
- Venue
- Advances in Experimental Medicine and Biology
- Publisher
- Springer US
- Published
- 2002
- Volume
- 511
- Pages
- 121-134
- ISSN
- 0065-2598 (ISSN-L)
- OpenAlex
- W1532982202
- Cited by
- 58
- References
- 2
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 3 · 2023: 4 · 2022: 2 · 2021: 4 · 2020: 2 · 2019: 3 · 2018: 3 · 2017: 1 · 2016: 2 · 2015: 2 · 2014: 1 · 2013: 2 · 2012: 1
- FWCI
- 1.43
- Type
- book chapter
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Advances in experimental medicine and biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Keywords
- complete androgen insensitivity syndrome, dihydrotestosterone, testosterone, 46,XY disorders of sex development, male sexual differentiation, androgen receptor, gender identity, androgens
- MeSH terms
- Cognition, Female, Gender Identity, Humans, Isoenzymes, Male, Phenotype, Sexual Behavior, Dihydrotestosterone, Androgen-Insensitivity Syndrome, Testosterone, 3-Oxo-5-alpha-Steroid 4-Dehydrogenase
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