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Cited by 76Dermatology and Skin DiseasesAdrenal Hormones and DisordersSteroid Chemistry and Biochemistry

The DOI matches its Crossref record; 160 of the 160 references it cites were found in a registry or an index.

Skin steroidogenesis in health and disease

Nikolakis, Georgios, Stratakis, Constantine A., Kanaki, Theodora, Slominski, Andrej, Zouboulis, Christos C.·2016·Reviews in Endocrine and Metabolic Disorders
DOI 10.1007/s11154-016-9390-z
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Abstract

The skin is an important extra-gonadal steroidogenic organ, capable of metabolizing various hormones from their precursors, as well as of synthesizing de novo a broad palette of sex steroids and glucocorticoids from cholesterol. In this manuscript, we review the major steroidogenic properties of human skin and we suggest steroidogenesis' impairment as a cardinal factor for various pathological conditions such as acne, rosacea, atopic dermatitis, and androgenic alopecia.

Overview

Integrity signals

Registry

Crossref · 10.1007/s11154-016-9390-z

Cites

160 of 160 references verified0 citation errors · 0 not checkable

Statistics

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Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Acne-prone skin expresses higher levels of androgen generating enzymes than non-acne-prone skin, including HSD17B3 and AKR1C3 converting A4 to T, STS and SRD5A1.

    “Acne-prone skin expresses higher levels of androgen generating enzymes than non-acne-prone skin (HSD17B3 and AKR1C3 converting A4 to T, STS and SRD5A1; summarized in (Nikolakis et al., 2016)).”

    From Intracrine androgen biosynthesis, metabolism and action revisited (2018) · cites this paper as Nikolakis et al., 2016

  • Circulating DHEA can be used as a precursor to produce active androgens by 3βHSD, 5α-reductase and reductive 17βHSD activity in the skin.

    “Circulating DHEA can also be used as a precursor to produce active androgens by 3βHSD, 5α-reductase and reductive 17βHSD activity (Nikolakis et al., 2016, Slominski et al., 2013).”

    From Intracrine androgen biosynthesis, metabolism and action revisited (2018) · cites this paper as Nikolakis et al., 2016

  • The resulting steroids from cutaneous steroidogenesis include glucocorticoids and androgens.

    “The resulting steroids include glucocorticoids and androgens and these pathways were reviewed in (Labrie et al., 2000, Nikolakis et al., 2016, Slominski et al., 2013).”

    From Intracrine androgen biosynthesis, metabolism and action revisited (2018) · cites this paper as Nikolakis et al., 2016

Citations

Cites

Flagged first, then by citations

Research works printed but not linked: 4

  1. Skobowiat C, Dowdy JC, Sayre RM, Tuckey RC, Slominski A. Cutaneous hypothalamic-pituitary-adrenal axis homolog: regulation by ultraviolet radiation. Am J Physiol Endocrinol Metab. 2011;301(3):E484–93. doi: 10.1152/ajpendo.00217.2011.10.1152/ajpendo.00217.2011 . · DOI · Paper page
  2. Billich A, Rot A, Lam C, Schmidt JB, Schuster I. Immunohistochemical localization of steroid sulfatase in acne lesions: implications for the contribution of dehydroepiandrosterone sulfate to the pathogenesis of acne. Hormone Metab Res = Hormon- und Stoffwechselforschung = Hormones et metabolisme. 2000;53:99.
  3. Bolognia JL, Schaffer JV, Duncan KO, Ko CJ. Dermatology Essentials E- Book. Elsevier Health Sciences; 2014.
  4. Skobowiat C, Sayre RM, Dowdy JC, Slominski AT. Ultraviolet radiation regulates cortisol activity in a waveband-dependent manner in human skin ex vivo. Br J Dermatol. 2013;168(3):595–601. doi: 10.1111/bjd.12096 . · DOI · Paper page

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Metadata

Authors
Nikolakis, G., Stratakis, C. A., Kanaki, T., Slominski, A., & Zouboulis, C. C.
Affiliations
  • Städtisches Klinikum Dessau (DE)
  • National Institutes of Health (US)
Corresponding author
Nikolakis, Georgios
ORCID
Venue
Reviews in Endocrine and Metabolic Disorders
Publisher
Springer Science and Business Media LLC
Published
2016-09
Volume
17
Issue
3
Pages
247-258
ISSN
  • 1389-9155 (ISSN-L)
  • 1573-2606
DOI
10.1007/s11154-016-9390-z
OpenAlex
W2538988300
Cited by
76
References
160
Citations by year
2026: 6 · 2025: 11 · 2024: 4 · 2023: 9 · 2022: 9 · 2021: 11 · 2020: 8 · 2019: 6 · 2018: 5 · 2017: 6 · 2016: 1
FWCI
0.86
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (unspecified)
Locations
  • Reviews in Endocrine and Metabolic Disorders (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
  • Physical Sciences › Chemistry › Organic Chemistry › Steroid Chemistry and Biochemistry
Keywords
sex steroids, glucocorticoids, cholesterol metabolism, acne, rosacea, atopic dermatitis, androgenetic alopecia
MeSH terms
Humans, Nutritional Physiological Phenomena, Skin Diseases, Skin Physiological Phenomena, Steroids

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