Effectiveness of Respiratory Hyperoxia, of Normobaric and of Hyperbaric Oxygen Atmospheres in Improving Tumor Oxygenation
Abstract
Tumor oxygenation during respiratory hyperoxia is dependent on the tumor growth site, on the growth stage, and hence on the vascular pattern. Diffusion of O2 from the surrounding atmosphere contributes considerably to the oxygenation of subcutaneous tumors during normobaric exposure to a pure O2 atmosphere. However, hypoxia is still present in the tumor core under these conditions, and pressurization up to 4 bar is required to completely eradicate these hypoxic areas, thus enhancing the radiosensitivity of the tumors.
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Atmospheric and hyperbaric hyperoxia can reduce the hypoxic area of tumors to varying degrees.
“Studies have shown that atmospheric and hyperbaric hyperoxia can reduce the hypoxic area of tumors to varying degrees.”
From Hypoxia signaling in cancer: Implications for therapeutic interventions (2023) · cites this paper as [301]
Cites
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Hypoxia signaling in cancer: Implications for therapeutic interventions
Zhuang, Y., Liu, K., He, Q., Gu, X., Jiang, C., & Wu, J. (2023) · MedComm · doi:10.1002/mco2.203 · Cited by 119 · see citing works
- Authors
- Mueller-Klieser, W., Vaupel, P., & Manz, R.
- Affiliations
- Johannes Gutenberg University Mainz (DE)
- University of Regensburg (DE)
- ORCID
- Vaupel, P.
- Venue
- Advances in Experimental Medicine and Biology
- Publisher
- Springer US
- Published
- 1984
- Volume
- 169
- Pages
- 613-619
- ISSN
- 0065-2598 (ISSN-L)
- OpenAlex
- W3188461
- Cited by
- 7
- References
- 13
- Citations by year
- 2023: 1
- FWCI
- 2.90
- Type
- book chapter
- Language
- en
- Open access
- closed
- Locations
- Advances in experimental medicine and biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Radiation Therapy and Dosimetry
- Physical Sciences › Engineering › Biomedical Engineering › Ultrasound and Hyperthermia Applications
- Keywords
- hyperbaric oxygen therapy, tumor oxygenation, radioresistance (biology), solid tumors, oxygen delivery, adjuvant radiotherapy
- MeSH terms
- Animals, Atmospheric Pressure, Diffusion, Hyperbaric Oxygenation, Neoplasms, Experimental, Oxygen, Oxygen Consumption, Regional Blood Flow
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