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Cited by 9Cardiovascular and exercise physiologyMitochondrial Function and PathologyPhysiological and biochemical adaptations

The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.

Skeletal Muscle Mitochondria: The Aerobic Gate?

Lindstedt, Stan L., Wells, Dominic J.·1988·Advances in experimental medicine and biology
DOI 10.1007/978-1-4684-5481-9_17
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Abstract

At an animal's maximum aerobic capacity (VO2max), the O2 flowing through the respiratory system is consumed by a functionally exclusive sink, skeletal muscle mitochondria. Thus, O2 consumption will never exceed the muscles O2 demand. If the system is ideally designed, structures upstream to the skeletal muscle O2 sink must be built to insure adequate O2 delivery to the working muscle. There are a number of structure-function solutions available to supply the demanded O2 to the muscle; these have been found to vary, often ontogenetically, with hypoxia, training, etc. But there is one relationship that is invariant: Total O2 uptake can be predicted by the total (active) skeletal muscle mitochondrial volume. In aerobic and sedentary animals, across a range of body sizes, maximum (in vivo) mitochondrial O2 consumption is constant among mammals (at approximately 2000 O2 molecules per square micron of inner mitochondrial membrane per second). Because the volume of mitochondria is one of the most plastic of all respiratory structures, we interpret this relationship as suggesting that skeletal muscle mitochondria alone sets the demand for O2 and, thus, the volume of skeletal muscle mitochondria dictates an animal's maximum aerobic capacity.

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Crossref · 10.1007/978-1-4684-5481-9_17

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Research works printed but not linked: 2

  1. Lindstedt, S.L., J.H. Jones, H. Hoppeler and H.A. Thronson, Jr. (1985b). Determinants of structure/function relations in the respiratory system: sufficiency vs. limitation. Physiologist 28:342 (abstract).
  2. Lindstedt, S.L. and J.H. Jones (1987). Syramorphosis: the concept of optimal designed. In, M. Feder, A.F. Bennett, W. Burrgren and R. Huey (eds.), New Directions in Physiological Ecology. Cambridge University Press. (In press).

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Metadata

Authors
Lindstedt, S. L., & Wells, D. J.
Affiliations
University of Wyoming (US)
ORCID
Venue
Advances in experimental medicine and biology
Publisher
Springer US
Published
1988
Volume
227
Pages
207-213
ISSN
0065-2598 (ISSN-L)
DOI
10.1007/978-1-4684-5481-9_17
OpenAlex
W2266878489
Cited by
9
References
36
Citations by year
2024: 1 · 2021: 1 · 2016: 1
FWCI
1.72
Type
book chapter
Language
en
Open access
closed
Locations
  • Advances in experimental medicine and biology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
  • Physical Sciences › Environmental Science › Ecology › Physiological and biochemical adaptations
Keywords
skeletal muscle mitochondria, maximal aerobic capacity, oxygen consumption, mitochondrial volume, oxygen delivery, hypoxia, exercise training, ontogeny, mammals, body size, respiratory physiology
MeSH terms
Animals, Humans, Mitochondria, Muscle, Oxygen Consumption

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