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Cited by 83Epilepsy research and treatmentMemory and Neural MechanismsNeuroscience and Neuropharmacology Research

Febrile seizures and mechanisms of epileptogenesis: insights from an animal model

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Bender, Roland A., Dubé, Celine, Baram, Tallie Z.·2004·Advances in Experimental Medicine and Biology
DOI 10.1007/978-1-4757-6376-8_15PMC PMC3086822
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Abstract

Temporal lobe epilepsy (TLE) is the most prevalent type of human epilepsy, yet the causes for its development, and the processes involved, are not known. Most individuals with TLE do not have a family history, suggesting that this limbic epilepsy is a consequence of acquired rather than genetic causes. Among suspected etiologies, febrile seizures have frequently been cited. This is due to the fact that retrospective analyses of adults with TLE have demonstrated a high prevalence (20-->60%) of a history of prolonged febrile seizures during early childhood, suggesting an etiological role for these seizures in the development of TLE. Specifically, neuronal damage induced by febrile seizures has been suggested as a mechanism for the development of mesial temporal sclerosis, the pathological hallmark of TLE. However, the statistical correlation between febrile seizures and TLE does not necessarily indicate a causal relationship. For example, preexisting (genetic or acquired) 'causes' that result independently in febrile seizures and in TLE would also result in tight statistical correlation. For obvious reasons, complex febrile seizures cannot be induced in the human, and studies of their mechanisms and of their consequences on brain molecules and circuits are severely limited. Therefore, an animal model was designed to study these seizures. The model reproduces the fundamental key elements of the human condition: the age specificity, the physiological temperatures seen in fevers of children, the length of the seizures and their lack of immediate morbidity. Neuroanatomical, molecular and functional methods have been used in this model to determine the consequences of prolonged febrile seizures on the survival and integrity of neurons, and on hyperexcitability in the hippocampal-limbic network. Experimental prolonged febrile seizures did not lead to death of any of the seizure-vulnerable populations in hippocampus, and the rate of neurogenesis was also unchanged. Neuronal function was altered sufficiently to promote synaptic reorganization of granule cells, and transient and long-term alterations in the expression of specific genes were observed. The contribution of these consequences of febrile seizures to the epileptogenic process is discussed.

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  • Local GABAergic networks that counteract excitation develop slowly between PND10-21, contributing to the susceptibility of the neonatal mammalian brain to seizure.

    “However, the local GABAergic networks that counteract excitation develop slowly between PND10-21 (Danglot et al., 2006), contributing to the susceptibility of the neonatal mammalian brain to seizure (Bender et al., 2004).”

    From Pathogenic SYNGAP1 Mutations Impair Cognitive Development by Disrupting Maturation of Dendritic Spine Synapses (2012) · cites this paper as Bender et al., 2004

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Research works printed but not linked: 6

  1. [27]Dubé C, Chen K, Eghbal-Ahmadi M, et al. Prolonged febrile seizures in the immature rat model enhance hippocampal excitability long term. Ann Neurol. 2000;47:336–344. [PMC free article] [PubMed] [Google Scholar]
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Authors
Bender, R. A., Dubé, C., & Baram, T. Z.
Affiliations
University of California, Irvine (US)
ORCID
Venue
Advances in Experimental Medicine and Biology
Publisher
Springer US
Published
2004
Volume
548
Pages
213-225
ISSN
0065-2598 (ISSN-L)
DOI
10.1007/978-1-4757-6376-8_15
PMC
PMC3086822
OpenAlex
W1598112592
Cited by
83
References
84
Citations by year
2025: 3 · 2024: 3 · 2023: 5 · 2022: 3 · 2021: 3 · 2020: 2 · 2019: 2 · 2018: 4 · 2017: 4 · 2016: 6 · 2015: 2 · 2014: 3 · 2013: 3 · 2012: 6
FWCI
23.11
Type
book chapter
Language
en
Open access
Locations
  • Advances in experimental medicine and biology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • eScholarship (California Digital Library) (submittedVersion, cc-by)
Funders
National Institute of Neurological Disorders and Stroke (NS-35439, R01NS035439)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Epilepsy research and treatment
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
febrile seizures, epileptogenesis, temporal lobe epilepsy, hippocampal sclerosis, neuronal survival, neurogenesis, gene expression changes, limbic epilepsy
MeSH terms
Animals, Seizures, Febrile, Disease Models, Animal, Epilepsy, Temporal Lobe, Humans, Infant, Rats

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