Changes in cerebral blood oxygenation induced by active standing test in children with pots and nms
Abstract
Orthostatic dysregulation (OD) has been classified into subtypes by heart rate and blood pressure; however, the hemodynamics of brains have not yet been revealed. Therefore, we investigated changes in cerebral blood flow and oxygenation during an active standing test to clarify the pathophysiology of two subtypes: postural tachycardia syndrome (POTS) and neurally mediated syncope (NMS). We studied 31 children (15 boys, 16 girls; mean age, 14.0 ± 1.7 years) who presented with OD at the Department of Pediatrics and Child Health, Nihon University School of Medicine between 2009 and 2011. OD was diagnosed using the Japanese clinical guidelines for juvenile orthostatic dysregulation. After a 10-min resting period in the supine position, patients were asked to quickly stand up and keep upright for 10 min. Cerebral blood flow and cerebral oxygenation were measured using transcranial Doppler sonography and near-infrared spectroscopy. POTS showed a significant decrease of oxy-Hb and resistance index (RI), suggesting transient ischemia with maintainable cerebral autoregulation. NMS showed a decrease of oxy-Hb and an increase of RI, suggesting ischemia and impairment of autoregulation.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Some studies found preserved dynamic cerebral perfusion and autoregulation in POTS patients during orthostatic stress.
“Some studies have shown that dynamic cerebral perfusion and autoregulation are preserved in POTS patients during orthostatic stress (Schondorf et al., 2005;Endo et al., 2014).”
From Postural tachycardia syndrome – Diagnosis, physiology, and prognosis (2018) · cites this paper as Endo et al., 2014
Cites
Noninvasive transcranial Doppler ultrasound recording of flow velocity in basal cerebral arteries
Aaslid, R., Markwalder, T.-M., & Nornes, H. (1982) · Journal of neurosurgery · doi:10.3171/jns.1982.57.6.0769 · Cited by 3,075 · see citing works
Estimation of optical pathlength through tissue from direct time of flight measurement
Delpy, D. T., Cope, M., van der Zee, P., Arridge, S., Wray, S., & Wyatt, J. S. (1988) · Physics in Medicine and Biology · doi:10.1088/0031-9155/33/12/008 · Cited by 2,251 · see citing works
Transcranial Doppler Sonography
Aaslid, R. (1986) · Springer eBooks · doi:10.1007/978-3-7091-8864-4 · Cited by 543 · see citing works
Syncope, cerebral perfusion, and oxygenation
LIESHOUT, J. J. V., Wieling, W., Karemaker, J. M., & Secher, N. H. (2003) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00260.2002 · Cited by 366 · see citing works
Autoregulation of Cerebral Blood Flow in Orthostatic Hypotension
Novak, V., Novák, P., Spies, J. M., & Low, P. A. (1998) · Stroke · doi:10.1161/01.str.29.1.104 · Cited by 242 · see citing works
Cerebral Oxygenation and Electrical Activity After Birth Asphyxia: Their Relation to Outcome
Toet, M. C., Lemmers, P. M. A., van Schelven, L. J., & van Bel, F. (2006) · PEDIATRICS · doi:10.1542/peds.2005-0987 · Cited by 238 · see citing works
Transcranial Doppler Examination Techniques
Aaslid, R. (1986) · Springer eBooks · doi:10.1007/978-3-7091-8864-4_4 · Cited by 229 · see citing works
Orthostatic Tolerance, Cerebral Oxygenation, and Blood Velocity in Humans With Sympathetic Failure
Harms, M. P. M., Colier, W. N. J. M., Wieling, W., et al. (2000) · Stroke · doi:10.1161/01.str.31.7.1608 · Cited by 125 · see citing works
Japanese clinical guidelines for juvenile orthostatic dysregulation version 1
Tanaka, H., Fujita, Y., 竹中, 義., Kajiwara, S., Masutani, S., Ishizaki, Y., Matsushima, R., 塩川宏郷, Shiota, M., Ishitani, N., et al. (2009) · Pediatrics International · doi:10.1111/j.1442-200x.2008.02783.x · Cited by 107 · see citing works
Self-citationTanaka, H., Matsushima, R., Tamai, H., & Kajimoto, Y. (2002) · The Journal of Pediatrics · doi:10.1067/mpd.2002.122725 · Cited by 78 · see citing works
Nagamitsu, S., Nagano, M., Yamashita, Y., et al. (2006) · Brain and Development · doi:10.1016/j.braindev.2005.11.008 · Cited by 72 · see citing works
The Doppler Principle Applied to Measurement of Blood Flow Velocity in Cerebral Arteries
Aaslid, R. (1986) · Springer eBooks · doi:10.1007/978-3-7091-8864-4_3 · Cited by 66 · see citing works
Mehagnoul‐Schipper, D. J., Colier, W. N. J. M., & Jansen, R. W. M. M. (2001) · Clinical Physiology · doi:10.1046/j.1365-2281.2001.00290.x · Cited by 45 · see citing works
Cerebral blood flow during vasovagal syncope induced by active standing or head up tilt
Sung, R. Y. T. (2000) · Archives of Disease in Childhood · doi:10.1136/adc.82.2.154 · Cited by 40 · see citing works
Elwell, C. E., Owen-Reece, H., Wyatt, J. S., et al. (1996) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-199603000-00022 · Cited by 40 · see citing works
Warkentin, S., Passant, U., Minthon, L., et al. (1992) · Clinical Autonomic Research · doi:10.1007/bf01819667 · Cited by 34 · see citing works
Syncope Resulting from Autonomic Insufficiency Syndromes Associated with Orthostatic Intolerance
Grubb, B. P., & KOSINSKI, D. J. (2001) · Medical Clinics of North America · doi:10.1016/s0025-7125(05)70322-9 · Cited by 25 · see citing works
OKUNI, M. (1963) · Japanese Circulation Journal-english Edition · doi:10.1253/jcj.27.200 · Cited by 21 · see citing works
Kim, Y. T., Tanaka, H., Takaya, R., Kajiura, M., Tamai, H., & Arita, M. (2009) · Acta Paediatrica · doi:10.1111/j.1651-2227.2008.01113.x · Cited by 17 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Postural tachycardia syndrome – Diagnosis, physiology, and prognosis
Arnold, A. C., Ng, J., & Raj, S. R. (2018) · Autonomic Neuroscience · doi:10.1016/j.autneu.2018.02.005 · Cited by 186 · see citing works
- Authors
- Endo, A., Fujita, Y., Fuchigami, T., Takahashi, S., Mugishima, H., & Skatani, K.
- Affiliations
- Nihon University (JP)
- Corresponding author
- Fujita, Yukihiko
- ORCID
- Takahashi, Shori
- Venue
- Advances in Experimental Medicine and Biology
- Publisher
- Springer New York
- Published
- 2014
- Volume
- 812
- Pages
- 253-261
- ISSN
- 0065-2598 (ISSN-L)
- 2214-8019
- OpenAlex
- W2289260701
- Cited by
- 15
- References
- 19
- Citations by year
- 2024: 1 · 2023: 3 · 2022: 2 · 2021: 1 · 2020: 2 · 2019: 3 · 2018: 2 · 2017: 1
- FWCI
- 2.95
- Type
- book chapter
- Language
- en
- Open access
- closed
- Locations
- Advances in experimental medicine and biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Cardiovascular Syncope and Autonomic Disorders
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Life Sciences › Neuroscience › Neurology › Vestibular and auditory disorders
- Keywords
- postural orthostatic tachycardia syndrome, neurally mediated syncope, orthostatic dysregulation, cerebral blood flow, cerebral oxygenation, active standing test, cerebral autoregulation, cerebral ischemia, children, oxyhemoglobin, resistance index
- MeSH terms
- Cerebrovascular Circulation, Child, Female, Humans, Male, Oxygen, Posture, Syncope, Postural Orthostatic Tachycardia Syndrome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
