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Assessment and Treatment of Neuropsychiatric Symptoms in Alzheimer’s Disease
Abstract
Neuropsychiatric symptoms are a common feature of Alzheimer’s disease (AD). The most common neuropsychiatric symptoms are apathy (72%), aggression/agitation (60%), anxiety (48%), and depression (48%) (1). Patients with psychosis experience a more rapid cognitive decline. The development of these symptoms is particularly problematic for patients and caregivers, and is frequently the factor that leads to nursing home placement. Hence, psychiatric symptoms may be thought of as having a particularly ominous prognostic significance if not detected and treated. Successful complete or partial treatment may reduce patient distress and extend independent living in AD patients (2). Neuropsychiatric symptoms are not always disclosed to physicians by patients or caregivers until they are intolerable, or precipitate a crisis. Routine clinical assessments may allow more proactive clinical management.
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Anxiety symptoms occur in 50-75% of AD patients.
“Anxiety symptoms occur in 50-75% of AD patients (Gustavson et al., 2004)”
From Apolipoprotein E–low density lipoprotein receptor interaction affects spatial memory retention and brain ApoE levels in an isoform-dependent manner (2014) · cites this paper as Gustavson et al., 2004
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Johnson, L. A., Olsen, R. H. J., Merkens, L. S., DeBarber, A., Steiner, R. D., Sullivan, P. M., Maeda, N., & Raber, J. (2014) · Neurobiology of Disease · doi:10.1016/j.nbd.2013.12.016 · Cited by 107
Metadata
- Authors
- Gustavson, A. R., & Cummings, J. L.
- Venue
- Alzheimer’s Disease
- Publisher
- Humana Press
- Published
- 2004
- Pages
- 371-385
- Cited by
- 1
- References
- 1
- Language
- en
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