Chemistry and Analysis of Phytocannabinoids and Other Cannabis Constituents
Abstract
The Cannabis plant and its products consist of an enormous variety of chemicals. Some of the 483 compounds identified are unique to Cannabis, for example, the more than 60 cannabinoids, whereas the terpenes, with about 140 members forming the most abundant class, are widespread in the plant kingdom. The term “cannabinoids” [note: “ ” represents a group of C21 terpenophenolic compounds found until now uniquely in Cannabis sativa L. (). As a consequence of the development of synthetic cannabinoids (e.g., nabilone [2], HU-211 [dexanabinol; ref. (3), or ajulemic acid [CT-3; ref. 4]) and the discovery of the chemically different endogenous cannabinoid receptor ligands (“endocannabinoids,” e.g., anandamide, 2-arachidonoylglycerol) (5,6), the term ’“phytocannabinoids’” was proposed for these particular Cannabis constituents (7).
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More than 90 different cannabinoids have been reported in the literature, although some of these are breakdown products, and they are generally classified into 10 subclasses.
“More than 90 different cannabinoids have been reported in the literature, although some of these are breakdown products (ElSohly and Slade, 2005; Brenneisen, 2007; Radwan et al., 2009; Fischedick et al., 2010) and they are generally classified into 10 subclasses (Brenneisen, 2007).”
From Cannabis sativa: The Plant of the Thousand and One Molecules (2016) · cites this paper as Brenneisen, 2007
Terpene yield and distribution in the plant vary according to numerous parameters, such as processes for obtaining essential oil, environmental conditions, or maturity of the plant.
“Terpene yield and distribution in the plant vary according to numerous parameters, such as processes for obtaining essential oil, environmental conditions, or maturity of the plant (Meier and Mediavilla, 1998; Brenneisen, 2007).”
From Cannabis sativa: The Plant of the Thousand and One Molecules (2016) · cites this paper as Brenneisen, 2007
Terpenes form the largest group of phytochemicals, with more than 100 molecules identified in Cannabis.
“Terpenes form the largest group of phytochemicals, with more than 100 molecules identified in Cannabis (Rothschild et al., 2005; Brenneisen, 2007).”
From Cannabis sativa: The Plant of the Thousand and One Molecules (2016) · cites this paper as Brenneisen, 2007
Cites
Cannabis and Cannabis Extracts: Greater Than the Sum of Their Parts?
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Cannabinoids in Clinical Practice
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CONSTITUENTS OF CANNABIS SATIVA L. XXVIII A REVIEW OF THE NATURAL CONSTITUENTS: 1980-1994
Ross, S., & EISohly, M. (1995) · Zagazig Journal of Pharmaceutical Sciences · doi:10.21608/zjps.1995.169714 · Cited by 59 · see citing works
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Cannabis sativa: The Plant of the Thousand and One Molecules
Andre, C. M., Hausman, J.-F., & Guerriero, G. (2016) · Frontiers in Plant Science · doi:10.3389/fpls.2016.00019 · Cited by 1,544 · see citing works
“Terpenes form the largest group of phytochemicals, with more than 100 molecules identified in Cannabis (Rothschild et al., 2005; Brenneisen, 2007).”
BackgroundCannabinoids, Phenolics, Terpenes and Alkaloids of Cannabis
Radwan, M. M., Chandra, S., Gul, S., & ElSohly, M. A. (2021) · Molecules · doi:10.3390/molecules26092774 · Cited by 397 · see citing works
Biologically Active Cannabinoids from High-Potency <i>Cannabis sativa</i>
Radwan, M. M., ElSohly, M. A., Slade, D., Ahmed, S. A., Khan, I. A., & Ross, S. A. (2009) · Journal of Natural Products · doi:10.1021/np900067k · Cited by 185 · see citing works
Biosynthesis of cannflavins A and B from Cannabis sativa L.
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“…yeast strain expressing the open-reading frames of CsPT1, 3, 4, 7, and 8 were recovered and tested for prenyltransferase activity with three flavone substrates that are present in C. sativa: apigenin, chrysoeriol, and luteolin (McPartland and Russo, 2001; Brenneisen, 2007; Radwan et al., 2008a,b).”
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Distinct functions of endogenous cannabinoid system in alcohol abuse disorders
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Chemistry and Biological Activities of Cannflavins of the Cannabis Plant
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Cannabis Extraction Technologies: Impact of Research and Value Addition in Latin America
Suárez-Jacobo, Á., Díaz Pacheco, A., Bonales-Alatorre, E., Castillo-Herrera, G. A., & García-Fajardo, J. A. (2023) · Molecules · doi:10.3390/molecules28072895 · Cited by 13 · see citing works
- Authors
- Brenneisen, R.
- Affiliations
- University of Bern (CH)
- Corresponding author
- Brenneisen, Rudolf
- Venue
- Forensic Science And Medicine
- Publisher
- Humana Press
- Published
- 2007-11-15
- Pages
- 17-49
- OpenAlex
- W1684343866
- Cited by
- 251
- References
- 3
- Citations by year
- 2026: 8 · 2025: 12 · 2024: 15 · 2023: 20 · 2022: 22 · 2021: 44 · 2020: 27 · 2019: 24 · 2018: 27 · 2017: 17 · 2016: 9 · 2015: 9 · 2014: 3 · 2013: 3
- FWCI
- 6.76
- Type
- book chapter
- Language
- en
- Open access
- closed
- Locations
- Humana Press eBooks (publishedVersion)
- BORIS (University Library Bern) (submittedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Forensic Toxicology and Drug Analysis
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Hops Chemistry and Applications
- Keywords
- phytocannabinoids, Cannabis sativa, cannabinoids, terpenes, synthetic cannabinoids, endocannabinoids, anandamide, 2-arachidonoylglycerol, nabilone, ajulemic acid
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