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Cited by 2Animal Genetics and ReproductionGenetic Mapping and Diversity in Plants and AnimalsGenetic and phenotypic traits in livestock

Rodent Genetics, Models, and Genotyping Methods

Wildt, Sheryl J., Brooks, Andrew I., Russell, Robert J.·2008·Sourcebook of Models for Biomedical Research
DOI 10.1007/978-1-59745-285-4_20
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Abstract

Laboratory mice (Mus musculus) and rats (Rattus norvegicus) are the most commonly used animals in biomedical and behavioral research. Today, there are many inbred, outbred, hybrid, congenic, and genetically modified mouse and rat models that have made essential contributions to advances in the diagnosis, prevention, and control of human disease. Routine genetic monitoring of these animals is essential to their successful use. Herein, we discuss the basic structure of the mouse and rat genome; common breeding protocols to preserve innate and exogenous genetic backgrounds; and the methods used for creating specific types of mutant model, research applications, and current genotyping methods.

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Crossref · 10.1007/978-1-59745-285-4_20

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1 of 1 references verified0 citation errors · 0 not checkable

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  • Rat strains are more commonly used as outbred stocks, so more genetic variability can be expected.

    “While the natural genetics of mice and rats follow the same principles, practically, it is important to note that rat stains are more commonly used as outbred stocks where more genetic variability can be expected (Brekke et al., 2018; Wildt et al., 2008).”

    From Rodent Genetic Models of Ah Receptor Signaling (2021) · cites this paper as Wildt et al., 2008

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Authors
Wildt, S. J., Brooks, A. I., & Russell, R. J.
Affiliations
Environmental and Occupational Health Sciences Institute (US)
Venue
Sourcebook of Models for Biomedical Research
Publisher
Humana Press
Published
2008-03-06
Pages
179-186
DOI
10.1007/978-1-59745-285-4_20
OpenAlex
W24771580
Cited by
2
References
1
Citations by year
2021: 1 · 2012: 1
FWCI
0.00
Type
book chapter
Language
en
Open access
closed
Locations
Humana Press eBooks (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Animal Genetics and Reproduction
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Mapping and Diversity in Plants and Animals
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and phenotypic traits in livestock
Keywords
rodent genetics, laboratory mice, laboratory rats, mouse genome, rat genome, inbred strains, hybrid strains, congenic strains, genetically modified mice, genetic background, genotyping methods, genetic monitoring

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