What's Wrong With My Mouse?: Behavioral Phenotyping of Transgenic and Knockout Mice
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Both rats and mice have a strong tendency to group together in laboratory conditions.
“This statement seems to reflect the observation that both of species have strong tendency to group together in laboratory conditions (ie, sleep in one corner of the cage).”
From Ecological validity of social interaction tests in rats and mice (2019) · cites this paper as [51]
Both rats and mice often display amicable behaviors such as crawling under each other, allogrooming, huddling, following, and sniffing.
“They often display behaviors described as”
From Ecological validity of social interaction tests in rats and mice (2019) · cites this paper as [51]
Laboratory mice have a tendency to group together and display all of the amicable behaviors mentioned previously for rats.
“They also have a tendency to group together and display all of the amicable behaviors mentioned previously.51,68”
From Ecological validity of social interaction tests in rats and mice (2019) · cites this paper as [51]
Mice are usually harder to habituate, but easier to house in big groups and complex environments.
“Mice are usually harder to habituate, but on the other hand easier to house in big groups and complex environments.1,51”
From Ecological validity of social interaction tests in rats and mice (2019) · cites this paper as [51]
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Behavioural phenotyping assays for mouse models of autism
Silverman, J. L., Yang, M., Lord, C., & Crawley, J. N. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2851 · Cited by 1,462 · see citing works
Self-citationAutism‐like behavioral phenotypes in BTBR T+tf/J mice
McFarlane, H. G., Kusek, G. K., Yang, M., Phoenix, J. L., Bolivar, V. J., & Crawley, J. N. (2008) · Genes, Brain and Behavior · doi:10.1111/j.1601-183x.2007.00330.x · Cited by 812 · see citing works
“Procedural abilities were examined to prevent overinterpretations of aberrant 152 doi: 10.1111/j.1601-183X.2007.00330.x social phenotypes (Crawley 2004, 2007).”
BackgroundInfluentialSelf-citationFemale mice liberated for inclusion in neuroscience and biomedical research
Prendergast, B. J., Onishi, K. G., & Zucker, I. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.01.001 · Cited by 788 · see citing works
Mouse behavioral tasks relevant to autism: Phenotypes of 10 inbred strains
MOY, S., NADLER, J., YOUNG, N., PEREZ, A., HOLLOWAY, L., BARBARO, R., BARBARO, J., WILSON, L., THREADGILL, D., & LAUDER, J. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.07.030 · Cited by 776 · see citing works
Optogenetic interrogation of neural circuits: technology for probing mammalian brain structures
Zhang, F., Gradinaru, V., Adamantidis, A. R., Durand, R., Airan, R. D., de Lecea, L., & Deisseroth, K. (2010) · Nature Protocols · doi:10.1038/nprot.2009.226 · Cited by 692 · see citing works
Automated Three‐Chambered Social Approach Task for Mice
Yang, M., Silverman, J. L., & Crawley, J. N. (2011) · Current Protocols in Neuroscience · doi:10.1002/0471142301.ns0826s56 · Cited by 598 · see citing works
“Number of transitions across chambers offers a built-in control measure of exploratory locomotion (Crawley, 2007b, 2008; McFarlane et al., 2008; Moy et al., 2008b, 2009; Yang et al., 2009, 2011a; Silverman et al., 2010 a,b).”
BackgroundSelf-citationMouse Behavioral Assays Relevant to the Symptoms of Autism*
Crawley, J. N. (2007) · Brain Pathology · doi:10.1111/j.1750-3639.2007.00096.x · Cited by 541 · see citing works
Self-citationNakatani, J., Tamada, K., Hatanaka, F., Ise, S., Ohta, H., Inoue, K., Tomonaga, S., Watanabe, Y., Chung, Y. J., Banerjee, R., et al. (2009) · Cell · doi:10.1016/j.cell.2009.04.024 · Cited by 482 · see citing works
The age of anxiety: role of animal models of anxiolytic action in drug discovery
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“…Rodgers, 1997; Holmes, 2001; Crawley, 2007), elevated zero maze (Lee and Rodgers, 1990; Shepherd et al., 1994), open-field test, light–dark box test (Crawley, 2007), staircase test (Simiand et al., 1984) and mirrored arena (Rodgers, 1997; Rodgers et al., 1997; Belzung and Griebel, 2001; Crawley,…”
BackgroundInfluentialαβγ-Synuclein triple knockout mice reveal age-dependent neuronal dysfunction
Greten-Harrison, B., Polydoro, M., Morimoto‐Tomita, M., Diao, L., Williams, A. M., Nie, E. H., Makani, S., Tian, N., Castillo, P. E., Buchman, V. L., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1005005107 · Cited by 305 · see citing works
Minimal aberrant behavioral phenotypes of neuroligin‐3 R451C knockin mice
Chadman, K. K., Gong, S., Scattoni, M. L., Boltuck, S. E., Gandhy, S. U., Heintz, N., & Crawley, J. N. (2008) · Autism Research · doi:10.1002/aur.22 · Cited by 292 · see citing works
“…and memory, and Morris water maze spatial learning and memory acquisition and reversal, as previously described [Bailey, Pavlova, Rohde, Hohmann, & Crawley, 2007; Crawley, 2007; Crawley & Goodwin, 1980; Crawley et al., 2007; McFarlane et al., 2008; Moy et al., 2007; Scattoni et al., 2008; Yang,…”
MethodSelf-citationPapaleo, F., Crawley, J. N., Song, J., Lipska, B. K., Pickel, J., Weinberger, D. R., & Chen, J. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.2077-08.2008 · Cited by 288 · see citing works
Self-citationKuo, Y., Li, Z., Jiao, Y., Gaborit, N., Pani, A. K., Orrison, B. M., Bruneau, B. G., Giasson, B. I., Smeyne, R. J., Gershon, M. D., et al. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq038 · Cited by 288 · see citing works
“The time each mouse spent sniffing was recorded (74).”
BackgroundClassics in Chemical Neuroscience: Diazepam (Valium)
Calcaterra, N. E., & Barrow, J. C. (2014) · ACS Chemical Neuroscience · doi:10.1021/cn5000056 · Cited by 284 · see citing works
Assessing autism-like behavior in mice: Variations in social interactions among inbred strains
BOLIVAR, V, WALTERS, S., & PHOENIX, J. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.09.007 · Cited by 264 · see citing works
“These behaviors have been routinely used to evaluate social behavior in rodents [5, 9,45,47] and were coded according to established definitions [19].”
BackgroundMethodEmotional endophenotypes in evolutionary psychiatry
Panksepp, J. (2006) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2006.01.004 · Cited by 246 · see citing works
“For instance, we already know that allelic variants that lead to anxiety, aggression, and social insecurities seem to be similar in mice, monkeys and men (Crawley, 2000).”
BackgroundTranslational animal models of autism and neurodevelopmental disorders
Crawley, J. N. (2012) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2012.14.3/jcrawley · Cited by 227 · see citing works
Self-citationPolycomb repressive complex 2 (PRC2) silences genes responsible for neurodegeneration
von Schimmelmann, M., Feinberg, P. A., Sullivan, J. M., Ku, S. M., Badimon, A., Duff, M. K., Wang, Z., Lachmann, A., Dewell, S., Ma'ayan, A., et al. (2016) · Nature Neuroscience · doi:10.1038/nn.4360 · Cited by 225 · see citing works
Halloran, J. J., Hussong, S. A., Burbank, R. R., Podlutskaya, N., Fischer, K. E., Sloane, L. B., Austad, S. N., Strong, R., Richardson, A. G., Hart, M. J., et al. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.06.054 · Cited by 221 · see citing works
“To determine whether anxiety was affected by rapamycin treatment in older mice we used a behavioral paradigm that is not associated with learning, the elevated plus maze, which assesses rodent’s reactivity using their innate aversion of open spaces and provides a direct measure of anxiety (Crawley, 2000).”
Assessing Spatial Working Memory Using the Spontaneous Alternation Y-maze Test in Aged Male Mice
Prieur, E. A. K., & Jadavji, N. M. (2019) · BIO-PROTOCOL · doi:10.21769/bioprotoc.3162 · Cited by 224 · see citing works
Normal cognitive and social development require posterior cerebellar activity
Badura, A., Verpeut, J. L., Metzger, J. W., Pereira, T. D., Pisano, T. J., Deverett, B., Bakshinskaya, D. E., & Wang, S. S.-H. (2018) · eLife · doi:10.7554/elife.36401 · Cited by 205 · see citing works
“Such experiments require detailed quantitative analysis because individual tasks combine motor and nonmotor capacities (Crawley, 2007).”
BackgroundA Mouse Model Characterizing Features of Vascular Dementia With Hippocampal Atrophy
Nishio, K., Ihara, M., Yamasaki, N., Kalaria, R. N., Maki, T., Fujita, Y., Ito, H., Oishi, N., Fukuyama, H., Miyakawa, T., et al. (2010) · Stroke · doi:10.1161/strokeaha.110.581686 · Cited by 202 · see citing works
Kondo, M., Gray, L. J., Pelka, G. J., Christodoulou, J., Tam, P. P. L., & Hannan, A. J. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06305.x · Cited by 190 · see citing works
“Motor learning was assessed by conducting one session per day for five consecutive days (Crawley, 2007), then comparing the performance on the fifth day to that on the first.”
MethodMulkey, D. K., Talley, E. M., Stornetta, R. L., Siegel, A. R., West, G. H., Chen, X., Sen, N., Mistry, A. M., Guyenet, P. G., & Bayliss, D. A. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.4254-07.2007 · Cited by 183 · see citing works
“To assay coordination and gross motor function of the mice, we used the rotarod and wire hang test, essentially as described (Crawley, 2000).”
MethodInfluentialMouse behavioral endophenotypes for schizophrenia
Amann, L. C., Gandal, M. J., Halene, T. B., Ehrlichman, R. S., White, S., McCarren, H. S., & Siegel, S. J. (2010) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2010.04.008 · Cited by 180 · see citing works
Olsson, I. A. S., & Westlund, K. (2006) · Applied Animal Behaviour Science · doi:10.1016/j.applanim.2006.05.022 · Cited by 180 · see citing works
“After isolation housing, male rodents react more aggressively when confronted 357 with a stranger; in fact, isolation-induced aggression is used as an experimental 358 paradigm in mice (e g Crawley, 2000).”
MethodBehavioral phenotypes of genetic mouse models of autism
Kazdoba, T. M., Leach, P. T., & Crawley, J. N. (2015) · Genes Brain & Behavior · doi:10.1111/gbb.12256 · Cited by 179 · see citing works
“Large numbers of mouse behavioral assays relevant to the diagnostic and associated symptoms of ASD are available to choose from (Crawley 2012; Silverman et al. 2010a), along with a wealth of relevant control tests (Crawley 2007).”
BackgroundSelf-citationShaltiel, G., Maeng, S., Malkesman, O., Pearson, B., Schloesser, R. J., Tragon, T., Rogawski, M., Gasior, M., Luckenbaugh, D., Chen, G., et al. (2008) · Molecular Psychiatry · doi:10.1038/mp.2008.20 · Cited by 173 · see citing works
Galton, V. A., Wood, E. T., Germain, E. A. S., Withrow, C.-A., Aldrich, G., Germain, G. M. S., Clark, A. S., & Germain, D. L. S. (2007) · Endocrinology · doi:10.1210/en.2006-1727 · Cited by 174 · see citing works
“Posturing, righting, eye blink, ear twitch, whiskerorienting reflex, and constriction and dilation of pupil were determined by standard methods (21).”
How should the psychological well‐being of zoo elephants be objectively investigated?
Mason, G. J., & Veasey, J. S. (2009) · Zoo Biology · doi:10.1002/zoo.20256 · Cited by 159 · see citing works
Validating GSK3 as an in vivo target of lithium action
O'Brien, W. T., & Klein, P. S. (2009) · Biochemical Society Transactions · doi:10.1042/bst0371133 · Cited by 157 · see citing works
Trainor, B. C., Pride, M. C., Villalon Landeros, R., Knoblauch, N. W., Takahashi, E. Y., Silva, A. L., & Crean, K. K. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017405 · Cited by 157 · see citing works
“for timeline), males and females were randomly assigned to defeat (n = 9 males, n = 9 females) or control conditions (n = 10 males, n = 10 females) as described for experiment 1. The number of offensive attacks was quantified during each episode of defeat. Starting 4 weeks after the last social defeat test, mice were…”
MethodNeurological sequelae resulting from encephalitic alphavirus infection
Ronca, S. E., Dineley, K. T., & Paessler, S. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.00959 · Cited by 157 · see citing works
“When testing hearing, a single click should result in an ear flick, jump, Frontiers in Microbiology | www.frontiersin.org 6 June 2016 | Volume 7 | Article 959 or brief head motionlessness (Crawley, 2007).”
BackgroundAnimal Models of Serotonergic Psychedelics
Hanks, J. B., & González-Maeso, J. (2013) · ACS Chemical Neuroscience · doi:10.1021/cn300138m · Cited by 156 · see citing works
Antidepressant-Like Effects of Ceftriaxone in Male C57BL/6J Mice
Mineur, Y. S., Picciotto, M. R., & Sanacora, G. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.04.037 · Cited by 150 · see citing works
Treatment of anxiety and depression: medicinal plants in retrospect
Fajemiroye, J. O., da Silva, D. M., de Oliveira, D. R., & Costa, É. A. (2016) · Fundamental and Clinical Pharmacology · doi:10.1111/fcp.12186 · Cited by 151 · see citing works
Pcdhαc2 is required for axonal tiling and assembly of serotonergic circuitries in mice
Chen, W. V., Nwakeze, C. L., Denny, C. A., O’Keeffe, S., Rieger, M. A., Mountoufaris, G., Kirner, A., Dougherty, J. D., Hen, R., Wu, Q., et al. (2017) · Science · doi:10.1126/science.aal3231 · Cited by 143 · see citing works
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Vasopressin 1a receptor knockout mice have a subtle olfactory deficit but normal aggression
Wersinger, S. R., Caldwell, H. K., Martinez, L. A., Gold, P. W., Hu, S.-B., & Young, W. S. (2006) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2006.00281.x · Cited by 139 · see citing works
“Basic sensorimotor exams are generally considered to be less affected by the phase of the light/ dark cycle (Crawley 2000).”
BackgroundMethodMalinowska, M., Wilkinson, F. L., Langford‐Smith, K., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0014192 · Cited by 139 · see citing works
“, although the small size of our arenas could have reduced these responses”
BackgroundEcological validity of social interaction tests in rats and mice
Kondrakiewicz, K., Kostecki, M., Szadzińska, W., & Knapska, E. (2019) · Genes, Brain and Behavior · doi:10.1111/gbb.12525 · Cited by 136 · see citing works
Early autophagic response in a novel knock-in model of Huntington disease
Heng, M. Y., Duong, D. K., Albin, R. L., Tallaksen‐Greene, S. J., Hunter, J. M., Lesort, M. J., Osmand, A., Paulson, H. L., & Detloff, P. J. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq285 · Cited by 126 · see citing works
“A recent systematic analysis of several models provides useful information for comparing the HhdQ200 line with other models, though this analysis did not use the balance beam task, which we found particularly useful (54,55).”
ResultDavis, D. A., Bortolato, M., Godar, S. C., Sander, T. K., Iwata, N., Pakbin, P., Shih, J. C., Berhane, K., McConnell, R., Sioutas, C., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0064128 · Cited by 123 · see citing works
Application of Mouse Models to Research in Hearing and Balance
Ohlemiller, K. K., Jones, S. M., & Johnson, K. R. (2016) · Journal of the Association for Research in Otolaryngology · doi:10.1007/s10162-016-0589-1 · Cited by 122 · see citing works
Reversal learning and attentional set-shifting in mice
Bissonette, G. B., & Powell, E. M. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.03.011 · Cited by 121 · see citing works
Criteria for validating mouse models of psychiatric diseases
Chadman, K. K., Yang, M., & Crawley, J. N. (2008) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30777 · Cited by 123 · see citing works
“Behavioral Phenotyping of Transgenic and Knockout Mice’’ [Crawley, 2007b], Current Protocols in Neuroscience, and in the many excellent review articles cited above.”
BackgroundSelf-citationGenetic Models of Sensorimotor Gating: Relevance to Neuropsychiatric Disorders
Powell, S. B., Weber, M., & Geyer, M. A. (2011) · Current topics in behavioral neurosciences · doi:10.1007/7854_2011_195 · Cited by 120 · see citing works
“For a discussion of the issue surrounding background strain the reader is referred to Crawley (2007) and Geyer et al. (2002).”
BackgroundMethodYi, F., Ball, J., Stoll, K., Satpute, V. C., Mitchell, S., Pauli, J. L., Holloway, B. B., Johnston, A. D., Nathanson, N. M., Deisseroth, K. A., et al. (2014) · The Journal of Physiology · doi:10.1113/jphysiol.2014.275453 · Cited by 118 · see citing works
Dhabhar, F. S., Saul, A. N., Holmes, T. H., Daugherty, C., Neri, E., Tillie, J. M., Kusewitt, D. F., & Oberyszyn, T. M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0033069 · Cited by 120 · see citing works
Engel, S. R., Creson, T. K., Hao, Y., Shen, Y., Maeng, S., Nekrasova, T., Landreth, G. E., Manji, H. K., & Chen, G. (2008) · Molecular Psychiatry · doi:10.1038/sj.mp.4002135 · Cited by 118 · see citing works
Papaleo, F., Silverman, J. L., Aney, J., Tian, Q., Barkan, C. L., Chadman, K. K., & Crawley, J. N. (2011) · Learning & Memory · doi:10.1101/lm.2213711 · Cited by 117 · see citing works
Self-citationGlycosyltransferase Function in Core 2-Type Protein O Glycosylation
Stone, E. L., Ismail, M. N., Lee, S. H., Luu, Y., Ramirez, K., Haslam, S. M., Ho, S. B., Dell, A., Fukuda, M., & Marth, J. D. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.00204-09 · Cited by 118 · see citing works
Gait Analysis Methods for Rodent Models of Osteoarthritis
Jacobs, B. Y., Kloefkorn, H. E., & Allen, K. D. (2014) · Current Pain and Headache Reports · doi:10.1007/s11916-014-0456-x · Cited by 113 · see citing works
Activation of astrocytes in hippocampus decreases fear memory through adenosine A1 receptors
Li, Y., Li, L., Wu, J., Zhu, Z., Feng, X., Qin, L., Zhu, Y., Sun, L., Liu, Y., Qiu, Z., et al. (2020) · eLife · doi:10.7554/elife.57155 · Cited by 117 · see citing works
“Rats are well-adapted to the natural environment and are generally considered to perform well in learning and memory tasks (Crawley, 2007).”
BackgroundLow sociability in BTBR T+tf/J mice is independent of partner strain
Yang, M., Abrams, D. N., Zhang, J. Y., Weber, M. D., Katz, A. M., Clarke, A. M., Silverman, J. L., & Crawley, J. N. (2012) · Physiology & Behavior · doi:10.1016/j.physbeh.2011.12.025 · Cited by 112 · see citing works
Self-citationDepression‐Related Behavioral Tests
Powell, T. R., Fernandes, C., & Schalkwyk, L. C. (2012) · Current Protocols in Mouse Biology · doi:10.1002/9780470942390.mo110176 · Cited by 114 · see citing works
“If the mouse is anxious, it will avoid the food and display limited exploration of the test environment, whereas less anxious mice will approach the food quickly and begin eating (Crawley, 2007).”
BackgroundQuantitative cellular-resolution map of the oxytocin receptor in postnatally developing mouse brains
Newmaster, K. T., Nolan, Z. T., Chon, U., Vanselow, D. J., Weit, A. R., Tabbaa, M., Hidema, S., Nishimori, K., Hammock, E. A. D., & Kim, Y. (2020) · Nature Communications · doi:10.1038/s41467-020-15659-1 · Cited by 109 · see citing works
Bains, R., Cater, H. L., Sillito, R., Chartsias, A., Sneddon, D., Concas, D., Keskivali-Bond, P., Lukins, T., Wells, S., Acevedo-Arozena, A., et al. (2016) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2016.00106 · Cited by 110 · see citing works
Hattori, S., Murotani, T., Matsuzaki, S., Ishizuka, T., Kumamoto, N., Takeda, M., Tohyama, M., Yamatodani, A., Kunugi, H., & Hashimoto, R. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.06.016 · Cited by 107 · see citing works
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Endothelial cell-derived GABA signaling modulates neuronal migration and postnatal behavior
Li, S., Pandit, P. K. T., Joshee, S., Kirschstein, T., Subburaju, S., Khalili, J. S., Kloepper, J., Du, C., Elkhal, A., Szabó, G., et al. (2017) · Cell Research · doi:10.1038/cr.2017.135 · Cited by 102 · see citing works
Karlsson, R., Choe, J. S., Cameron, H. A., Thorsell, A., Crawley, J. N., Holmes, A., & Heilig, M. A. (2007) · Psychopharmacology · doi:10.1007/s00213-007-0945-2 · Cited by 105 · see citing works
“To exclude possible gross behavioral confounds affecting fear-, anxiety-, and depression-related behaviors, Y1R −/− mice were first evaluated for empty cage behaviors, physical health, sensory, and neurological functions as previously described (Boyce-Rustay and Holmes 2006; Crawley 2007).”
MethodSelf-citationIntracellular signaling pathways that regulate behavioral responses to ethanol
Newton, P. M., & Messing, R. O. (2005) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2005.07.004 · Cited by 103 · see citing works
Pañeda, C., Huitrón‐Reséndiz, S., Frago, L. M., Chowen, J. A., Picetti, R., de Lecea, L., & Roberts, A. J. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.5256-08.2009 · Cited by 104 · see citing works
Behavioral phenotyping of Neuropeptide S receptor knockout mice
Duangdao, D. M., Clark, S. D., Okamura, N., & Reinscheid, R. K. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.07.024 · Cited by 103 · see citing works
Mercer, R. E., Kwolek, E., Bischof, J. M., van Eede, M., Henkelman, R. M., & Wevrick, R. (2009) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30934 · Cited by 103 · see citing works
“…the acquisition of developmental milestones (e.g., physical development, rooting reflex, righting reflex, forelimb/hind limb grasping, or locomotor behavior [Crawley, 2007]) were noted in Magel2-null mice compared to control littermates from birth to 3 weeks of age, suggesting adequate muscle tone.”
BackgroundCritical period for acoustic preference in mice
Yang, E.-J., Lin, E. W., & Hensch, T. K. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1200705109 · Cited by 102 · see citing works
Freedom of movement and the stability of its unfolding in free exploration of mice
Fonio, E., Benjamini, Y., & Golani, I. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0812513106 · Cited by 98 · see citing works
Ying, M., Xu, R., Wu, X., Zhu, H., Zhuang, Y., Han, M., & Xu, T. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m511677200 · Cited by 103 · see citing works
“In the hanging wire test, Atro-118Q mice showed tremor and myoclonus, indicating a neuromuscular abnormality ( 35 , 38).”
BackgroundMethodInfluentialCheng, J. S., Craft, R., Yu, G.-Q., Ho, K., Wang, X., Mohan, G., Mangnitsky, S., Ponnusamy, R., & Mucke, L. (2014) · PLoS ONE · doi:10.1371/journal.pone.0115765 · Cited by 100 · see citing works
Garcia‐Cairasco, N., Umeoka, E. H. D. L., & de Oliveira, J. A. C. (2017) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2017.04.001 · Cited by 99 · see citing works
The neurobiology of autism spectrum disorders
Parellada, M., Penzol, M. J., Pina‐Camacho, L., Moreno, C., González‐Vioque, E., Zalsman, G., & Arango, C. (2013) · European Psychiatry · doi:10.1016/j.eurpsy.2013.02.005 · Cited by 101 · see citing works
Loss of hypothalamic corticotropin-releasing hormone markedly reduces anxiety behaviors in mice
Zhang, R., Asai, M., Mahoney, C. E., Joachim, M., Shen, Y., Gunner, G., & Majzoub, J. A. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.136 · Cited by 97 · see citing works
Persistent post-stroke depression in mice following unilateral medial prefrontal cortical stroke
Vahid-Ansari, F., Lagace, D. C., & Albert, P. R. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.124 · Cited by 96 · see citing works
Hyperactivity and male‐specific sleep deficits in the 16p11.2 deletion mouse model of autism
Angelakos, C. C., Watson, A. J., O'Brien, W. T., Krainock, K. S., Nickl‐Jockschat, T., & Abel, T. (2017) · Autism Research · doi:10.1002/aur.1707 · Cited by 83 · see citing works
“2 del/1 and WT littermate offspring were used for all experiments in accordance with age ranges utilized in previous mouse sleep experiments [Mang et al., 2016; Vassalli et al., 2013; Wimmer et al., 2013] and guidelines for assessment of behavior in adult mice [Crawley, 2007].”
MethodInducible and reversible phenotypes in a novel mouse model of Friedreich’s Ataxia
Chandran, V., Gao, K., Swarup, V., Versano, R., Dong, H., Jordan, M. C., & Geschwind, D. H. (2017) · eLife · doi:10.7554/elife.30054 · Cited by 96 · see citing works
“The value of hind-paw grip strength normalized by the mouse body weight in the test week was used for data analysis ( Crawley, 2007 ).”
BackgroundMethodHattori, S., Hashimoto, R., Miyakawa, T., Yamanaka, H., Maeno, H., Wada, K., & Kunugi, H. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2007.02.036 · Cited by 94 · see citing works
Aβ alters the connectivity of olfactory neurons in the absence of amyloid plaques in vivo
Cao, L., Schrank, B. R., Rodriguez, S., Benz, E. G., Moulia, T. W., Rickenbacher, G. T., Gomez, A. C., Levites, Y., Edwards, S. R., Golde, T. E., et al. (2012) · Nature Communications · doi:10.1038/ncomms2013 · Cited by 93 · see citing works
Ben‐Shaul, Y. (2017) · BMC Biology · doi:10.1186/s12915-017-0377-3 · Cited by 93 · see citing works
Social Deficits and Perseverative Behaviors, but not Overt Aggression, in MAO-A Hypomorphic Mice
Bortolato, M., Chen, K., Godar, S. C., Chen, G., Wu, W., Rebrin, I., Farrell, M. R., Scott, A. L., Wellman, C. L., & Shih, J. C. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.157 · Cited by 90 · see citing works
“Prior to characterization of emotional behaviors, MAO-A mice were tested for physical features (general appearance, body weight, body temperature, posture and gait, heart rate, breathing frequency) and neurological reflexes (righting reflex, postural reflex, eye-blink reflex, and whiskerorienting reflex) as indicated…”
MethodLotan, A., Fencková, M., Bralten, J., O’Leary, A., Dixson, L., Williams, R. W., & van der Voet, M. (2014) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00331 · Cited by 87 · see citing works
Monteiro, C., Miarka, L., Perea-García, M., Priego, N., García‐Gómez, P., Álvaro‐Espinosa, L., de Pablos-Aragoneses, A., Yebra, N., Retana, D., Baena, P., et al. (2022) · Nature Medicine · doi:10.1038/s41591-022-01749-8 · Cited by 85 · see citing works
Ryu, J., Futai, K., Feliú-Mójer, M. I., Weinberg, R. J., & Sheng, M. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.1944-08.2008 · Cited by 85 · see citing works
Miller, B. H., Schultz, L. E., Gulati, A. D., Su, A. I., & Pletcher, M. T. (2010) · PLoS ONE · doi:10.1371/journal.pone.0014458 · Cited by 83 · see citing works
“In order to determine the role that the stress response and general activity levels might play in the expression of TST behavior, we phenotyped all 33 strains in the Open Field test. In the OF, overall distance traveled during the test is used as a measure of general activity, and thigmotaxis (preference for the wall…”
MethodStagni, F., Giacomini, A., Emili, M., Trazzi, S., Guidi, S., Sassi, M., Ciani, E., Rimondini, R., & Bartesaghi, R. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.07.031 · Cited by 76 · see citing works
Zhao, L., Kim, K. W., Ikeda, Y., Anderson, K. K., Beck, L., Chase, S., Tobet, S. A., & Parker, K. L. (2008) · Molecular Endocrinology · doi:10.1210/me.2008-0034 · Cited by 80 · see citing works
Two different putative genetic animal models of childhood depression—A review
Malkesman, O., & Weller, A. (2009) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2009.03.003 · Cited by 79 · see citing works
“Alternatively, this may simply reflect strain-differences or inbred vs. outbred strain-differences (Crawley, 2007; pp. 21–23).”
Maturation of auditory neural processes in autism spectrum disorder — A longitudinal MEG study
Port, R. G., Edgar, J. C., Ku, M., Bloy, L., Murray, R., Blaskey, L., Levy, S. E., & Roberts, T. P. L. (2016) · NeuroImage: Clinical · doi:10.1016/j.nicl.2016.03.021 · Cited by 79 · see citing works
Pratt, L., Ni, L., Ponzio, N. M., & Jonakait, G. M. (2013) · Pediatric Research · doi:10.1038/pr.2013.126 · Cited by 77 · see citing works
Coronin 1 Regulates Cognition and Behavior through Modulation of cAMP/Protein Kinase A Signaling
Jayachandran, R., Liu, X., Dasgupta, S. B., Müller, P., Zhang, C.-L., Moshous, D., Studer, V., Schneider, J., Genoud, C., Fossoud, C., et al. (2014) · PLoS Biology · doi:10.1371/journal.pbio.1001820 · Cited by 78 · see citing works
“’’ Regarding the elevated plus maze test, this is a conflict test based on a natural tendency of mice to actively explore a new environment, versus the aversive properties of an elevated open runway [27,79] (see Text S1 ‘‘Materials and Methods’’).”
BackgroundMethodInfluentialMedendorp, W. E., Petersen, E. D., Pal, A., Wagner, L., Myers, A. R., Hochgeschwender, U., & Jenrow, K. A. (2018) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2018.00087 · Cited by 75 · see citing works
“Social behavior was tested using the 3-chamber test (Crawley, 2007; Yang et al., 2011).”
MethodOf mice and men: modelling post‐stroke depression experimentally
Kronenberg, G., Gertz, K. R., Heinz, A., & Endres, M. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12775 · Cited by 75 · see citing works
“Since a single behavioural measure is easily liable to misinterpretation, it is generally desirable that a comprehensive multi-tiered battery of tests be conducted (Crawley, 2007).”
BackgroundMontgomery, K. S., Mackey, J., Thuett, K. A., Ginestra, S., Bizon, J. L., & Abbott, L. C. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.03.008 · Cited by 75 · see citing works
Measuring Anxiety-Like Behaviors in Rodent Models of Traumatic Brain Injury
Tucker, L. B., & McCabe, J. T. (2021) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2021.682935 · Cited by 78 · see citing works
“The most common measures analyzed include total horizontal distance traveled, number of rearing episodes [see (Sturman et al., 2018) for discussion], freezing, number of fecal boli, and proportion of time spent in a software-defined center zone of the apparatus (Crawley, 2007).”
BackgroundMethodInfluentialKahnau, P., Mieske, P., Wilzopolski, J., Kalliokoski, O., Mandillo, S., Hölter, S. M., Võikar, V., Amfim, A., Badurek, S., Bartelik, A., et al. (2023) · BMC Biology · doi:10.1186/s12915-023-01751-7 · Cited by 72 · see citing works
Loss of junctophilin‐3 contributes to huntington disease‐like 2 pathogenesis
Seixas, A. I., Holmes, S. E., Takeshima, H., Pavlovich, A. L., Sachs, N. A., Pruitt, J. L., Silveira, I., Ross, C. A., Margolis, R. L., & Rudnicki, D. D. (2011) · Annals of Neurology · doi:10.1002/ana.22598 · Cited by 73 · see citing works
Oberlin, B. G., Best, C., Matson, L. M., Henderson, A. N., & Grahame, N. J. (2010) · Behavior Genetics · doi:10.1007/s10519-010-9394-5 · Cited by 72 · see citing works
“In addition, inbreeding results in a unique and rather unusual genotype that may have numerous behavioral and physiological abnormalities (Crawley 2007), so results obtained with one inbred strain cannot necessarily be generalized to a population as a whole (Crabbe et al. 1990; Falconer and Mackay…”
Labrie, V., Clapcote, S., & Roder, J. (2009) · Pharmacology, Biochemistry and Behavior · doi:10.1016/j.pbb.2008.09.016 · Cited by 72 · see citing works
- Authors
- Crawley, J. N.
- Corresponding author
- Crawley, Jacqueline N.
- Venue
- Wiley eBooks
- Publisher
- Wiley
- Published
- 2006-08-24
- OpenAlex
- W46255818
- Cited by
- 474
- References
- 0
- Citations by year
- 2026: 15 · 2025: 12 · 2024: 33 · 2023: 15 · 2022: 19 · 2021: 23 · 2020: 19 · 2019: 18 · 2018: 18 · 2017: 20 · 2016: 30 · 2015: 27 · 2014: 31 · 2013: 31 · 2012: 34
- FWCI
- 10.25
- Type
- book
- Language
- en
- Open access
- closed
- Locations
- Wiley eBooks (publishedVersion)
- Topics
- Health Sciences › Veterinary › Small Animals › Veterinary Medicine and Surgery
- Health Sciences › Veterinary › Small Animals › Animal Behavior and Welfare Studies
- Health Sciences › Medicine › Psychiatry and Mental health › Medicine, History, and Philosophy
- Keywords
- troubleshooting, computer hardware
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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