In Vitro Antibody Affinity Maturation Targeting Germline Hotspots

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Improved cytotoxic activity toward cell lines and fresh leukemia cells of a mutant anti-CD22 immunotoxin obtained by antibody phage display.

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Monitoring and interpreting the intrinsic features of somatic hypermutation

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In Vitro Antibody Evolution Targeting Germline Hot Spots to Increase Activity of an Anti-CD22 Immunotoxin

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Genome-wide somatic hypermutation

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The targeting of somatic hypermutation

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Immunotoxins with increased activity against epidermal growth factor receptor vIII-expressing cells produced by antibody phage display.

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Ligand-assisted Aggregation of Proteins

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Deep learning guided optimization of human antibody against SARS-CoV-2 variants with broad neutralization

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Therapeutically targeting glypican-2 via single-domain antibody-based chimeric antigen receptors and immunotoxins in neuroblastoma

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The role of phage display in therapeutic antibody discovery

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Construction and next-generation sequencing analysis of a large phage-displayed VNAR single-domain antibody library from six naïve nurse sharks

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A novel high‐affinity human monoclonal antibody to mesothelin

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A Human Single-Domain Antibody Elicits Potent Antitumor Activity by Targeting an Epitope in Mesothelin Close to the Cancer Cell Surface

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Cognizance of Molecular Methods for the Generation of Mutagenic Phage Display Antibody Libraries for Affinity Maturation

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Generation of recombinant antibodies and means for increasing their affinity

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Development of a Novel, Fully Human, Anti-PCSK9 Antibody with Potent Hypolipidemic Activity by Utilizing Phage Display-Based Strategy

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Cleavage-intermediate Lassa virus trimer elicits neutralizing responses, identifies neutralizing nanobodies, and reveals an apex-situated site-of-vulnerability

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Targeting RyR2 with a phosphorylation site–specific nanobody reverses dysfunction of failing cardiomyocytes in rats

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Cross-reactive antibodies targeting surface-exposed non-structural protein 1 (NS1) of dengue virus-infected cells recognize epitopes on the spaghetti loop of the β-ladder domain

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A fully human connective tissue growth factor blocking monoclonal antibody ameliorates experimental rheumatoid arthritis through inhibiting angiogenesis

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A General Sequence Processing and Analysis Program for Protein Engineering

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Generative Diffusion Models for Antibody Design, Docking, and OptimizationPreprint

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Immunochemical engineering of cell surfaces to generate virus resistance

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A novel lentiviral scFv display library for rapid optimization and selection of high affinity antibodies

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A review of in vitro stochastic and non-stochastic affinity maturation strategies for phage display derived monoclonal antibodies

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Germline Genetics in Cancer: The New Frontier

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High Affinity Maturated Human Antibodies from Naïve and Synthetic Antibody Repertoires

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Evolution of Bioaffinity Reagents by Phage Display

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Improving antibody affinity by mimicking somatic hypermutation in vitro

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In Vitro Antibody Evolution Targeting Germline Hot Spots to Increase Activity of an Anti-CD22 Immunotoxin

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Affinity maturation of a VHH by mutational hotspot randomization

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In vitro affinity maturation of a human ScFv against TNF-α by mutating the hot spots in somatic hypermutation

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Affinity Maturation by Random Mutagenesis and Phage Display

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