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Cited by 1,773

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Protein Structure Modeling with MODELLER

Eswar, Narayanan, Eramian, David, Webb, Ben, Shen, Min-Yi, Sali, Andrej·2008·Methods in Molecular Biology

Abstract

Genome sequencing projects have resulted in a rapid increase in the number of known protein sequences. In contrast, only about one-hundredth of these sequences have been characterized using experimental structure determination methods. Computational protein structure modeling techniques have the potential to bridge this sequence-structure gap. This chapter presents an example that illustrates the use of MODELLER to construct a comparative model for a protein with unknown structure. Automation of similar protocols (correction of protcols) has resulted in models of useful accuracy for domains in more than half of all known protein sequences.

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Metadata

Authors
Eswar, N., Eramian, D., Webb, B., Shen, M.-Y., & Sali, A.
Venue
Methods in Molecular Biology
Publisher
Humana Press
Published
2008
Volume
426
Pages
145-159
ISSN
  • 1064-3745 (ISSN-L)
  • 1940-6029
OpenAlex
W95014119
Cited by
1,773
References
6
FWCI
79.71
Type
book chapter
Language
en
Open access
closed

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CoChat. (2026). Citation check: Protein Structure Modeling with MODELLER. https://app.cochat.ai/papers/10.1007/978-1-60327-058-8_8
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Eswar, N., Eramian, D., Webb, B., Shen, M.-Y., & Sali, A. (2008). Protein Structure Modeling with MODELLER. Methods in Molecular Biology. https://doi.org/10.1007/978-1-60327-058-8_8

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.