Cited by 2,458Protein Structure and DynamicsEnzyme Structure and FunctionRNA and protein synthesis mechanisms

The relation between the divergence of sequence and structure in proteins.

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Chothia, C., Lesk, A.M.·1986·The EMBO Journal

Abstract

Homologous proteins have regions which retain the same general fold and regions where the folds differ. For pairs of distantly related proteins (residue identity approximately 20%), the regions with the same fold may comprise less than half of each molecule. The regions with the same general fold differ in structure by amounts that increase as the amino acid sequences diverge. The root mean square deviation in the positions of the main chain atoms, delta, is related to the fraction of mutated residues, H, by the expression: delta(A) = 0.40 e1.87H.

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Crossref · 10.1002/j.1460-2075.1986.tb04288.x

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Authors
Chothia, C., & Lesk, A. M.
Venue
The EMBO Journal
Published
1986-04-01
Volume
5
Issue
4
Pages
823-826
ISSN
  • 0261-4189 (ISSN-L)
  • 1460-2075
OpenAlex
W1508885706
Cited by
2,458
References
28
Citations by year
2026: 61 · 2025: 56 · 2024: 44 · 2023: 66 · 2022: 62 · 2021: 52 · 2020: 56 · 2019: 59 · 2018: 74 · 2017: 67 · 2016: 64 · 2015: 67 · 2014: 67 · 2013: 100 · 2012: 96
FWCI
8.63
Type
journal article
Language
en
Open access
Locations
  • The EMBO Journal (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of General Medical Sciences (GM25435)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Structure and Dynamics
  • Physical Sciences › Materials Science › Materials Chemistry › Enzyme Structure and Function
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
Keywords
sequence-structure relationship, protein folding, homologous proteins, sequence divergence, structural divergence, RMSD, main-chain conformation, distant homologs
MeSH terms
Amino Acid Sequence, Animals, Humans, Mutation, Protein Conformation, Proteins, Structure-Activity Relationship

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